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| Effects of cassia seed,red yeast rice,ginkgo biloba leaf and salvia miltiorrhiza compounds on blood lipid level of rats |
| LIU Mei-tong, CUI Lu-wei, LI Zi-min, HU Yu-ming
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| Hunan Provincial Center for Disease Control and Prevention,Changsha,Hunan 410005,China |
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Abstract Objective To learn the effects of cassia seed extract,ginkgo biloba leaf extract,salvia miltiorrhiza extract and red yeast rice compounds on blood lipid level of rats with hyperlipidemia. Methods The model of hyperlipidemia in SD rats was established. The rats in the low,moderate and high dose groups were given 0.267 g/kg body weight,0.533 g/kg body weight and 1.600 g/kg body weight of cassia seed,red yeast rice,ginkgo biloba leaf and salvia miltiorrhiza compounds by gavage for 30 days. A blank control group and a model control group were also set. The levels of serum total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）and low-density lipoprotein cholesterol（LDL-C）in the five groups were measured before and after the intragastric administration. Results One week after the model was founded,the levels of serum TC,TG and LDL-C in the model control group were higher than those in the blank control group（P<0.05）. Before the intragastric administration,there were no significant differences in the levels of serum TC,TG,HDL-C and LDL-C between the model control group and each dosage group（P>0.05）. After the intragastric administration,there were no significant differences in the levels of serum HDL-C and LDL-C between the model control group and each dosage group（P>0.05）. The levels of serum TC and TG in the high dose group were significantly lower than those in the model control group（P<0.05）;There was no significant differences in the levels of serum TC and TG between the moderate dose,low dose group and the model control group（P>0.05）. Conclusion The compounds of cassia seed extract,red yeast rice,ginkgo biloba extract and salvia miltiorrhiza extract with a dosage of 1.600 g/kg body weight can reduce serum TC and TG levels in rats with hyperlipidemia.
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Received: 20 July 2018
Revised: 29 September 2018
Published: 18 January 2019
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