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| An analysis on the risk factors of discontinued therapy amongpatients with multi-drug resistant pulmonary tuberculosis |
| PENG Ying, CHEN Song-hua, CHEN Bin, ZHANG Ming-wu, WANG Fei, HE Tie-niu, ZHOU Lin, WANG Xiao-meng
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| The Center for Disease Control and Prevention of Zhejiang Province, Hangzhou, Zhejiang, 310051, China |
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Abstract Objective To analyze the basic characteristics of the therapy discontinued patients with multi-drug resistant pulmonary tuberculosis (MDR-TB) and to find the causes of therapy discontinuing. Methods Using case-control study method, a questionnaire survey was conducted to analyze the causes of MDR-TB in the treatment of interruption, and to compare the characteristics with the treatment completed patients, and to analyze the risk factors of discontinued therapy among MDR-TB patients. Results The study included 45 cases of therapy discontinued MDR-TB patients, and 45 cases of MDR-TB patients who had completed the treatment as the control. Multivariate logistic regression analysis results showed that patients with over 65 years old(OR=8.69, 95% CI=1.12,67.57), leak medication or drug withdrawal experience (OR=53.18,95% CI=5.90,479.27), were the risk factors of discontinued therapy(P<0.05). Patients with hospitalization for over 15 days was the protective factors for discontinued therpy(OR=0.09, 95% CI=0.01,0.58), (P<0.05). Conclusion advanced age≥65 years old, low income, leak medication or drug withdrawal experience short hospitalization periods were related to the risk of MDR-TB patients therapy discontinuing. were the key targets for patient management in the future.
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Received: 18 February 2016
Published: 20 December 2017
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