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Incidence of new HIV infection and its influencing factors among men who have sex with men in China: a meta-analysis |
HE Jiajin1, JU Hao2, WU Chao3
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1. School of Public Health, Zhejiang University, Hangzhou, Zhejiang 310058, China; 2. School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; 3. School of Public Affairs, Zhejiang University, Hangzhou, Zhejiang 310058, China |
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Abstract Objective To investigate the incidence of new HIV infection and its influencing factors among men who have sex with men ( MSM ) in China, so as to provide the evidence for formulating the AIDS control strategy. Methods Cohort studies pertaining to new HIV infections among Chinese MSM populations were retrieved in Chinese and English electronic databases, including CNKI, Wanfang Data, VIP, PubMed, Web of Science, Embase and Cochrane Library, and the retrieval time was set to build the database until May 2021. A meta-analysis was performed to investigate the incidence of new HIV infection and its influencing factors among Chinese MSM populations. The publication bias was assessed using funnel plot and Egger's test, and the stability of outcome parameters was evaluated using sensitivity analysis. Results A total of 850 publications were retrieved, and 43 eligible literatures ( 44 studies ) were included in the final analysis. The pooled incidence of new HIV infection was 4.93 ( 95%CI: 4.15 to 5.72) per 100 person-years among Chinese MSM populations. Egger's test showed a publication bias ( t=2.411, P=0.021). Subgroup analysis revealed high incidence of new HIV infection in east ( 5.21 per 100 person-years ), north ( 5.30 per 100 person-years ) and southwest (4.84 per 100 person-years) China, and the lowest incidence in northwest China ( 2.87 per 100 person-years ), and showed higher incidence in first-tier cities ( 5.12 per 100 person-years ) than in nonfirst-tier cities ( 3.89 per 100 person-years ). Syphilis infection ( HR=3.41 ), unprotected anal sex ( HR=2.52 ), multiple sexual partners ( HR=3.51 ), seeking sex partners in bars, public baths and parks ( HR=3.44 ), age of > 25 years ( HR=0.44 ), Han Ethnicity ( HR=0.35 ), awareness of AIDS-related knowledge ( HR=0.20 ) and provision of HIV preventive services ( HR=0.18 ) were associated with new HIV infection in Chinese MSM populations. In addition, publication bias was found in studies reporting syphilis infection ( t=4.841, P<0.001 ), unprotected anal sex ( t=4.114, P=0.006 ) and ethnicity ( t=-5.018, P=0.038 ). Conclusions The incidence of new HIV infection is high among Chinese MSM populations. Interventions targeting the factors affecting new HIV infections are required to reduce in the incidence of new HIV infections among Chinese MSM populations.
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Received: 07 September 2021
Revised: 03 December 2021
Published: 12 January 2022
