|
|
Epidemiological characteristics of hepatitis A before and after expanded immunization program in Huzhou |
LUO Xiao-fu*, JIN Ming-juan, ZHANG Chao
|
*Medicine college of Zhejiang University,Hangzhou,Zhejiang 310012,China |
|
|
Abstract Objective To compare the epidemiological characteristics of hepatitis A before and after the inclusion of hepatitis A vaccine in expanded program on immunization(EPI)in Huzhou.Methods The data of hepatitis A cases,immunization of hepatitis A vaccine from 1998 to 2017 in Huzhou were collected, epidemic strength,time,population and the effect of hepatitis A vaccine inoculation on the epidemic of hepatitis A was analyzed.Results A total of 3 194 hepatitis A cases were reported in Huzhou from 1998 to 2017. The average annual incidence of hepatitis A was 5.76/100 000,which was tended to decrease(P<0.05). The annual incidence rate decreased from 10.23/100 000 before EPI to 1.72/100 000 after EPI(P<0.05). The incidence rate among male(13.31/100 000)was higher than that among female(7.04/100 000)before EPI(P<0.05). There was no significant difference between incidence rate among male(1.94/100 000)and female(1.50/100 000)after EPI(P>0.05). The incidence of hepatitis A after EPI in all age groups was lower than that before EPI(P<0.05). There was no case report in children less than 15 years old after the year 2015. The coverage rate of hepatitis A vaccine increased from 9.09% to 99.25% among children aged 18-24 months after EPI. The incidence of hepatitis A was negatively correlated with vaccination rate among children aged 0-14 years(rs=-0.807,P<0.05).Conclusion After the hepatitis A vaccine was included in the EPI in Huzhou,the vaccination rate increased,the incidence of hepatitis A decreased,and the gender gap narrowed.
|
Received: 21 May 2018
Revised: 26 July 2018
Published: 06 November 2018
|
|
|
|
|
[1] 海田,梁晓峰,殷大鹏,等. 中国1990—2006年甲型病毒性肝炎流行病学特征分析[J]. 中国计划免疫,2007,13(5):466-469. [2] 郑徽,卢永,王富珍,等. 中国2004—2006年甲型病毒性肝炎疫情分析[J]. 中国计划免疫,2007,13(4):336-340. [3] 刘燕敏,陈园生,崔富强,等. 中国2004—2009年甲型病毒性肝炎流行病学特征分析[M]. 中国疫苗和免疫,2010,16(5):453-456. [4] 孙校金,王富珍,郑徽,等. 2004—2015年中国甲型病毒性肝炎流行病学特征分析[J]. 中华预防医学杂志,2017,51(12):1091-1096. [5] 徐也晴,催富强,张国民,等. 中国2007—2011年甲型和戊型病毒性肝炎以及细菌性痢疾流行病学特征分析[J]. 中国疫苗和免疫,2013,19(6):501-505. [6] 金玫华,沈建勇,韩建康,等. 1995—2006年浙江省湖州市甲型病毒性肝炎流行特征分析[J]. 疾病监测,2008,23(9):542-544. [7] 沈建勇,金玫华,朱新凤,等. 湖州市甲型、戊型病毒性肝炎流行特征分析[J]. 海峡预防医学,2007,13(6):40-41. [8] 沈建勇,韩建康,金玫华,等. 湖州市自然人群甲型及戊型肝炎IgG抗体平行检测结果分析[J]. 疾病监测,2007,22(12):809-811. [9] 姜文国,牛香莲. 甲型肝炎减毒活疫苗应急接种效果观察[J]. 现代预防医学,2001,28(1):59,61. [10] 凡娅,刘颜,刘友全,等. 地震灾区甲肝疫苗群体应急接种后免疫效果分析[J]. 现代预防医学,2013,40(4):662-671. [11] 秦莎莎,廖贵蓉,裴小琴,等. 我国甲肝免疫水平现状分析-基于多水平Meta 分析结果[J]. 现代预防医学,2010,37(6):1020-1022. [12] 商庆龙,张国名,腾旭,等. 甲型肝炎疫苗的应用和接种效果评价[J].中国疫苗和免疫,2012,18(3):268-271. [13] 王慎玉,甘正凯,邓璇,等. 浙江省甲型病毒性肝炎流行病学特征分析[J]. 预防医学,2016,28(12):1253-1256. [14] 蒋征刚,李倩,陈恩富,等. 浙江省甲型病毒性肝炎流行趋势[J]. 浙江预防医学,2012,24(8):21-23. [15] 蓝岳云,姜宪尘. 免疫接种对衢州市甲型肝炎流行特征的影响[J]. 浙江预防医学,2015,27(12):1230-1232. [16] 马涛,谭兆营,朱立国,等.2005—2014年江苏省甲型病毒性肝炎流行病学特征[J].职业与健康,2015,31(24):3443- 3445,3450. [17] 解晓华,单爱兰,夏卫东. 1996—2005年天津市甲型病毒性肝炎流行特征分析[J].疾病监测,2007,22(2):85-103. [18] 车鑫仁,孙昼,许二萍,等. 杭州市2004—2013年甲型和戊型肝炎流行病学特征分析[J].中华流行病学杂志,2015,36(4):409-410. [19] 杨汶桢,宋沈超,石作宏,等. 贵阳市1993—2012年甲型病毒性肝炎流行特征与防控策略分析[J].贵州医药,2015,39(9):852-853. [20] 董蒲梅,郭万申,范军星,等. 河南省1991年至2010年甲型病毒性肝炎流行病学特征[J].郑州大学学报(医学版),2012,47(1):94-97. |
|
|
|