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| Survival rate and influencing factors of HIV/AIDS after highly active antiretroviral therapy in Yinzhou District |
| WANG Bin, GONG Deguang, ZHU Jiequn
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| Yinzhou Center for Disease Control and Prevention,Ningbo,Zhejiang 315100, China |
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Abstract Objective To analyze the survival rate and its influencing factors of HIV/AIDS patients after antiviral therapy in Yinzhou District of Ningbo,so as to provide basis for AIDS prevention and control. Methods The data of HIV/AIDS patients who received highly active antiretroviral therapy（HAART）in Yinzhou District from May 2005 to December 2014 were retrieved from the national AIDS comprehensive prevention and control information system;the survival rate was calculated by life table and Kaplan-Meier analysis;the influencing factors for survival time was analyzed by a multivariate cox proportional risk regression model. Results Among 327 HIV/AIDS patients,twenty four were dead and three were lost. The average follow-up time was（5.63 ± 1.98）years. The cumulative survival rates of the subjects were 95%,92%,and 90% at 1,5,and 10 years after HAART. The Results of multivariate cox proportional risk regression analysis showed that patients who were at younger age when treatment begins（HR=1.053,95%CI: 1.001-1.108）,were transmitted by homosexual contact（HR=0.026,95%CI: 0.003-0.253）and by blood transmission（HR=0.043,95%CI: 0.006-0.309）,had high level of CD4+T lymphocyte at baseline（HR=0.993,95%CI: 0.988-0.998),and had viral load below the detection limit after six months of treatment（HR=0.028,95%CI: 0.009-0.084）were less likely to be dead. Conclusions The survival rate of HIV/AIDS patients after HAART is high,and is associated with the age when treatment begins,route of transmission,baseline CD4+T lymphocyte level and viral load after six months of treatment.
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Received: 02 December 2019
Revised: 02 January 2020
Published: 16 April 2020
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[1] 中国疾病预防控制中心性病艾滋病预防控制中心.联合国艾滋病规划署发布全球艾滋病最新情况报告 2018年全球疫情[EB/OL].( 2019-07-17 )[2020-01-02]. http://www.aidschannel.cn/article_554.html.
[2] 王陇德. 艾滋病学[M]. 北京: 北京出版社,2009:300.
[3] KITAHATA M M,GANGE S J,ABRAHAM A G,et al.Effect of early versus deferred antiretroviral therapy for HIV on survival[J]. N Engl J Med,2009,360(18):1815-1826.
[4] 陈婧,徐敏,赵啸,等. 北京市2005—2015年艾滋病抗病毒治疗患者生存及其影响因素[J]. 中华疾病控制杂志,2018,22(12): 1225-1228.
[5] 徐园园,李小衫,吴苏姝,等. 南京市2004—2016年接受抗病毒治疗HIV/AIDS患者生存分析[J]. 中国公共卫生,2018,34(4): 473-478.
[6] 孔维宾,韩丹,孙浩,等. 2003—2014年开封市艾滋病抗病毒治疗患者生存分析[J]. 河南大学学报(医学版),2015,34(2): 128-132.
[7] 中国疾病预防控制中心性病艾滋病预防控制中心.国家免费艾滋病抗病毒药物治疗手册[M]. 3版. 北京:人民卫生出版社,2012:17.
[8] 崔倩,俞文祥,祁耀,等. 盐城市2005—2015年艾滋病抗病毒治疗患者生存分析[J]. 实用预防医学,2018,25(5): 538-541.
[9] 豆智慧,张福杰,赵燕,等. 2002—2014年中国免费艾滋病抗病毒治疗进展[J]. 中华流行病学杂志,2015,36(12): 1345-1350.
[10] EGGER M,MAY M,CHENE G,et al.Prognosis of HIV-1- infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies[J]. Lancet,2002,360(9327) : 119-129.
[11] LEWDEN C,BOUTELOUP V,DE WIT S,et al.All-cause mortality in treated HIV-infected adults with CD4≥500/m3 compared with the general population: evidence from a large European observational cohort collaboration[J]. Int J Epidemiol,2012,41(2) : 433-445.
[12] CARRIQUIRY G,FINK V,KOETHE J R,et al.Mortality and loss to follow-up among HIV-infected persons on long-term antiretroviral therapy in Latin America and the Caribbean[J]. J Int AIDS Soc,2015,18(1) : 20016.
[13] SULIGOI B,ZUCCHETTO A,GRANDE E,et al.Risk factors for early mortality after AIDS in the cART era: a population-based cohort study in Italy[J].BMC Infect Dis,2015,15 : 229.
[14] 赖碎丽,邹伟军,梅利纯,等.青田县经性接触传播艾滋病流行特征分析[J].预防医学,2018,30(8):822-824.
[15] 王斌,周碧波. HIV新发感染者中主动检测与被动检测构成情况分析[J].中国艾滋病性病,2018,24(7): 729-730,748.
[16] SOHN A H,SRIKANTIAH P,SUNGKANUPARPH S,et al.Transmitted HIV drug resistance in Asia[J].Curr Opin HIV AIDS,2013,8(1) : 27-33.
[17] ZHAO J,CHEN L,CHAILLON A,et al.The dynamics of the HIV epidemic among men who have sex with men (MSM)from 2005 to 2012 in Shenzhen,China[J].Sci Rep,2016,6: 28703.
[18] CHEN M,MA Y,SU Y,et al.HIV-1 genetic characteristics and trasmitted drug resistance among men who have sex with men in Kunming,China[J].PLoS One,2014,9(1): e87033.
[19] HUANG W,DE GRUTTOLA V,FISCHL M,et al.Patterns of plasma human immunodeficiency virus type I RNA response to antiretroviral therapy[J]. J Infect Dis,2001,183(10): 1455-1465.
[20] 金玫华,杨中荣,李婧,等. 湖州市艾滋病患者抗病毒治疗服药依从性分析[J].预防医学,2018,30(12): 1231-1233. |
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