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[1] HESSOU P H S,YOLAINE G A,RHEDA A,et al.Comparison of the prevalence rates of HIV infection between men who have sex with men(MSM)and men in the general population in sub-Saharan Africa:a systematic review and meta-analysis[J/OL].BMC Public Health,2019,19(2019-12-04)[2021-12-03].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894288.DOI:10.1186/s12889-019-8000-x. [2] 中国疾病预防控制中心性病艾滋病预防控制中心性病控制中心.2018年第3季度全国艾滋病性病疫情[J].中国艾滋病性病,2018,24(11):1075. Chinese Center for Disease Control and Prevention.National Center for AIDS/STD Control and Prevention. Update on the AIDS/STD epidemic in China in the third quarter of 2018[J].Chin J AIDS STD,2018,24(11):1075. [3] STANG A.Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J].Eur J Epidemiol,2010,25(9):603-605. [4] LI D L,JIA Y J,RUAN Y H,et al.Correlates of incident infections for HIV,syphilis,and hepatitis B virus in a cohort of men who have sex with men in Beijing[J].AIDS Patient Care STDS,2010,24(9):595-602. [5] XU J J,ZHANG M,BROWN K,et al.Syphilis and HIV seroconversion among a 12-month prospective cohort of men who have sex with men in Shenyang,China[J].Sex Transm Dis,2010,37(7):432-439. [6] YANG H T,HAO C,HUAN X P,et al.HIV incidence and associated factors in a cohort of men who have sex with men in Nanjing,China[J].Sex Transm Dis,2010,37(4):208-213. [7] 张敏,闫红静,汪娜,等.南京市男男性行为人群随访中队列保持研究[J].中华疾病控制杂志,2011,15(10):839-842. ZHANG M,YAN H J,WANG N,et al.Incidence of HIV infection, retention rate in a prospective cohort among men who have sex with men in Nanjing[J].Chin J Dis Control Prev,2011,15(10):839-842. [8] 赵锦,蔡文德,陈珠蝶,等.深圳市男男性行为人群HIV、梅毒及HCV新发感染的队列研究[J].中国艾滋病性病,2011,17(5):530-532. ZHAO J,CAI W D,CHEN Z D,et al.A prospective cohort study on HIV,syphilis and HCV seroconversion among men who have sex with men in Shenzhen[J].Chin J AIDS STD,2011,17(5):530-532. [9] 李书明,周振海,姜树林,等.北京市男男性行为者HIV和梅毒螺旋体血清抗体阳转率及影响因素[J].中华预防医学杂志,2011,45(2):118-122. LI S M,ZHOU Z H,JIANG S L,et al.Incidence and risk factors of HIV and syphilis seroconversion among men who have sex with men in Beijing[J].Chin J Prev Med,2011,45(2):118-122. [10] HAO C,YAN H J,YANG H T,et al.The incidence of syphilis,HIV and HCV and associated factors in a cohort of men who have sex with men in Nanjing,China[J].Sex Transm Infect,2011,87(3):199-201. [11] HAN X X,XU J J,CHU Z X,et al.Screening acute HIV infections among Chinese men who have sex with men from voluntary counseling&testing centers[J/OL].PLoS One,2011,6(2011-12-14)[2021-12-03].https://doi.org/10.1371/journal.pone.0028792. [12] 李东亮,高彦杰,于明润,等.北京市男男性行为者HIV新发感染率及影响因素研究[J].中华流行病学杂志,2012,33(7):663-666. LI D L,GAO Y J,YU M R,et al.Study on the incidence of HIV and associated risk factors through a prospective cohort among men who have sex with men in Beijing,China[J].Chin J Epidemiol,2012,33(7):663-666. [13] 刘晓霞,张明辉,陈鑫,等.镇江市男男性行为人群前瞻性队列研究分析[J].中华疾病控制杂志,2012,16(12):1024-1027. LIU X X,ZHANG M H,CHEN X,et al.Analysis on the seroconversion of HIV/syphilis and the predictors of cohort retention among men who have sex with men in Zhenjiang,a prospective cohort study[J].Chin J Dis Control Prev,2012,16(12):1024-1027. [14] 任晖琴,地力夏提·亚克甫,米娜瓦尔·艾拜,等.