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预防医学  2018, Vol. 30 Issue (11): 1100-1105,1111    DOI: 10.19485/j.cnki.issn2096-5087.2018.11.006
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大气PM2.5对呼吸系统疾病死亡率影响的Meta分析
顾雯雯, 杨洛贤, 程庆林
杭州市疾病预防控制中心,浙江 杭州 310021
Meta-analysis of the effect of PM2.5 on mortality of respiratory diseases
GU Wen-wen, YANG Luo-xian, CHENG Qing-lin
Hangzhou Center for Disease Control and Prevention,Hangzhou,Zhejiang 310021,China
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摘要 目的 探讨大气PM2.5短期效应(<7 d)对呼吸系统疾病死亡率的影响。方法 以颗粒物、 PM2.5、大气污染物、呼吸系统和死亡为关键词检索中国知网、万方数据知识服务平台、维普中文科技期刊数据库、PubMed和Web of Science,纳入研究中国PM2.5与人群呼吸系统疾病死亡率关系的文献,以PM2.5每增加10 μg/m3人群呼吸系统疾病死亡率增加的百分比(ER值)为效应指标,采用Stata 14.0软件进行Meta分析,并按照滞后类型和研究方法进行亚组分析。结果 共检索到相关文献1 564篇,最终纳入符合条件的文献17篇,其中中文文献7篇,英文文献10篇。采用随机效应模型对纳入文献进行合并,显示PM2.5每增加10 μg/m3,人群呼吸系统疾病死亡率增加0.48%(95%CI:0.35%~ 0.62%)。亚组分析显示,PM2.5每增加10 μg/m3的单天滞后效应使人群呼吸系统疾病死亡率增加0.53%(95%CI:0.31%~ 0.74%),I2值为65%;累积滞后效应为0.35%(95%CI:0.25%~0.45%),I2值为44%。时间序列研究中,PM2.5每增加10 μg/m3人群呼吸系统疾病死亡率增加0.51%(95%CI:0.34%~0.67%),I2值为61%;病例交叉研究为0.32%(95%CI:0.15%~0.49%),I2值为46%。敏感性分析未见明显差异。Egger检验P=0.005,具有发表偏倚。结论 PM2.5升高可能会增加人群呼吸系统疾病死亡率。
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顾雯雯
杨洛贤
程庆林
关键词 PM2.5呼吸系统疾病死亡率Meta分析    
AbstractObjective To explore the relationship between short-term(less than seven days)exposure to PM2.5 and daily respiratory death.Methods We searched for China National Knowledge Infrastructure,Wanfang Database,VIP Database,PubMed and Web of Science by using particulate matter,PM2.5,atmospheric pollutants,respiratory system and death as the key words. The literatures on the relationship between PM2.5 and mortality from respiratory diseases in China were included. The increasing percentage of mortality from respiratory disease while increasing by 10 μg/m3 of PM2.5 was used as the effect indicator(ER). Stata 14.0 software were used to conduct meta-analysis,and subgroup analysis was performed according to the type and study methods.Results A total of 1 564 related articles were retrieved,and 17 articles that met the requirements were finally included,including 7 Chinese articles and 10 English articles. The inclusion of the literature using a random effects model showed that for every 10 μg/m3 increase in PM2.5,the mortality rate of respiratory disease in the population increased by 0.48%(95%CI: 0.35%-0.62%). In the subgroup analysis,the single-day lag effect of PM2.5 increased by 10 μg/m3 increased the mortality of respiratory diseases in the population by 0.53%(95%CI: 0.31%- 0.74%),and the I2 value was 65%; the cumulative lag effect was 0.35%(95%CI: 0.25%-0.45%)with an I2 value of 44%. In the time series study,respiratory disease mortality increased by 0.51%(95%CI: 0.34%-0.67%)and I2 value was 61% for every 10 μg/m3 increase in PM2.5,and the case crossover study was 0.32%(95%CI: 0.15%-0.49%),and the I2 value was 46%. There were no significant differences in sensitivity analysis. Egger’s test showed publication bias was existing(P=0.005).Conclusion Elevated level of PM2.5 may increase mortality in respiratory diseases in the population.
Key wordsPM2.5    Respiratory disease    Mortality    Meta-analysis
收稿日期: 2018-04-20      修回日期: 2018-08-06      出版日期: 2018-11-06
中图分类号:  R122.7  
基金资助:杭州市科技计划引导项目(20163501Y36)
通信作者: 杨洛贤,E-mail:178721714@qq.com   
作者简介: 顾雯雯,硕士,主治医师,主要从事疾病预防与控制工作
引用本文:   
顾雯雯, 杨洛贤, 程庆林. 大气PM2.5对呼吸系统疾病死亡率影响的Meta分析[J]. 预防医学, 2018, 30(11): 1100-1105,1111.
