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Epidemiological features of hand, foot, and mouth disease among children under 6 years in Wuxing District |
QIAN Xiaoping, LING Jian, LIU Teng
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Department of Immunization Planning, Wuxing Center for Disease Control and Prevention, Huzhou, Zhejiang 313000, China |
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Abstract Objective To investigate the epidemiological characteristics of hand, foot, and-mouth disease (HFMD) among children under 6 years in Wuxing District, Huzhou City from 2013 to 2021, so as to provide insights into HFMC control among children. Methods The surveillance on HFMD and enterovirus 71 (EV71) vaccination among children under 6 years in Wuxing District, Huzhou City from 2013 to 2021 were captured from China Disease Prevention and Control Information System, and the temporal, human and spatial distributions of HFMD cases and pathogenic detection results were descriptively analyzed. Results A total of 14 272 HFMD cases under 6 years were reported in Wuxing District from 2013 to 2021, with an average annual incidence rate of 465.75/104. There were 8 313 male children with HFMD (522.39/104 incidence) and 5 959 female children with HFMD (404.55/104 incidence), and higher incidence of HFMD was seen among male children than among female children (χ2=239.228, P<0.001). Most HFMD cases were found among children at ages of 1 to 3 years (10 006 cases, 70.11%), and the incidence of HFMD peaked during the period between May and July and between October and December each year. High incidence of HFMD was seen in Zhili Township (741.50/104), Yangjiabu Street (546.99/104) and Balidian Township (438.68/104). There were 717 laboratory-confirmed HFMD cases (5.02%), including 106 EV71-positive cases (14.78%) and 177 CoxA16-positive cases (24.69%). A total of 56 288 doses of EV71 vaccines were administered in Wuxing District from 2017 to 2021, with an annual average full-dose vaccination rate of 14.87%. The detection of EV71 infection was significantly lower after EV71 vaccination than before vaccination (4.49% vs. 24.93%; χ2=62.932, P<0.001). Conclusions The incidence of HFMD peaks in summer and winter among children under 6 years in Wuxing District, which predominantly occurs among children at ages of 1 to 3 years. The incidence of HFMD is high in Zhili Township, Yangjiabu Street and Balidian Township, and the number of EV71-positive cases significantly reduces after EV71 vaccination than before vaccination.
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Received: 04 November 2022
Revised: 13 January 2023
Published: 17 March 2023
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[1] COX B,LEVENT F.Hand,foot,and mouth disease[J/OL].JAMA,2018,320(23)[2023-01-13].https://doi.org/10.1001/jama.2018.17288. [2] 杭惠,张钧,陈立凌,等.2011—2020年苏州市6岁以下儿童手足口病流行特征分析[J].中国初级卫生保健,2022,36(5):51-54. [3] 张万军,袁兆虎,张瑾,等.2008—2017年镇江市6岁以下儿童手足口病流行特征及病原学监测分析[J].现代预防医学,2019,46(2):360-367. [4] 庞孟涛,李傅冬,林君芬,等.2016—2019年浙江省手足口病流行特征[J].预防医学,2022,34(3):307-310. [5] 王笑笑,蔡剑,韩桃利,等.2009—2017年浙江省手足口病流行病学特征及病原学监测分析[J].中华实验和临床病毒学杂志,2019,33(1):1-5. [6] 陈诹,王莉红,刘丹,等.2015—2018年上海市浦东新区手足口病空间特征分析[J].公共卫生与预防医学,2020,31(2):50-53. [7] 王浩权,马飞飞,龚刚,等.2015—2020年嘉定区手足口病流行特征[J].预防医学,2021,33(10):1065-1067. [8] 刘立立,刘志科,张良,等.2016—2019年宁波市5岁及以下儿童手足口病流行病学特征[J].北京大学学报(医学版), 2021,53(3):491-497. [9] 孙巍,陈淑红,华华,等.2018—2019年黑龙江省手足口病疫情特征分析[J].中国公共卫生管理,2021,37(6):796-798. [10] 袁百利. 关于吴兴区流动人口公共卫生管理思路的探索[C]//浙江省第十七届农村医学暨乡镇卫生院管理学术会议大会论文集,2009:170-172. [11] 章光明,吴晓虹,金祝平,等.金华市EV71灭活疫苗接种水平分析[J].预防医学,2019,31(10):1022-1024. [12] 王凌虹,叶丽霞,顾永权,等.余姚市2012—2018年出生儿童肠道病毒71型疫苗接种分析[J].预防医学,2020,32(9):911-916. [13] 杨芬,梁文佳,孙立梅,等.广东省EV71疫苗接种水平与手足口病流行分析[J].中国公共卫生,2020,36(3):351-354. |
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