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| Research progress of intestinal microorganisms and pathogenesis of diabetes mellitus |
| FANG Yuan, HA Xiaoqin
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| Clinical Laboratory, The 940th Hospital of Joint Logistics Support Force of Chinese People Liberation Amy, Lanzhou, Gansu 730000, China |
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Abstract As the largest human microecosystem, intestinal microorganisms participate in human material and energy metabolisms and pose a significant impact on human health. Diabetes mellitus is likely to cause imbalance of abundance and component alterations in intestinal microorganisms, and reduce the diversity and balance, leading to intestinal microflora dysregulation. It has been shown that intestinal microflora dysregulation may promote diabetes development and progression through the reduction of intestinal microbial metabolites, inflammatory reaction and insulin resistance. This review summarizes the involvement of intestinal microorganisms in the pathogenesis of diabetes through metabolites including short-chain fatty acid, bile acid and lipopolysaccharide, and describes the current status of intestinal microorganisms-mediated treatments for diabetes, so as to provide the theoretical basis for the researches on diabetes and intestinal microorganisms.
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Received: 17 September 2021
Revised: 27 December 2021
Published: 14 March 2022
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