乌鲁木齐市男男性行为人群HIV/STD新发感染率及其影响因素[J].新疆医科大学学报,2012,35(11):1495-1499. [15] 章任重,张琬悦,李佑芳,等.昆明市男男性行为人群艾滋病新发感染队列研究[J].中华预防医学杂志,2012,(10):955-957. ZHANG R Z,ZHANG W Y,LI Y F,et al.Cohort study of new HIV infection among MSM in Kunming City[J].Chin J Prev Med,2012,(10):955-957. [16] LI D L,LI S M,LIU Y J,et al.HIV incidence among men who have sex with men in Beijing:a prospective cohort study[J/OL].BMJ Open,2012,2(2012-11-19)[2021-12-03].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533041.DOI:10.1136/bmjopen-2012-001829. [17] PENG Z H,YANG H T,NORRIS J,et al.HIV incidence and predictors associated with retention in a cohort of men who have sex with men in Yangzhou,Jiangsu Province,China[J/OL].PLoS One,2012,7(12)(2012-12-28)[2021-12-03].https://doi.org/10.1371/journal.pone.0052731. [18] 蔡于茂,洪福昌,冯铁建,等.深圳市男男性行为人群HIV/梅毒发病密度研究[J].中国艾滋病性病,2013,19(2):125-126,137. CAI Y M,HONG F C,FENG T J,et al.Incidence density of HIV/syphilis among men who have sex with men in Shenzhen[J].Chin J AIDS STD,2013,19(2):125-126,137. [19] 蓝光华,刘伟,梁富雄,等.MSM HIV、梅毒、HSV-2新发感染及队列保持影响因素[J].中国公共卫生,2013,29(2):175-178. LAN G H,LIU W,LIANG F X,et al.Incidence of HIV,syphilis and HSV-2 among men who have sex with men in Nanning city:a follow-up study[J].Chin J Public Health,2013,29(2):175-178. [20] 李西婷,罗艳,武海滨,等.杭州市男男性行为人群HIV和梅毒螺旋体血清抗体阳转情况队列研究[J].疾病监测,2013,28(4):280-283. LI X T,LUO Y,WU H B,et al.A prospective cohort study on positive seroconversion of HIV and Treponema pallidum antibodies among men who have sex with men in Hangzhou[J].Dis Surveill,2013,28(4):280-283. [21] 王毅,李六林,樊静,等.绵阳市男男性行为者性行为和HIV感染及影响因素分析[J].实用预防医学,2013,20(10):1166-1169. WANG Y,LI L L,FAN J,et al.Investigation on the sexual behavior and HIV infection among MSM in Mianyang City and analysis of the influencing factors[J].Pract Prev Med,2013,20(10):1166-1169. [22] 赵涛,施建春,陈方方,等.南阳市MSM人群HIV新发感染情况研究[J].中国艾滋病性病,2013,19(1):39-42. ZHAO T,SHI J C,CHEN F F,et al.Study on incidence of new HIV infection among men who have sex with men in Nanyang[J].Chin J AIDS STD,2013,19(1):39-42. [23] 齐啸,徐杰,张政,等.北京市男男性行为人群HIV和梅毒本底感染及新发感染调查研究[J].中国预防医学杂志,2013,14(6):407-412. QI X,XU J,ZHANG Z,et al.Prevalence and incidence of HIV and syphilis among men who have sex with men in Beijing[J].Chin J Prev Med,2013,14(6):407-412. [24] 秦鸥,周健,袁飞,等.贵阳市MSM人群艾滋病感染危险因素分析和新发感染率调查[J].中国皮肤性病学杂志,2013,27(12):1261-1263. QIN O,ZHOU J,YUAN F,et al.HIV prevalence,associated risk factors and HIV incidence among MSM in Guiyang,China[J].Chin J Derm Venereol,2013,27(12):1261-1263. [25] XU J J,AN M H,HAN X X,et al.Prospective cohort study of HIV incidence and molecular characteristics of HIV among men who have sex with men(MSM)in Yunnan Province,China[J/OL].BMC Infect Dis,2013,13(2013-01-04)[2021-12-03].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599414.DOI:10.1186/1471-2334-13-3. [26] 傅卓华,赵秀萍,曹小平,等.苏州市男男性行为人群HIV新发感染队列研究[J].