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| Development of vaccines against COVID-19 |
| ZHU Yao*, WEI Yina, SUN Chang, HE Hanqing
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| *Department of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China |
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Abstract Since coronavirus disease 2019 (COVID-19) broke out, the world has accelerated the development of preventive vaccines. By December 2020, 60 candidate vaccines have been approved for clinical trials, of which 7 vaccines, including 3 inactivated vaccines, 2 mRNA vaccines and 2 vector vaccines, have been authorized for emergency use or conditional marketing. In this paper, we reviewed the development progress in inactivated vaccines, nucleic acid vaccines, vector vaccines, protein subunit vaccines, attenuated vaccines and virus-like particle vaccines, as well as advantages and disadvantages of these vaccines. The studies showed that the vaccines against COVID-19 in phase III clinical trials had good safety and immunogenicity, and those authorized vaccines were declared to have good efficacy. However, attention should be paid to the adverse reactions of the vaccines and the long-term protective effects, in order to improve the immunization strategy for the control of COVID-19 epidemic.
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Received: 10 December 2020
Revised: 07 January 2021
Published: 01 February 2021
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