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| Effects of a nutritional complex on tumor growth and immune function in tumor-bearing mice |
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YANG Ren-hua,YIN Xuan
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| Hangzhou First People's Hospital,Affiliated Hospital for Medical School of Zhejiang University,Hangzhou,Zhejiang 310006,China |
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Abstract Objective To explore the effects of a complex made from lily,glutinous rice,black bean,red jujube,whey protein powder and spirulina on tumor growth and immune function in C57BL/6 tumor-bearing mice,so as to provide evidence for nutrition intervention on tumor sufferers. Methods Twenty-four C57BL/6 male tumor-bearing mice were divided into three dose groups and a control group. The mice in the low,medium and high dose group was fed with 8 g/kgbw,20 g/kgbw and 40 g/kgbw complex,respectively;the mice in the control group was fed with 0.5% CMC-Na. All mice were intragastrically administered for seven days,and the weight gain,tumor volume,tumor weight,tumor inhibition rate,thymus index,spleen index,T lymphocyte proliferation,NK cell killing rate and interleukin-2 expression were measured. Results The tumor weights of the mice in the three dose groups wereall less than that in the control group（P<0.05）. The numbers of CD3+ T cells in the three dose groups were more than that in the control group（P<0.05）. The tumor inhibition rates of the low,medium and high dose groupwere 32.46%,45.14% and 48.03%,respectively. The optical density,NK cell killing rates,IL-2 expression of spleen cells and the number of T lymphocyte subsets were dose-dependent（P<0.05）. Compared with the control group,the mice in the medium and high dose group had higher thymus indexes,NK cell killing rates,IL-2 expression of spleen cells,CD4+T cell levels and CD4+ to CD8+ ratios,but lower tumor volumes and CD8+ T cell levels（P<0.05）;the mice in the high dose group had higher optical density（P<0.05）. Conclusion This nutritional complex may play an anti-tumor role by regulating the immune function of tumor-bearing mice.
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Received: 09 April 2019
Revised: 12 July 2019
Published: 26 September 2019
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