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| A study on the correlation between serum ENA-78 expression and pelvicinflammatory adhesion and pain grading among patients with endometriosis |
| SHEN Shuang-shuang, YANG Qun-ai, ZHUGE Li-fang, CHEN Xu-hua
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| Department of Obstetrics and Gynecology, Jinhua maternity and child care center, Jinhua, Zhejiang,321000, China |
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Abstract Objective To observe the changes of ENA-78 expression levels in patients with endometriosis (EM) before and after treatment, and the role of ENA-78 expression in pain and pelvic inflammation. Methods A total of 160 patients with EM were selected as the research subjects for I phase, II phase, III phase, IV phase patients. In the same period, 40 cases of non EM patients were selected as control group. Serum ENA-78 expression levels were detected among patients with EM before treatment, 3 months after treatment and 6 months after treatment, and the control group before treatment by the method of ELISA .The correlation between ENA-78 expression and pelvic inflammatory adhesion and pain grading among patients with EM was analyzed. Results There was significant difference in the level of serum ENA-78 expression between the two groups at different time points (P<0.01). The expression level of serum ENA-78 of case group decreased with time (P<0.01), while the expression level of serum ENA-78 of EM patients with different pain grading was different (P< 0.05). The expression level of ENA-78 in severe group was higher than that in mild group and moderate group (P< 0.05). The degree of pelvic adhesion in EM patients was positively correlated with the level of ENA-78 expression (rs=0.675, P=0.000).The expression of ENA-78 in serum of EM patients with different degrees of pelvic inflammation was different (P<0.05), and the expression of V-grade group ENA-78 was higher than other groups (P< 0.05). The level of ENA-78 expression was positively correlated with the degree of pain in patients with EM (rs=0.601, P=0.000). Conclusion Serum ENA-78 expression levels among EM patients were high, and positively correlated with pelvic inflammatory adhesion and pain grading. Serum ENA-78 decreased after GnRh-a treatment.
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Received: 11 April 2016
Published: 11 December 2017
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