Abstract：Objective To analyze the incidence and death of malignant tumors in Haishu District during 2011 to 2016，and to provide reference for the formulation and adjustment of prevention and control strategies and measures. Methods From the chronic disease monitoring system of Zhejiang Province，the data of the death report of residents in Haishu district and the monitoring report of chronic disease were obtained for 2011 to 2016 years. The mortality of malignant tumor，incidence of malignant tumor，and survival rate of malignant tumor in residents were statistically analyzed. Results The mortality of malignant tumor in Haishu district from 2011 to 2016 was 182.00/100，000 to 215.43/100，000，however the malignant tumor mortality rate of males were significantly higher than females （P<0.01）. Malignant tumor was the first death cause of residents in Haishu district，and the death rate of malignant tumor accounted for over 30% of all deaths. The average life expectancy loss of residents was 4.36 years due to cancer. The incidence of malignant tumor increased with age （P<0.01），and males were significantly higher than females in 2011 and 2012（P<0.05），however there was no significantly difference between male and female after 2012（P>0.05）. The top five deaths of malignant tumors were lung cancer，gastric cancer，colorectal cancer，liver cancer and pancreatic cancer，and the incidence of these five malignant tumors from high to low was lung cancer，colorectal cancer，gastric cancer，liver cancer and pancreatic cancer. The five year survival rate from high to low was colorectal cancer，gastric cancer，lung cancer，liver cancer and pancreatic cancer，respectively. Conclusion Malignant tumor has become the main cause of threat to the life and health of residents in Haishu district. It is suggested to strengthen the screening of early diagnosis and treatment of cancer.