|
|
|
| A study on the correlations study among HOMA-IR, obesity and inflammatory factors among middle aged and elderly population |
| SHI Xiao-feng, WANG San-zhong, YU Xin-fen, SHEN Hua, PAN Qin-mei, SHEN Zhi-xing, SHEN Di-sheng1, CHEN Gong-ying3
|
| 1. The hospital of Lianshi,Huzhou,Zhejiang,313013,China. |
|
|
|
|
Abstract Objective To investigate the distribution of insulin resistance （HOMA-IR） index and its influencing factors among middle and old aged people with normal glucose and to provide the basis for early screening and prevention of type 2 diabetes. Methods A total of 229 residents were selected with health records showed normal blood glucose （fasting blood glucose < 7.0mmol/L,postprandial 2h blood glucose<11.1 mmol/L） and more than 40 years old from July, 2012 to June,2015. Height,weight, waist and hip circumference, and the fasting plasma glucose （FPG）,insulin （FINS）,low density lipoprotein （LDL）,uric acid,tumor necrosis factor （TNF） and interleukin -6 （IL-6）were recorded to analyze the distribution of HOMA-IR and its influencing factors. Results Totally 229 people were included,of which 113 were male（49.34%）,116 female（50.66%）. The average age was（63.58 + 8.85）years old. The average HOMA-IR index was 0.94 （1.08）and there were 21 people that HOMA-IR exceed the standard （HOMA-IR≥2.68）,accounting for 9.17%.The HOMA-IR index of different gender,age,waist circumference,hip circumference,uric acid in the elderly had significant difference （P < 0.05）.Multiple linear regression analysis showed that HOMA-IR index was positively correlated with female,waist circumference and IL-6 and was negatively correlated with age. Conclusion The possibility of IR was higher in women with relatively low age,female,central obesity and high IL-6 levels among the middle and old aged people with normal blood glucose.
|
|
Received: 13 September 2016
Revised: 14 November 2016
Published: 27 October 2017
|
|
|
|
|
|
[1] MATTHEWS D R, HOSKER J P, RUDENSKI A S, et al. Homeostasis model assessment：insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man[J]. Diabetologia,1985,28（7）：412- 419.
[2] 陈春明,孔灵芝. 中国成人超重和肥胖症预防控制指南[M].北京：人民卫生出版社,2006.
[3] 杜艳爽,陈立琴,闫洪泉,等. 健康干预对糖尿病危险因素及其发病率的影响[J]. 护理研究,2010,24（19）：1749-1750.
[4] 周智广,冯琼. 肥胖合并糖尿病的临床表现及诊断进展[J]. 临床内科杂志,2012,29（3）：159-160.
[5] 姚星,刘爱萍,钱永刚,等. 糖尿病患病危险因素及干预措施的研究进展[J]. 医学综述,2014,20（9）：1616- 1618.
[6] 云佩佩,史丽萍,李秋云,等. 糖尿病危险因素的研究进展[J]. 中国综合临床,2014,30（13）：140-142.
[7] 何耀. 我国超重/肥胖流行趋势及其对公共卫生的挑战[J]. 中华流行病学杂志,2014,35（4）：345-348.
[8] 李强.肥胖促进2型糖尿病发生的研究进展[J]. 临床内科杂志,2012,29（3）：152-154.
[9] SHIELDS M,TREMBLAY M S,CONNOR G S,et al. Abdominal obesity and cardiovascular disease risk factors within body mass index categories[J]. Health Rep,2012,23（2）：7-15.
[10] 苗蕾. 炎症因子及脂肪因子与高尿酸血症的关系及民族异质性研究[D]. 乌鲁木齐：新疆医科大学,2012.
[11] 邱吉凤,付淑珍,赵丽珍,等.山区儿童胰岛素抵抗及相关因素分析[J]. 浙江预防医学,2015,27（4）：334-336,345.
[12] 朱海清,杨兆军,张波,等. 中国正常糖耐量人群胰岛功能及胰岛素敏感性随增龄的变化[J]. 中华医学杂志,2012,92（28）：1948-1953.
[13] 晁爱军,朱珊,胡玮,等. 不同性别体重指数与身体成份构成及脂肪分布的关系[J].中华骨质疏松和骨矿盐疾病杂志,2009,2（1）：24-27.
[14] 罗胜兰,方乐,叶真,等. 糖尿病患者危险因素性别差异[J]. 浙江预防医学,2013,25（11）：1-3,15.?
[15] GREGOR M F,HOTAMISLIGIL G S.Inflammatory mechanisms in obesity[J]. Annu Rev Immunol,2011,29（1）：415- 445.
[16] 胡立新. 单纯性肥胖儿童hs-CRP、IL-6水平与胰岛素抵抗指数相关性研究[J]. 医学综述,2014,20（5）：915-916.
[17] AWAZAWA M,UEKI K,INABE K,et al. Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression viaa macrophage-derived IL-6-dependent pathway[J]. Cell Metab,2011,13（4）：401-412.
[18] 刘波,林海,石琳琳,等. 妊娠糖尿病患者血清 CRP 、IL-6水平的变化及其临床意义[J]. 中国实验诊断学,2010,6（14）：899-901.
[19] PRADHAN A D,MANSON J E,RIFAI N,et al. C-reactive protein,interleukin 6,and risk of developing type 2 diabetes mellitus[J]. JAMA,2001,286（3）：327-334. |
|
|
|
