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| Mechanism of immune regulation disorder in the development of atherosclerosis induced by occupational stress |
| CHEN Jing, HUANG Yujie, YAN Yuan, YIN Yangguang
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| Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing 400060, China |
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Abstract Research has shown that occupational stress is closely related to the occurrence and progression of atherosclerosis, with immune dysregulation serving as a mediating factor. Occupational stress triggers immune dysregulation in the body, ultimately leading to atherosclerosis through mechanisms such as the activation of immune cells and inflammatory mediators, endothelial dysfunction, and lipid metabolism disorders. This article reviews the primary mechanisms by which immune dysregulation plays a role in atherosclerosis caused by occupational stress, providing the reference for the prevention and intervention of atherosclerosis.
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Received: 12 August 2024
Revised: 05 November 2024
Published: 13 December 2024
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[1] VIRANI S S,ALONSO A,BENJAMIN E J,et al.Heart disease and stroke statistics-2020 update:a report from the American Heart Association[J/OL].Circulation,2020,141(9)[2024-11-05].https://doi.org/10.1161/CIR.0000000000000757.
[2] MUNTANER C,NIETO F J,COOPER L,et al.Work organization and atherosclerosis:findings from the ARIC study.Atherosclerosis risk in communities[J].Am J Prev Med,1998,14(1):9-18.
[3] SIEGRIST J,MATSCHINGER H,CREMER P,et al.Atherogenic risk in men suffering from occupational stress[J].Atherosclerosis,1988,69(2/3):211-218.
[4] LU W H,ZHANG W Q,SUN F,et al.Correlation between occupational stress and coronary heart disease in northwestern China:a case study of Xinjiang[J/OL].Biomed Res Int,2021[2024-11-05].https://doi.org/10.1155/2021/8127873
[5] VON KÄNEL R,PRINCIP M,HOLZGANG S A,et al.Coronary microvascular function in male physicians with burnout and job stress:an observational study[J].BMC Med,2023,21(1):477-490.
[6] WANG W J,REN H,TIAN Q Y,et al.Effects of occupational stress on blood lipids,blood sugar and immune function of doctors[J].Iran J Public Health,2019,48(5):825-833.
[7] MAURICIO D,CASTELBLANCO E,ALONSO N.Cholesterol and inflammation in atherosclerosis:an immune-metabolic hypothesis[J].Nutrients,2020,12(8):2444-2447.
[8] SHAH P K.Inflammation,infection and atherosclerosis[J].Trends Cardiovasc Med,2019,29(8):468-472.
[9] AMERSFOORT J,EELEN G,CARMELIET P.Immunomodulation by endothelial cells-partnering up with the immune system?[J].Nat Rev Immunol,2022,22(9):576-588.
[10] CHENG M Y,POLLOCK R A,HENDRICK J P,et al.Import and processing of human ornithine transcarbamoylase precursor by mitochondria from Saccharomyces cerevisiae[J].Proc Natl Acad Sci USA,1987,84(12):4063-4067.
[11] LIBBY P.The changing landscape of atherosclerosis[J].Nature,2021,592(7855):524-533.
[12] 张奇,孙浩然,陆见霏,等.国内放射工作人员职业紧张研究现状[J].中国辐射卫生,2023,32(6):651-655.
[13] 刘傲荷,王会宁,阎腾龙,等.工作场所职业紧张风险评估方法探讨[J].中国职业医学,2023,50(6):626-631,639.
[14] BOSCOLO P,YOUINOU P,THEOHARIDES T C,et al.Environmental and occupational stress and autoimmunity[J].Autoimmun Rev,2008,7(4):340-343.
[15] SJÖRS DAHLMAN A,JONSDOTTIR I H,HANSSON C.The hypothalamo-pituitary-adrenal axis and the autonomic nervous system in burnout[J].Handb Clin Neurol,2021,182:83-94.
[16] FLYNN S,SRIKANTHAN P,RAVELLETTE K,et al.Urinary cortisol and cardiovascular events in women vs. men:the multi-ethnic study of atherosclerosis[J/OL].Am Heart J Plus,2023,36[2024-11-05].https://doi.org/.10.1016/j.ahjo.2023.100344.
[17] ZEFFERINO R,DI GIOIA S,CONESE M.Molecular links between endocrine, nervous and immune system during chronic stress[J/OL].Brain Behav,2021,11(2)[2024-11-05].https://doi.org/10.1002/brb3.1960.
[18] VALLEJO J,COCHAIN C,ZERNECKE A,et al.Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq[J].Cardiovasc Res,2021,117(13):2537-2543.
[19] PATRIKI D,SARAVI S S S,CAMICI G G,et al.PCSK 9:a link between inflammation and atherosclerosis[J].Curr Med Chem,2022,29(2):251-267.
[20] MONTARELLO N J,NGUYEN M T,WONG D T L,et al.Inflammation in coronary atherosclerosis and its therapeutic implications[J].Cardiovasc Drugs Ther,2022,36(2):347-362.
[21] XUE S,SU Z,LIU D C.Immunometabolism and immune response regulate macrophage function in atherosclerosis[J/OL].Ageing Res Rev,2023,90[2024-11-05].https://doi.org/10.1016/j.arr.2023.101993.
[22] MC AULEY M T.Modeling cholesterol metabolism and atherosclerosis[J/OL].WIREs Mech Dis,2022,14(3)[2024-11-05].https://doi.org/10.1002/wsbm.1546. |
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