Varicella vaccination coverage and vaccine effectiveness among children born in Changsha City from 2012 to 2021
LUO Meiling, ZHANG Ying, LI Li
Changsha Center for Disease Control and Prevention (Changsha Municipal Bureau of Comprehensive Health Supervision and Law Enforcement), Changsha, Hunan 410004, China
Abstract：Objective To analyze the varicella attenuated live vaccine (VarV) vaccination rate and the vaccine effectiveness (VE) among children born in Changsha City from 2012 to 2021, so as to provide evidence for improving varicella prevention and control strategies and enhancing population immunity. Methods Data on children born in Changsha City from 2012 to 2021 were collected through the Hunan Provincial Immunization Program Information Management System. Data on laboratory-confirmed and clinically diagnosed varicella cases in Changsha City from 2012 to 2025 were collected through the Surveillance System of China Information System for Disease Control and Prevention. Individual records were matched by ID number, name and date of birth. A retrospective cohort study was conducted, with date of birth as the starting point of observation and December 31, 2025 or the date of varicella onset as the end point of observation. VarV vaccination coverage was analyzed, and the incidence density of varicella was calculated among children in different birth years and receiving different doses of VarV. A multivariable Cox proportional hazards regression model was used to calculate the hazard ratio, and to estimate the vaccine effectiveness (VE) with its 95%CI. Results A total of 1 433 051 children were enrolled, including 755 427 boys and 677 624 girls, with a boy-to-girl ratio of 1.11∶1. A total of 1 245 435 children received VarV, with a vaccination coverage of 86.91%. Among them, 283 944 children received one dose of VarV, with a vaccination coverage of 19.81%; 961 491 children received two doses of VarV, with a vaccination coverage of 67.09%. Children born in 2019 had a relatively high VarV vaccination coverage of 90.16%, children born in 2021 had a relatively high one-dose VarV vaccination rate of 43.83%, children born in 2018 had a relatively high two-dose VarV vaccination rate of 77.12%, respectively. As of December 31, 2025, 16 897 varicella cases were reported, with an overall incidence density of 134.37/105 person-years. Children born in 2012 had a relatively high incidence density of varicella of 173.76/105 person-years, while children born in 2020 and 2021 had relatively low incidence densities of 97.07/105 person-years and 99.80/105 person-years, respectively. Compared with no VarV vaccination, the VE of one-dose and two-dose VarV were 65.53% (95%CI: 63.78%-66.19%) and 95.83% (95%CI: 95.63%-96.02%), respectively. Conclusions The VarV vaccination coverage among children in Changsha City was at a moderate level. The incidence density of varicella decreased with later birth year. VarV vaccination can effectively prevent varicella in children, and the VE of two-dose VarV was better than one-dose VarV.
罗美玲, 张英, 李栎. 长沙市2012—2021年出生儿童水痘疫苗接种率和保护效果分析[J]. 预防医学, 2026, 38(10): 992-995,1001.
LUO Meiling, ZHANG Ying, LI Li. Varicella vaccination coverage and vaccine effectiveness among children born in Changsha City from 2012 to 2021. Preventive Medicine, 2026, 38(10): 992-995,1001.