中国公共卫生,2014,30(6):726-728. FU Z H,ZHAO X P,CAO X P,et al.HIV incidence among men who have sex with men in Suzhou city:a cohort study[J].Chin J Public Health,2014,30(6):726-728. [27] 李建军,邱涛,刘晓燕,等.南京市男男性接触人群队列研究失访对发病率估计的影响[J].江苏卫生保健,2014,16(6):1-2. LI J J,QIU T,LIU X Y,et al.Influence of loss of follow-up on incidence estimation in nanjing MSM cohort study[J].Jiangsu Health Care,2014,16(6):1-2. [28] 唐慧玲,胡跃强,王凤英.金华市MSM队列HIV阳转及高危行为变化情况[J].中国艾滋病性病,2014,20(10):763-765,778. TANG H L,HU Y Q,WANG F Y.Changes of high risk behaviors and HIV seroconversion in a prospective MSM cohort in Jinhua[J].Chin J AIDS STD,2014,20(10):763-765,778. [29] 王毅,李六林,徐杰,等.四川省绵阳市男男性接触者HIV新发感染队列研究[J].中国病毒病杂志,2014,4(3):218-225. WANG Y,LI L L,XU J,et al.A cohort study of new HIV infections among men who have sex with men in Mianyang city,Sichuan province of China[J].Chin J Viral Dis,2014,4(3):218-225. [30] 钟斐,徐慧芳,秦发举,等.广州市2000—2010年男男性行为人群艾滋病流行状况分析[J].热带医学杂志,2014,14(3):353-357. ZHONG F,XU H F,QIN F J,et al.Analysis of HIV prevalence among men who have sex with men in Guangzhou from 2000 to 2010[J].J Trop Med,2014,14(3):353-357. [31] MAO H Y,MA W Z,LU H Y,et al.High incidence of HIV and syphilis among migrant men who have sex with men in Beijing,China:a prospective cohort study[J/OL].BMJ Open,2014,4(9)(2014-09-16)[2021-12-03].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166416.DOI:10.1136/bmjopen-2014-005351. [32] WANG Q Q,CHEN X S,YIN Y P,et al.HIV prevalence,incidence and risk behaviours among men who have sex with men in Yangzhou and Guangzhou,China:a cohort study[J/OL].J Int AIDS Soc,2014,17(2014-08-06)[2021-12-03].https://doi.org/10.7448/IAS.17.1.18849. [33] DONG Z X,XU J,ZHANG H B,et al.HIV incidence and risk factors in Chinese young men who have sex with men-a prospective cohort study[J/OL].PLoS One,2014,9(5)(2014-05-30)[2021-12-03].https://doi.org/10.1371/journal.pone.0097527. [34] 惠珊,李一,闫红梅,等.哈尔滨市男男性行为人群HIV新发感染及失访影响因素分析[J].中华流行病学杂志,2015,36(12):1381-1383. HUI S,LI Y,YAN H M,et al.HIV incidence and factor related to lost-to-follow-up among men who have sex with men in Harbin,Heilongjiang[J].Chin J Epidemiol,2015,36(12):1381-1383. [35] 王毅,李六林,徐杰,等.四川省绵阳市男男性行为人群队列研究HIV新发感染及影响因素[J].中华预防医学杂志,2015,49(1):66-70. WANG Y,LI L L,XU J,et al.Analysis on the HIV new infections and factors of men who have sex with men in Mianyang city,Sichuan province[J].Chin J Prev Med,2015,49(1):66-70. [36] 赵立华,蒋岸,张蕴慧,等.宁夏男男性行为者HIV新发感染及影响因素分析[J].中国皮肤性病学杂志,2015,29(1):50-52. ZHAO L H,JIANG A,ZHANG Y H,et al.Study on incidence of HIV and its influencing factors among MSM in Ningxia[J].Chin J Derm Venereol,2015,29(1):50-52. [37] JIA Z W,HUANG X J,WU H,et al.HIV burden in men who have sex with men:a prospective cohort study2007-2012[J/OL].Sci Rep,2015,5(2015-07-02)[2021-12-03].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393284.DOI:10.1038/srep11205. [38] 周良佳,闫红静,徐金水,等.南京市MSM人群HIV新发感染情况及影响因素分析[J].中华疾病控制杂志,2016,20(4):333-336,356. ZHOU L J,YAN H J,XU J S,et al.HIV incidence and its associated factors among MSM in Nanjing[J].Chin J Dis Control Prev,2016,20(4):333-336,356. [39] 刘雪梅,黎明强,韦东旭,等.