|
|
|
| A meta-analysis on the association of the codon 72 polymorphism in p53 gene with the cervical cancer in Chinese population |
| YU Fang-ming,YE Teng,SU Yang-na,MAO Guang-yun,SHI Xiao-ke,ZHANG Ben-long
|
| Chouzhou Hospital of Yiwu City,Yiwu,Zhejiang,322000,China |
|
|
|
|
Abstract Objective To evaluate the association of cervical cancer and the G/C single nucleotide polymorphism at codon 72 in p53 gene exon-4 in Chinese population.Methods Literatures were searched in CNKI, VIP, CBM, PubMed, EMBase, the Cochrane Library (Issue 1, 2015), WanFang Data Database (1980—2015) with computer.Results Thirteen studies involving 1 780 cervical cancer patients and 1 517 healthy volunteers were included. According to the situation of the HPV infection in research object, thirteen studies were divided into two subgroups. The results of meta-analyses in the subgroup of non-HPV infection showed that the Chinese women having the genotype G/G presented no increased relative risk compared to that with the genotype C/C(OR=0.980, 95%CI: 0.558-1.723).The allele G showed no increased relative risk compared to the allele C (OR=1.070, 95%CI: 0.789-1.449) The results of meta-analyses in the subgroup of HPV infection showed that the Chinese women having the genotype G/G presented no increased relative risk compared to that with the genotype C/C(OR=0.891, 95%CI: 0.213-3.722).The allele G showed no increased relative risk compared to the allele C (OR=0.981, 95%CI: 0.493-1.951).Conclusion This meta-analysis demonstrates that G/C single nucleotide polymorphism at codon 72 in p53 gene exon-4 were not associated with cervical cancer in Chinese women.
|
|
Published: 26 December 2017
|
|
|
|
|
|
[1]陈争春, 黄勇进. 子宫颈癌及宫颈上皮内瘤变流行病学调查[J]. 中国现代医药杂志, 2012, 14(6):42-44.
[2]朱新勇, 张同全, 王福春, 等. p53、bcl-2和nm23基因在胃癌组织中的表达及其临床意义[J]. 中国普外基础与临床杂志, 2003, 10(6):589-592.
[3]YAO N, ZHENG H. Correlation between p53 codon72polymorphism and cervical cancer[J]. Acta Academiae Medicinae Zunyi, 2008, 31(1):1-5.
[4]EL KHAIR M M, ENNAJI M M, ELKEBBAJ R, et al. p53 codon72 polymorphism and risk of cervical carcinoma in Moroccan women[J]. Med Oncol, 2010, 27(3): 861-866.
[5]LITTLE J, HIGGINS J PT, IOANNIDIS J PA, et al. Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement[J]. Eur J Epidemiol, 2009, 24(1): 37-55.
[6]王静, 莫传伟, 陈群, 等. 应用Stata软件的Meta分析完成医学科研定量评价[J]. 中华中医药学刊, 2008, 26(5):947-949.
[7]郄明蓉,张燕华,吴俊梅. p53 Codon 72多态性与宫颈癌关系的研究[J]. 华西医科大学学报,2002,33(2):274-275.
[8]王晓凌, 潘晓琳, 高志斌,等. p53 Codon72 多态性与新疆维吾尔族、汉族宫颈癌发生的相关性研究[J]. 石河子大学学报(自然科学版),2004,22(4):340-344.
[9]侯敏敏, 郄明蓉, 曹泽毅, 等. p53基因第72位密码子多态性与宫颈癌及HPV-16、18 E6之间关系的研究[J]. 四川大学学报(医学版), 2006, 37(3): 404-407.
[10]杨安强, 郑兴征, 陶林, 等. p53Arg72Pro、p21Ser31Arg多态性与新疆维吾尔族宫颈癌的相关性[J]. 石河子大学学报(自然科学版), 2008, 26(1):6-11.
[11]姚宁, 郑洪, 路健. p53 基因Codon72 多态性与宫颈癌关系的研究[J]. 遵义医学院学报, 2008, 31(1):3-5.
[12]陈长春, 丁晓华, 蔡红兵. 湖北地区汉族人群p53基因第72位密码子多态性与宫颈鳞癌相关性[J]. 肿瘤学杂志, 2009, 15(11):961-964.
[13]周秋媛, 潘晓琳, 李新敏, 等. p53Arg72Pro多态性与HPV相关宫颈癌发生机制[J]. 中国肿瘤, 2009, 18(2):136-139.