GU Wen-wen, YANG Luo-xian, CHENG Qing-lin. Meta-analysis of the effect of PM2.5 on mortality of respiratory diseases. Preventive Medicine, 2018, 30(11): 1100-1105,1111.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2018.11.006      或      http://www.zjyfyxzz.com/CN/Y2018/V30/I11/1100
[1] 世界卫生组织. 环境(室外)空气质量和健康[S/OL].(2017- 12-19)[2018-04-20]. http://www.who.int/mediacentre/ factsheets/ fs313/zh/.
[2] GBD 2016 risk factors collaborators. Global,regional,and national comparative risk assessment of 84 behavioural,environmental and occupational,and metabolic risks or clusters of risks,1990-2016: a systematic analysis for the Global Burden of Disease Study 2016[J]. Lancet,2017,390: 1345-422.
[3] 郭杰,肖纯凌. PM 2.5 对人群健康影响的流行病学研究进展[J]. 环境卫生学杂志,2017,7(2):164-169.
[4] 张世鑫,伍立志,陈苘,等. 大气细颗粒物及其水提物对人支气管上皮细胞的氧化损伤效应[J]. 浙江预防医学,2016,28(4):332-335,339.
[5] POPE C A,DOCKERY D W. Health effects of fine particulate air pollution: lines that connect[J]. J Air Waste Manag Assoc,2006,56(10):709-742.
[6] 赵凤敏,吴一峰,吴峰. 大气污染物浓度与上呼吸道疾病门诊就诊的关联性研究[J]. 浙江预防医学,2016,28(2):165- 167,170.
[7] AARON V D,MARTIN R V,MICHAEL B,et al. Global estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth:development and application[J]. Environl Health Perspect,2010,118(6):847-855.
[8] ZHENG X Y,DING H,JIANG L N,et al. Association between air pollutants and asthma emergency room visits and hospital admission in time series studies:a systematic review and meta-analysis[J].PLoS ONE,2015,10(9):e0138146.
[9] CHANG X H,ZHOU L J,TANG M,et al. Association of fine particles with respiratory disease mortality:a meta-analysis[J]. Arch Environ Occup Health,2015,70(2):98-101.
[10] MUSTAFIC H,JABRE P,CAUSSIN C,et al. Main air pollutants and myocardial infarction:a systematic review and meta-analysis[J]. JAMA,2012,307(7):713-721.
[11] REN M Y,FANG X,LI M,et al. Concentration-response relationship between PM 2.5 and daily respiratory deaths in China:a systematic review and meta regression analysis of time-series studies[J]. Bio Res Int,2017,2017(140):1-15.
[12] ZHANG F Y,LIU X J,ZHOU L,et al. Spatiotemporal patterns of particulate matter(PM)and associations between PM and mortality in Shenzhen,China[J]. BMC Public Health,2016,16(1):1-11.
[13] ATKINSON R W,KANG S,ANDERSON H R,et al. Epidemiological time series studies of PM 2.5 and daily mortality and hospital admissions:a systematic review and meta-analysis[J]. Thorax,2014,69:660-665.
[14] 冯文如,刘世强,黄勇,等. 广州市PM 2.5 浓度与人群每日死亡风险的空间分布特征[J]. 环境卫生学杂志,2015,5(6):512-519.
[15] 齐爱,牛照地,吴惠忠,等. 银川市大气颗粒污染物对人群呼吸系统疾病死亡影响的病例交叉研究[J]. 现代预防医学,2017,44(18):3300-3304.
[16] 郭永超,李洁,谢俊卿,等. 2013年丰台区PM 2.5 与居民呼吸系统疾病死亡的关系研究[J]. 环境卫生学杂志,2016,6(1):46-50.
[17] 葛锡泳,王临池,陆艳. 苏州市大气颗粒物与居民呼吸系统疾病死亡的时间序列分析[J]. 环境与健康杂志,2015,32(6):494-497.
[18] 张旭辉,周伟杰,张熙. 无锡市大气污染物对人群日死亡数和日就诊数的时间序列分析研究[J]. 环境卫生学杂志,2016,12(6):407-411.