柳州市男男性行为队列人群HIV感染影响因素分析[J].中华疾病控制杂志,2017,21(12):1232-1235. LIU X M,LI M Q,WEI D X,et al.Cohort study on the influential factors of HIV infection among men who have sex with men in Liuzhou City[J].Chin J Dis Control Prev,2017,21(12):1232-1235. [40] 马婧,李佑芳,章任重,等.昆明市2012-2016年MSM中HIV新发感染队列研究[J].中国艾滋病性病,2017,23(8):755-757,763. MA J,LI Y F,ZHANG R Z,et al.HIV incidence among men who have sex with men in Kunming city by a cohort study during 2012 to 2016[J].Chin J AIDS STD,2017,23(8):755-757,763. [41] 郭巍,李一,周宁,等.男男性行为人群艾滋病病毒新发感染风险的队列研究[J].中华流行病学杂志,2018,39(1):16-20. GUO W,LI Y,ZHOU N,et al.Risk factors related to HIV new infections among men who have sex with men in a cohort study[J].Chin J Epidemiol,2018,39(1):16-20. [42] YANG Z R,LI J,DONG Z Q,et al.Correlates of recent HIV infection among men who have sex with men recruited through the internet in Huzhou City,Eastern China[J].J Int Med Res,2018,46(12):5052-5061. [43] 殷方兰,钟培松,张永,等.上海市嘉定区男男性行为者HIV新发感染及队列保持影响因素研究[J].中国艾滋病性病,2019,25(9):947-950. YIN F L,ZHONG P S,ZHANG Y,et al.HIV incidence,retention rate and related factors in a cohort study among men who have sex with men in Shanghai suburb[J].Chin J AIDS STD,2019,25(9):947-950. [44] LI Q C,LI X T,LUO Y,et al.HIV incidence and cohort retention among men who have sex with men in Hangzhou,China:a prospective cohort study[J/OL].Medicine(Baltimore),2019,98(2019-10-04)[2021-12-03].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783165.DOI:10.1097/MD.0000000000017419 [45] 赵丹鹤. 北京市男男性行为者HIV新发感染与检测相关性的队列研究[J].沈阳医学院学报,2020,22(5):437-440,445. ZHAO D H.Relationship between HIV incidence and test among men who have sex with men in Beijing:a cohort study[J].J Shenyang Med Coll,2020,22(5):437-440,445. [46] MI G D,ZHANG B B,YU F,et al.HIV incidence among men who have sex with men using geosocial networking smartphone application in Beijing,China:an open cohort study[J/OL].Infect Dis Poverty,2021,10(2021-04-02)[2021-12-03].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017803.DOI:10.1186/s40249-021-00814-7. [47] 王遵伍,刘慧君,王莹.中国艾滋病流行的空间分布及集聚特征[J].中国公共卫生,2019,35(12):1593-1597. WANG Z W,LIU H J,WANG Y.Spatial distribution and clustering characteristics of AIDS epidemic in China,2005-2017[J].Chin J Public Health,2019,35(12):1593-1597. [48] ZHANG L,CHOW E P F,JAHN H J,et al.High HIV prevalence and risk of infection among rural-to-urban migrants in various migration stages in China:a systematic review and meta-analysis[J].Sex Transm Dis,2013,40(2):136-147. [49] 王丽艳,单多,葛增,等.少数民族地区艾滋病病毒感染者艾滋病相关知识及危险性行为调查[J].实用预防医学,2010,17(1):23-26. WANG L Y,SHAN D,GE Z,et al.Survey on AIDS awareness and risky sexual behaviors among PLWHA in minority areas in China[J].Pract Prev Med,2010,17(1):23-26. [50] 江光煚,吴国辉,裴迎新,等.中国老年人群HIV感染现况及行为学特征研究进展[J].实用预防医学,2019,26(4):510-513. JIANG G J,WU G H,PEI Y X,et al.Current status of HIV infection and research progress on behavioral characteristics among elderly people in China[J].Pract Prev Med,2019,26(4):510-513. |
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