肥胖、外周血血脂指标与非小细胞肺癌的孟德尔随机化研究

doi:10.19485/j.cnki.issn2096-5087.2024.06.014

Preventive Medicine

2024, Vol. 36

Issue (6): 518-522 DOI: 10.19485/j.cnki.issn2096-5087.2024.06.014

Disease Control

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Associations of obesity and peripheral blood lipid indicators with non-small cell lung cancer: a Mendelian randomization study

BAI Yong, LI Ping, JIANG Nan

Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

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Abstract Objective To examine the causal relationships between obesity, peripheral blood lipid indicators and non-small cell lung cancer (NSCLC) using Mendelian randomization (MR) method, so as to provide the basis for developing NSCLC prevention and control strategies. Methods Genetic variation data of three obesity evaluation indicators, including body mass index (BMI), body fat ratio (BFR) and waist-to-hip ratio (WHR), and seven peripheral blood lipid indicators, including triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and lipoprotein a [LP (a)] were collected through genome-wide association studies (GWAS) and related public databases. Potential causal relationships between obesity, peripheral blood lipid indicators and NSCLC were analyzed using inverse-variance weighted (IVW) method and multivariable MR analysis upon a random effect model. Heterogeneity and horizontal pleiotropy of instrumental variables were evaluated using Cochran's Q test and MR-Egger regression. Results There was statistically association between BMI with NSCLC (OR=1.256, 95%CI: 1.087-1.451); there were no statistically associations between BFR, WHR, seven peripheral blood lipid indicators and NSCLC (all P>0.005). There was heterogeneity in the association between BMI, BFR, WHR, TG, HDL-C and NSCLC (all P<0.05); no horizontal pleiotropy of instrumental variables was found (all P>0.05). There was no statistically association between BMI and NSCLC after adjusting BFR (OR=1.367, 95%CI: 0.878-2.128); there was still statistically association between BMI and NSCLC after adjusting WHR and peripheral blood lipid indicators (both P<0.05). Conclusions The increase of BMI is associated with the increased risk of NSCLC incidence. BFR may be a potential influencing factor for the association between BMI and NSCLC.

Key words： obesity blood lipid non-small cell lung cancer association body mass index body fat rate

Received: 04 December 2023 Revised: 22 March 2024 Published: 20 June 2024

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BAI Yong,LI Ping,JIANG Nan. Associations of obesity and peripheral blood lipid indicators with non-small cell lung cancer: a Mendelian randomization study[J]. Preventive Medicine, 2024, 36(6): 518-522.

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http://www.zjyfyxzz.com/EN/10.19485/j.cnki.issn2096-5087.2024.06.014 OR http://www.zjyfyxzz.com/EN/Y2024/V36/I6/518

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