|
|
|
| Astudyontheeffectofwholecranberrypowderonimmunefunction ofICRmiceinvivo |
| XU Cai-ju, LU Wei, SONG Yan-hua, CAI De-lei, XIA Yong, ZHENG Yun-yan
|
| TheCenterforDiseaseControlandPreventionofZhejiangProvince,Hangzhou,Zhejiang310051,China |
|
|
|
|
Abstract ObjectiveTo evaluate the effects of whole cranberry powder (Pacran�� powder) on immune functions of ICR mice invivo.MethodsFemale ICR mice (18-22 g) were randomly divided into control group and low, medium and high dose groups of whole cranberry powder ( 83,166, and 332 mg/kgbw). Whole cranberry powder was treated with by gavage for 30 days continuously. Control mice were treated with distilled water only. Their immune functions were analyzed, including serum hemolysin analysis, antibody-producing cells (APCs), conA-induced splenic lymphocyte transformation, SRBC-induced delayed type hypersensitivity, natural killer cell activity assay, peritoneal macrophages phagocytosed chicken red blood cells (CRBC), carbon clearance test and thymus or spleen /body weight ratio.ResultsAs compared with the controls, whole cranberry powder treatment increased the number of plague forming cells (PFCs) at 83 mg/kgbw group(P<0.05). There were no statistical difference in the total production of antibodies, the activity of conA-induced splenic lymphocyte transformation, the left-hind voix pedis thickness, NK cytoactivity, the phagocytosis index and ratio of peritoneal macrophages, the carbon clearance ability between the groups treated with different concentrations of whole cranberry powder and the control group (P>0.05).ConclusionWhole cranberry powder can enhance mouse the number of plague forming cells (PFCs).
|
|
Received: 30 November 2015
Revised: 06 January 2016
Published: 05 January 2018
|
|
|
|
|
|
[1] UPTON R.(ed). Cranberry Fruit: Vaccinium macrocarpon Aiton: Standards of Analysis. Quality Control, and Therapeutics. American Herbal Pharmacopoeia TM and Therapeutic Compendium. American Herbal Pharmacopoeia TM , Santa Cruz (CA). 2002.
[2] PALIKOVA I, VOSTALOVA J, ZDARILOVA A, et al. Long-term effects of three commercial cranberry products on the antioxidative status in rats: a pilot study [J].J Agric Food Chem,2010, 58(3):1672-1678.
[3] VOSTALOVA J, VIDLAR A, SIMANEK V, et al. Are high
proanthocyanidins key to cranberry efficacy in the prevention of recurrent urinary tract infection?[J].Phytother Res, 2015, 29(10):1559-1567.
[4] LI Z P, SEERAM N P, CARPENTER C L, et al. Cranberry does not affect prothrombin time in male subjects on warfarin[J]. J Am Diet Assoc,2006,106(12):2057-2061.
[5] LILJA J J, BACKMAN J T,NEUVONEN P J. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam-probes of CYP2c9, VYP1A2, and CYP3A4[J].Clin Pharmacol Ther,2007,81(6): 833-839.
[6] XU C J, DING G Q, FU J Y, et al. Immunoregulatory of ethyl-acetate fraction of extracts from Tetrastigma hemsleyanum Diels et. Gilg on immune function of ICR mice[J]. Biomed Environ Sci, 2008,21(4):325-331.
[7] JEPSON R G, CRAIG J C. A systematic review of the evidence for cranberries and blueberries in UTI prevention[J]. Mol Nutr Food Res, 2007, 51(6):738-745.
[8] JEPSON R G, CRAIG J C. Cranberries for preventing urinary tract infections[J]. Cochrane Database Syst Rev, 2008,1(1):1321.
[9] MCMURDO M E, BISSETT L Y, PRICE R J, et al. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A doubleblind,placebo-controlled trial[J]. Age Ageing,2005, 34(3):256-261.
[10] WING D A,RUMNEY P S.Comparison of urinary cytokines after ingestion of cranberry juice cocktail in pregnant subjects: a pilot study[J]. Am J Perinat. 2010,27(2): 137-142.
[11] YAN X J, MURPHY B T, HAMMOND G B, et al. Antioxidant activities and antitumor screening of extracts from cranberry fruit ( Vacciniummacrocarpon )[J]. J Agric Food Chem, 2002, 50(21):5844-5849.
[12] BAGCHI D, SEN C K, BAGCHI M, et al. Anti-angiogenic,
antioxidant,and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula[J]. Biochemistry (Mosc), 2004, 69(1):75-80.
[13] FERGUSON P J, KUROWSKA E, FREEMAN D J, et al. A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines[J]. J Nutr, 2004, 134(6):1529-1535.
[14] CHU Y F, LIU R H. Cranberries inhibit LDL oxidation and induce LDL receptor expression in hepatocytes[J]. Life Sci, 2005, 77(15):1892-1901.
[15] KIM M J, OHN J, KIM J H, et al. Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet.Nutrition Research and Practice[J]. Nutr Res Pract, 2011,5(5):404-411.
[16] LAVIGNE J P, VITRAC X, BERNARD L, et al. Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections[J]. BMC Res Notes, 2011(4):522.
[17] DE LLANO D G, ESTEBAN-FERNÁNDEZ A, SÁNCHEZ-PATÁN F, et al. Anti-adhesive activity of cranberry phenolic compounds and their microbialderived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures[J]. Int J Mol Sci, 2015,16(6):12119-12130.
[18] MAHER M A, MATACZYNSKI H, STEFANIAK H M, et al. Cranberry juice induces nitric oxide-dependent vasodilation in vitro and its infusion transiently reduces blood pressure in anesthetized rats[J]. J Med Food, 2000, 3(3):141-147.
[19] RAZ R, CHAZAN B, DAN M. Cranberry juice and urinary tract infection[J]. Clin Infect Dis, 2004, 38(10):1413-1419.
[20] LEE Y L, NAJM W I, OWENS J, et al. Anti-microbial activity of urine after ingestion of cranberry: a pilot study[J]. Evid Based Complement Alternat Med, 2010,7(2):227-232.
[21] HOWELL A B, REED J D, KRUEGER C G,et al. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity[J]. Phytochemistry, 2005, 66(18): 2281-2291.
[22] HOWELL A B, BOTTO H, COMBESCURE C, et al. Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study[J]. BMC Infect Dis, 2010(10):94.
[23] VALENTOVÁ K, STEJSKAL D, BEDNÁ R ˇ P, et al. Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial[J]. J Agric Food Chem, 2007,55(8):3217-3224. |
| [1] |
. [J]. Preventive Medicine, 2021, 33(12): 1290-1294. |
|
|
|
|
