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| Pregnancy outcomes among women with high and low risk in first and second trimester prenatal screening analysis |
| CHEN Yi-ming, ZHANG Wen, LU Sha, ZHANG Yan-zhen, LIAN Jie-jing, ZHANG Li-dan, WANG Min,WANG Hao,MEI Jin ,HU Wen-sheng
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| Department of Prenatal Diagnosis Centre,Hangzhou Women's Hospital,Hangzhou,Zhejiang 310008,China |
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Abstract Objective To analyze adverse pregnancy outcomes among women with high risk and low risk during prenatal screening. Methods Clinical data of 180 006 pregnancies in 5 prenatal screening center in Hangzhou were collected. We compared the adverse pregnancy outcomes of high and low risk pregnancies. Results Among 180 006 pregnancies（age<35 years old）,there were 10 296 high-risk cases and 169 710 low-risk cases,with 168 654 cases followed. There were 9 406 high-risk cases of Down's syndrome（DS）（5.23%）,273 high-risk cases of Edwards' syndrome（ES）（0.15%）and 617 high-risk cases of open neural tube defect（ONTD）（0.34%）. The detection rate of pregnancy outcome of premature birth,spontaneous abortion,termination of pregnancy,stillbirth in the high risk was 5.46%,0.80%,1.80%,0.37%,respectively,and that rate in low risk results was 3.50%,0.21%,0.38%,0.18%,respectively. Adverse pregnancy outcomes in high-risk group were significantly higher than that in low-risk group（all P<0.001）. The actual incidence rate of DS,ES or ONTD in high-risk group （4.56‰,1.65‰,0.97‰,respectively）were significantly higher than that in low-risk group（0.12‰,0.04‰,0.09‰,respectively,all P<0.001）. The detection rates of prenatal screening were 70.15%,68.00% and 38.46%,and false positive rates were 5.23%,0.14% and 0.34%。Conclusion High risk of serum prenatal screening analysis is associated with adverse pregnancy outcomes. The number of pregnancies experienced invasive prenatal diagnosis can be reduced by routine serum prenatal screening. That is an Effective method to reduce the birth defects.
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Received: 25 September 2017
Revised: 16 December 2017
Published: 06 March 2018
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