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| Hepatitis B virus carriage among pregnant and lying-in womenin Cangnan County from 2011 to 2022 |
| JIN Yirong1, XU Shaohua2, CHEN Aizeng2, CHEN Yiming3
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1. Department of Infectious Disease Control and Prevention, Cangnan County Center for Disease Control and Prevention, Cangnan, Zhejiang 325800, China;
2. The Third People's Hospital of Cangnan County, Cangnan, Zhejiang 325804, China;
3. Hangzhou Women's Hospital, Hangzhou, Zhejiang 310008, China |
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Abstract Objective To investigate the prevalence of hepatitis B virus (HBV) carriage among pregnant and lying-in women in Cangnan County, Zhejiang Province from 2011 to 2022 and identify the influencing factors, so as to provide insights into the guidance of healthcare among HBV carriers during pregnancy. Methods A total of 34 403 women delivered in The Third People's Hospital of Cangnan County from January 2011 to July 2022 were enrolled, and their demographics, HBV carriage and pregnant outcomes were collected. The prevalence of HBV carriage was analyzed among pregnant and lying-in women, and factors affecting HBV carriage were identified using a multivariable logistic regression model. Results A total of 34 403 pregnant and lying-in women were enrolled, with a median age of 27.00 (interquartile range, 7.00) years, and including 8 118 floating populations (23.60%). The overall prevalence of HBV carriage was 3.44%, and the prevalence of HBV carriage was 1.59% from 2011 to 2014, 4.08% from 2015 to 2018 and 6.86% from 2019 to 2022, appearing a tendency towards a rise (P<0.05). Multivariable logistic regression analysis identified estimated age of delivery (20-24 years, OR=1.832, 95%CI: 1.037-3.235; 25-29 years, OR=2.404, 95%CI: 1.372-4.214; 30-34 years, OR=2.914, 95%CI: 1.656-5.129; 35-39 years, OR=3.116, 95%CI: 1.741-5.576; 40 years and older, OR=2.358, 95%CI: 1.145-4.858), floating population (OR=0.670, 95%CI: 0.574-0.782), scarred uterus after cesarean section (OR=1.228, 95%CI: 1.076-1.521) and year of delivery (from 2015 to 2018, OR=2.504, 95%CI: 2.143-2.926; from 2019 to 2022, OR=4.425, 95%CI: 3.779-5.182) as factors affecting HBV carriage among pregnant and lying-in women. Conclusions The prevalence of HBV carriage rate appeared a tendency towards a rise among pregnant and lying-in women in Cangnan County from 2011 to 2022. Estimated age of delivery, floating population, year of delivery and scarred uterus after cesarean section are factors affecting HBV carriage.
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Received: 15 May 2023
Revised: 28 September 2023
Published: 12 January 2024
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[1] CUI F Q,BLACH S,MANZENGO M C,et al.Global reporting of progress towards elimination of hepatitis B and hepatitis C[J].Lancet Gastroenterol,2023,8(4):332-342.
[2] LIU Z H,CHEN Z D,CUI F Q,et al.Management algorithm for prevention of mother-to-child transmission of hepatitis B virus(2022)[J].J Clin Transl Hepatol,2022,10(5):1004-1010.
[3] 周洋,卢肇骏,严睿,等.应用德尔菲法构建乙型肝炎病毒感染孕产妇健康管理优化路径[J].预防医学,2022,34(6):631-636.
[4] CUI F Q,WOODRING J,CHAN P,et al.Considerations of antiviral treatment to interrupt mother-to-child transmission of hepatitis B virus in China[J].Int J Epidemiol,2018,47(5):1529-1537.
[5] AKHTER S,TALUKDER M Q,BHUIYAN N,et al.Hepatitis B virus infection in pregnant mothers and its transmission to infants[J].Indian J Pediatr,1992,59(4):411-415.
[6] WANG A L,QIAO Y P,WANG L H,et al.Integrated prevention of mother-to-child transmission for human immunodeficiency virus,syphilis and hepatitis B virus in China[J].Bull World Health Organ,2015,93(1):52-56.
[7] CHEN Y M,NING W W,WANG X,et al.Maternal hepatitis B surface antigen carrier status and pregnancy outcome:a retrospective cohort study[J/OL].Epidemiol Infect,2022,150[2023-09-28].https://doi.org/10.1017/S0950268822000681.
[8] SUN Q,LAO T T,DU M Y,et al.Chronic maternal hepatitis B virus infection and pregnancy outcome-a single center study in Kunming,China[J/OL].BMC Infect Dis,2021,21(1)[2023-09-28].https://doi.org/10.1186/s12879-021-05946-7.
[9] CUI A M,SHAO J G,LI H B,et al.Association of chronic hepatitis B virus infection with preterm birth:our experience and meta-analysis[J].J Perinat Med,2017,45(8):933-940.
[10] 王玉敏,姜晓凤.2009—2020年丹东市振安区乙型肝炎流行病学特征分析[J].中国实用乡村医生杂志,2021,28(8):25-28.
[11] 武文娟,张静,黄彩霞,等.2015—2019年城关区孕产妇梅毒和乙型病毒性肝炎检测结果[J].预防医学,2021,33(6):639-641,646.
[12] 宋春兰,吴睿,张国庆.1990—2014年寿光市乙肝流行特征分析[J].预防医学论坛,2015,21(7):555-556.
[13] 马岩,方益荣,王吉玲,等.2008—2018年绍兴市乙型病毒性肝炎流行趋势分析[J].预防医学,2020,32(1):1-3.
[14] PENG S X,WAN Z H,LIU T T,et al.Cesarean section reduces the risk of early mother-to-child transmission of hepatitis B virus[J].Dig Liver Dis,2018,50(10):1076-1080.
[15] WAN S,YANG M N,PEI J D,et al.Pregnancy outcomes and associated factors for uterine rupture:an 8 years population-based retrospective study[J/OL].BMC Pregnancy Childbirth,2022,22(1)[2023-09-28].https://doi.org/10.1186/s12884-022-04415-6. |
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