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| Association between glucose and lipid metabolism during the second trimester and pregnancy outcomes |
| WANG Li-jun*，GAN Pei-yuan，HE Li-ya，LU Yi，HE Wen-fang，XU Ze-ru，GUO Jun-ping ，HUA Yan-yin
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| *Zhejiang Provincial People's Hospital，People's Hospital of Hangzhou Medical College，Hangzhou，Zhejiang 310014，China |
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Abstract Objective To analyze the association between glucose and lipid metabolism during the second trimester and pregnancy outcomes.Methods A total of 268 pregnant women who underwent prenatal examination and baby delivering at Zhejiang Provincial People's Hospital during June 2014 to may 2017 were recuited. 110 of those subjects were diagnosed with gestational diabetes mellitus（GMD）. The level of fasting blood glucose（FBG），total cholesterol （TC），triglyceride （TG），high-density lipoprotein （HDL-C），low-density lipoprotein cholesterol （LDL-C），uric acid （UA） and other metabolism indexes were measured during the second trimester. Data including demographic features，pregnancy complications and pregnancy outcomes were also collected. Logistic regression model was applied to analyze the association between glucose and lipid metabolism during the second trimester and pregnancy outcomes.Results Age and the levels of FBG，TC，TG，LDL-C and UA in GDM group were significantly higher than the normal glucose tolerance（NGT） group，while the level of HDL-C were significantly lower（P<0.05）. The incidence of cesarean section，macrosomia and premature were higher in GDM group than that in NGT group（P<0.05）. The rise of age（OR=1.068，95%CI：1.006-1.133） and the levels of TG（OR=2.078，95%CI：1.157-3.731），LDL-C（OR=2.047，95%CI：1.179-3.552），UA（OR=9.165，95%CI：1.964-45.056）and FBG（OR=17.384， 95%CI：2.098-144.026） would increase the risk of GMD，while the increase of HDL-C（OR=0.370，95%CI：0.015-0.944） had opposite effect. Pregnant women with advanced age were more likely to go through cesarean section（OR=1.073，95%CI：1.015-1.134）. TC level （OR=2.939，95%CI：1.128-7.659）and macrosomia had a positive correlation. Age（OR=1.132， 95%CI：1.005-1.274）and LDL-C level（OR=3.512，95%CI：1.033-11.937）were positively related with premature.Conclusion The disorder of glucose and lipid metabolism during the second trimester may affect the pregnancy outcomes.
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Published: 25 July 2018
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