[14]YE F, ZHANG J, CHENG Q, et al. p53 Codon 72 polymorphism is associated with occurrence of cervical carcinoma in the Chinese population[J].Cancer Lett,2010,287(1):117-121.
[15]眭鸿颖, 周萍, 江宁. 湖南地区汉族人群p53基因第72位密码子多态性与宫颈鳞癌的相关性[J]. 现代生物医学进展, 2011, 11(11):2083-2086.
[16]杨敏, 徐景杰. p53基因第72密码子基因多态性和蒙古族妇女宫颈癌的相关性分析[J]. 医学综述, 2011, 17(21):3352-3354.
[17]陈长春, 丁晓华, 蔡红兵. p53基因第72位密码子基因多态性与HPV16相关宫颈癌[J]. 中国当代医药, 2012, 19(8):9-10.
[18]严志凌, 周红林, 张红平, 等. 宿主p53基因多态性与HPV16感染、宫颈癌发生发展的相关性[J]. 昆明医科大学学报, 2014, 35(5):37-40.
[19]YUAN F, SUN R, CHEN P, et al. Combined analysis of pri-miR-34b/c rs4938723 and Tp53 Arg72Pro with cervical cancer risk[J].Tumor Biol,2016,37(5):6267-6273.
[20]李文娟, 潘庆杰, 李美玉. p53 基因及其功能研究进展[J]. 生物技术通讯, 2014, 25(2): 282-285.
[21]KAZEMI M,SALEHI Z, CHAKOSARI R J. TP53 codon 72 polymorphism and breast cancer in northern Iran[J].Oncol Res, 2009, 18(1):25-30.
[22]王剑蓉, 赖仁胜. p53 codon 72 多态与肿瘤的相关性[J].江苏医药, 2006, 32(12): 1138-1139.
[23]樊晓妹, 单保恩, 李魁秀. 基因多态性与宫颈癌易感性研究进展[J]. 中华肿瘤防治杂志, 2014, 21(14):1125-1128.
[24]STOREY A, THOMAS M, KALITA A, et al. Role of a p53 polymorphism in the development of human papillomavirus-associated cancer[J]. Nature, 1998, 393(6682): 229-234.
[25]CENCI M, FRENCH D, PISANI T, et al. p53 polymorphism at codon 72 is not a risk factor for cervical carcinogenesis in central Italy[J]. Anticancer Res, 2003, 23(2B): 1385-1387.
[26]LANHAM S, CAMPBELL I, WATT P, et al. p53 polymorphism and risk of cervical cancer[J]. Lancet, 1998, 352(9140): 1631.
[27]NIWA Y, HAMAJIMA N, ATSUTA Y, et al. Genetic
polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical cancer in Japanese[J]. Cancer Lett, 2004, 205(1): 55-60.
[28]UEDA M, TOJI E, NUNOBIKI O, et al. Germline polymorphisms of glu tathione-S-transferase GSTM1, GSTT1 and p53 codon 72 in cervical carcinogenesis[J]. Hum Cell, 2010, 23(4): 119-125.
[29]SETTHEETHAM-ISHIDA W, KANJANAVIROJKUL N,
KULARBKAEW C, et al. Human papillomavirus genotypes and the p53 codon 72 polymorphism in cervical cancer of Northeastern Thailand[J]. Microbiol Immunol, 2005, 49(5): 417-421.
[30]NAGPAL J K, SAHNI S, DAS B R. p53 codon 72 polymorphism and susceptibility to development of human papilloma virus-associated cervical cancer in Indian women[J]. Eur J Clin Invest, 2002, 2(12): 943-948.
[31]ROH J W, KIM B K, LEE C H, et al. p53 codon 72 and p21 codon 31 polymorphisms and susceptibility to cervical adenocarcinoma in Korean women[J]. Oncol Res, 2010, 18(9): 453-459.
[32]ZHENG X Z, YANG A Q, PAN X L, et al.Ethnicity determines association of p53Arg72Pro alleles with cervical cancer in China[J]. Eur J Cancer Prev, 2008, 17(5):460-466.
[33]ZHOU X, GU Y, ZHAMG S L. Association between p53 codon 72 polymorphism and cervical cancer risk among Asians: a HuGE review and meta-analysis[J]. Asian Pac J Cancer Prev,2012,13(10):4909-4914.
[34]HABBOUS S, PANG V, ENG L, et al. p53 Arg72Pro
polymorphism, HPV status and initiation, progression, and development of cervical cancer: a systematic review and Meta-analysis[J]. Clin Cancer Res,2012,18(23):6407-6415. |
|
|
|
