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| Atmospheric PM2.5 exposure on semen quality in adult men in Taizhou |
| HU Fu-yu*, GUO Ting-ting, ZHU Shan-shan, HUA Jing, LIU Yi-ping, ZHANG Li-ming, YANG Ying-ying
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| *Taizhou Central Hospital,Taizhou,Zhejiang 318000,China |
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Abstract Objective To explore the effects of ambient fine particulate matter（PM2.5）exposure on semen quality in healthy adult men .Methods The semen quality data were collected from the pre-pregnancy check outpatient of Taizhou Central Hospital from August 2014 to December 2017,excluding the patients with any disease of reproductive system. The data of daily pollutant concentration of this area during the same period were also collected to estimate the exposures of PM2.5,PM10,SO2,NO2,O3 and CO during 90 days before each semen examination. Logistic regression model was applied to estimate the association between PM2.5 exposure and semen quality .Results A total of 3 456 healthy adult men were included in this study. The median （interquartile range）of the total sperm count of the 3 456 subjects was 161.00（122.00）×106,and 94.40% of the subjects could reach the lower reference limit for sperm count. The median（interquartile range）of the sperm concentration was 22.20（18.80）×106/mL,and 69.50% of the subjects were qualified. The median（interquartile range）of the sperm vitality was 55.30%（23.37%）,and 44.10% of the subjects were qualified. The median（interquartile range）of daily average concentration of PM2.5 at 0-90 days before semen examination was 37.82（12.33）μg/m3. The results of multivariate logistic regression model showed that,with each 12.33 μg/m3 increase of PM2.5 exposures at 0-90 days before semen examination,the odds ratios of unqualified sperm concentration,sperm motility and sperm vitality were 1.236（95%CI：1.041-1.466）,1.493（95%CI：1.260-1.770）and 1.462（95%CI：1.246-1.715）,respectively .Conclusion The results suggested that high concentration of ambient PM2.5 exposure during the sperm development period negatively affects sperm concentration,sperm motility and sperm vitality.
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Received: 01 August 2018
Revised: 23 October 2018
Published: 03 January 2019
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[1] PETRAGLIA F,SEROUR G I,CHAPRON C.The changing prevalence of infertility[J]. Int J Gynaecol Obstet,2013,123(S2):S4-S8.
[2] VANDER BORGHT M,WYNS C. Fertility and infertility:definition and epidemiology[J/OL]. Clin Biochem,(2018-03-16)[2018- 08-01]. http://www.sciencedirect.com/science/article/pii/S000991 2018302200.DOI:10.1016/j.clinbiochem.2018.03.012.
[3] 江元元,徐望明. 影响男性精液质量的因素分析[J]. 中国生育健康杂志,2018,29(2):178-182.
[4] CARLSEN E,GIWERCMAN A,KEIDING N,et al.Evidence for decreasing quality of semen during past 50 years[J]. BMJ,1992,305(6854):609-613.
[5] SENGUPTA P,NWAGHA U,DUTTA S,et al.Evidence for decreasing sperm count in African population from 1965 to 2015[J]. Afr Health Sci,2017,17(2):418-427.
[6] ZHOU N,JIANG C,CHEN Q,et al.Exposures to atmospheric PM10 and PM10-2.5 affect male semen quality:results of MARHCS Study[J]. Environ Sci Technol,2018,52(3):1571-1581.
[7] CARRE J,GATIMEL N,MOREAU J,et al.Does air pollution play a role in infertility?:a systematic review[J]. Environ Health,2017,16(1):82.
[8] DENG Z,CHEN F,ZHANG M,et al.Association between air pollution and sperm quality:a systematic review and meta-analysis[J]. Environ Pollut,2016,208(Pt B):663-669.
[9] HANSEN C,LUBEN T J,SACKS J D,et al.The effect of ambient air pollution on sperm quality[J]. Environ Health Perspect,2010,118(2):203-209.
[10] 谷翊群,陈振文,卢文红. 世界卫生组织人类精液检查与处理实验室手册[M]. 5版. 北京:人民卫生出版社,2011.
[11] PATEL A S,LEONG J Y,RAMASAMY R.Prediction of male infertility by the World Health Organization laboratory manual for assessment of semen analysis:a systematic review[J]. Arab J Urol,2018,16(1):96-102.
[12] WU L,JIN L,SHI T M,et al.Association between ambient particulate matter exposure and semen quality in Wuhan,China[J]. Environ Int,2017,98:219-228.
[13] RADWAN M,JUREWICS J,POLANSKA K,et al.Exposure to ambient air pollution—does it affect semen quality and the level of reproductive hormones?[J]. Ann Hum Biol,2016,43(1):50-56.
[14] SANTI D,VEZZANI S,GRANATA A R,et al.Sperm quality and environment:a retrospective,cohort study in a Northern province of Italy[J]. Environ Res,2016,150:144-153.
[15] HAMMOUD A,CARRELL D T,GIBSON M,et al.Decreased sperm motility is associated with air pollution in Salt Lake City[J]. Fertil Steril,2010,93(6):1875-1879.
[16] CAO X N,YAN C,LIU D Y,et al.Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B(Akt)signaling pathway[J]. Toxicol Lett,2015,237(3):181-190.
[17] 蔡文伟,江楠. 男性不育患者精液活性氧与精子参数的关系研究[J]. 预防医学,2017,29(3):264-265.
[18] 赵凤敏,吴一峰,吴峰. 大气污染物浓度与上呼吸道疾病门诊就诊的关联性研究[J]. 浙江预防医学,2016,28(2):165-167.
[19] 张世鑫,伍立志,陈苘,等. 大气细颗粒物及其水提物对人支气管上皮细胞的氧化损伤效应[J]. 浙江预防医学,2016,28(4):332-335. |
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