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| Applications of functional genomics in research of benzo[a]pyrenetoxicity：a review |
| CAO Bin, SONG Yanhua
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| Department of Physicochemical and Toxicology, Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou, Zhejiang 310051, China |
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Abstract Benzo [a] pyrene ( B [a] P ) is a well-recognized environmental pollutant. Exposure to B[a]P elicits many adverse biological effects, including tumorigenesis, immunosuppression, teratogenicity, and hormonal effects. In addition to B [a] P exposure-induced genetic damages, a growing number of studies demonstrate that epigenetic changes play an important role in chemically induced carcinogenesis. In order to provide better understanding of epigenetic changes of B [a] P and their potential association with genotoxic endpoints, this review summarizes the advances in the applications of functional genomics in the research of B [a] P toxicity, including functional genomics techniques, regulation of human genome expression, DNA sequence variability, model organisms research, and bioinformatics studies, so as to provide insights into the management of B [a] P exposure-induced health injuries and use of genomics techniques to unravel the mechanisms underlying the toxicity of other environmental pollutants.
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Received: 19 July 2021
Revised: 12 November 2021
Published: 14 February 2022
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