早产儿呼吸窘迫综合征肺表面活性物质治疗两种给药方法比较

doi:10.19485/j.cnki.issn2096-5087.2023.09.005

Preventive Medicine

2023, Vol. 35

Issue (9): 757-761 DOI: 10.19485/j.cnki.issn2096-5087.2023.09.005

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Comparison of the effectiveness of two pulmonary surfactant administration methods among premature infants with respiratory distress syndrome

ZHANG Yanli¹, ZHU Peng², YANG Rong¹, WANG Xinxin¹, YIN Xiaoguang¹

1. Department of Neonatology, Anhui Provincial Maternity and Child Health Hospital, Hefei, Anhui 230001, China;
2. School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China

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Abstract Objective To compare the effectiveness of less invasive surfactant administration (LISA) and intubate surfactant extubation (INSURE) on respiratory distress syndrome (RDS) among premature infant, so as to provide insights into improving treatment effects and reducing complications of RDS among premature infants. Methods A total of 71 premature infants with RDS in Anhui Provincial Maternity and Child Health Hospital were randomly assigned into the LISA and INSURE group, and pulmonary surfactant (PS) administration was carried out by LISA and INSURE with basic support therapy and respiratory support therapy. The general information, arterial blood gas analysis before and after treatment, respiratory support time and incidence of complications were collected and compared between the two groups. Results There were 31 cases in the LISA group, with a gestational age of (29.81±0.99) weeks and 22 male cases, and 40 cases in the INSURE group, with a gestational age of (30.02±1.13) weeks and 26 male cases. There were no significant differences in basic characteristics (including gestational age, birth weight, gender, etc.) between the two groups (all P>0.05). After administration, the level of PaO₂ was lower in the LISA group than in the INSURE group [(78.35±6.55) mmHg vs. (87.68±8.21) mmHg, P<0.05], the level of PaCO₂ was higher in the LISA group than in the INSURE group [(43.03±6.34) mmHg vs. (38.68±9.69) mmHg, P<0.05], and the incidence of bronchopulmonary dysplasia was lower in the LISA group than in the INSURE group (48.39% vs. 72.50%, P<0.05). Linear regression analysis showed that with the duration of LISA administration increase (2-7 min), the minimum heart rate of premature infants increased linearly (β=13, P<0.05). Conclusions Compared with INSURE, LISA administration could slowly improve ventilation oxygenation, reduce hyperventilation and incidence of bronchopulmonary dysplasia among premature infants with RDS. The incidence of slow heart rate may be reduced by appropriately prolonging the administration duration.

Key words： premature infant respiratory distress syndrome less invasive surfactant administration intubate surfactant extubate

Received: 28 June 2023 Revised: 02 August 2023 Published: 06 September 2023

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	ZHANG Yanli
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Cite this article:

ZHANG Yanli,ZHU Peng,YANG Rong, et al. Comparison of the effectiveness of two pulmonary surfactant administration methods among premature infants with respiratory distress syndrome[J]. Preventive Medicine, 2023, 35(9): 757-761.

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http://www.zjyfyxzz.com/EN/10.19485/j.cnki.issn2096-5087.2023.09.005 OR http://www.zjyfyxzz.com/EN/Y2023/V35/I9/757

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