[19] 曾婕,刘睿聪,陈剑宇,等. 成都市PM 2.5 水平与人群熟悉系统疾病死亡的时间序列研究[J]. 江苏预防医学,2017,28(2):144-146,168.
[20] 秦萌,陈英,李敬芝,等. 上海市奉贤区主要大气污染物对人群呼吸系统急性健康效应的影响[J]. 东南大学学报(医学版),2017,36(2):197-202.
[21] YANG C X,PENG X,HUANG W,et al. A time-stratified case-crossover study of fine particulate matter air pollution and mortality in Guangzhou,China[J]. Int Arch Occup Environ Health,2012,85(5):579-585.
[22] CHEN R J,YIN P,MENG X,et al. Fine particulate air pollution and daily mortality-a nationwide analysis in 272 Chinese cities[J]. Am J Respir Cirt Care Med,2017,196(1):73-81.
[23] MA Y J,CHEN R,PAN G,et al. Fine particulate air pollution and daily mortality in Shenyang,China[J]. Sci Total Environ,2011, 409(13):2473-2477.
[24] LI P,XIN J Y,WANG Y S,et al. The acute effects of fine particles on respiratory mortality and morbidity in Beijing,2004-2009[J]. Environ Sci Pollut Res,2013,20(9):6433- 6444.
[25] LIN H L,MA W,QIU H,et al. Is standard deviation of daily PM 2.5 concentration associated with respiratory mortality?[J]. Environl Pollut,2016,216:208-214.
[26] LI P,XIN J Y,WANG Y S,et al. Time-series analysis of mortality effects from airborne particulate matter size fractions in Beijing[J]. Atmosph Environ,2013,81(2):253-262.
[27] LI T T,YAN M L,SUN Q H,et al. Mortality risks from a spectrum of causes associated with wide-ranging exposure to fine particulate matter:a case-crossover study in Beijing,China[J]. Environ Int,2018,111:52-59.
[28] LIN H L,LIU T,XIAO J P,et al. Quantifying short-term and long-term health benefits ofattaining ambient fine particulate pollution standards in Guangzhou,China[J]. Environ Int,2016,137:38-44.
[29] LI Y,MA Z Q,ZHENG C J,et al. Ambient temperature enhanced acute cardiovascular-respiratory mortality effects of PM 2.5 in Beijing,China[J]. Int J Biometeorol,2015,59(12):1761-1770.
[30] HUANG W,CAO J J,TAO Y B,et al. Seasonal variation of chemical species associated with short-term mortality effects of PM 2.5 in Xi'an,a central city in China [J]. Am J Epidemiol,2012, 175(6):556-566.
[31] SHANG Y,SUN Z,CAO J J,et al. Systematic review of Chinese studies of short-term exposure to air pollution and daily mortality[J]. Environ Int,2013,54(4):100-111.
[32] 刘昌景,黄飞,杨志洲,等. 我国空气污染物与人群呼吸系统疾病死亡急性效应的meta分析[J]. 中华流行病学杂志,2015, 36(8):889-895.
[33] 田璐,金曼,佟俊旺. 应用Meta分析研究我国PM 2.5 污染与居民每日死亡的关系[J]. 环境与职业医学,2015,32(11):1013-1018.
[34] BRUNEKREEF B,HOLGATE S T. Air pollution and health[J]. Lancet,2002,360(9341):1233-1242.
[35] ACHILLEOS S,KIOUMOURTZOGLOU M A,WU C D,et al. Acute effects of fine particulate matter constituents on mortality:a systematic review and meta-regression analysis[J]. Environ Int,2017,10(109):89-100.
[36] CARRACEDO-MARTINEZ E,TARACIDO M,TOBIAS A,et al. Case-crossover analysis of air pollution health effects:a systematic review of methodology and application[J]. Environ Health Per,2010,118(8):1173-1182.
[37] DOMINICI F,MCDERMOTT A,ZEGER S L,et al. On the use of generalized additive models 340 in time-series studies of air pollution and health[J]. Am J Epidemiol,2002,156:193-203.
[38] 张政,詹思延. 病例交叉设计[J]. 中华流行病学杂志,2001, 22(4):304-306.
[39] GUO Y M,BARNETT A G,ZHANG Y S,et al. The short -term effect of air pollution on cardiovascular mortality in Tianjin,China:comparison of time series and case-crossover analyses[J]. Sci Total Environ,2010,409:300-306.
[40] 陈月红,杜亮,耿兴远,等. 无对照二分类数据的Meta分析在RevMan软件中的实现[J]. 中国循证医学杂志,2014,14(7):889-896.
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