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| Drug resistance of tuberculosis patients in Jinhua |
| ZHANG Zi-gen，ZHENG Hao，ZHANG Guang-ming
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| Jinhua Center for Disease Control and Prevention，Jinhua，Zhejiang 321002，China |
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Abstract Objective To understand the drug resistance of pulmonary tuberculosis（TB）patients in Jinhua and provide scientific basis for individualized treatment and the effective control of drug resistant TB. Methods The sputum specimens from TB patients reported in Jinhua TB hospital from July 1，2015 to June 30，2016 were identified. The drug sensitivity test was carried out for the specimens with positive culture and identified as Mycobacterium TB. The drug resistance rate，drug resistance type and drug resistance spectrum of the patients were analyzed. Results A total of 939 strains were obtained，and 869 strains were identified as Mycobacterium TB，accounting for 92.55%. Among the 869 TB patients，there were 168 cases of drug resistance，and the total resistance rate was 19.33%. The highest proportion of resistance spectrum was streptomycin（4.60%），and the lowest was ethambutol（0.23%）. Of 869 TB patients，802 cases were first treated and 67 cases were retreated. The total resistance rate，multiple drug resistance rate and single drug resistance rate of the retreated patients were 58.21%，29.85% and 25.37%，which were higher than 16.08%，3.24% and 10.22% of the first treated patients （P<0.05）. The drug resistance spectrum of the first treated patients was streptomycin（4.36%），isoniazide（3.24%）and ofloxacin（1.62%）. The drug resistance spectrum of the retreated patients was rifampicin + isaziazide（14.93%），isoniazide（11.94%），streptomycin（7.46%），rifampicin + isaziazide + amethybutanol + streptomycin（5.97%）and ofloxacin（4.48%）. Conclusion The total resistance rate of TB patients in Jinhua was 19.33%，and drug resistance in retreated patients was more severe than that in first treated patients.
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Published: 04 September 2018
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[1] 杜娟，严重耐多药结核病的流行现状、防控难点及对策[J] .医学研究杂志，2010，39（8）：17-21.
[2] WU B，ZHANG L，LIU Z，et al. Drug-resistant tuberculosis in Zhejiang Province，China：an updated analysis of time trends，1999-2013[J] . Glob Health Action，2017，10（1）：e1293925.
[3] 中国防痨协会基础专业委员会. 结核病诊断实验室检验规程[M] . 北京：中国教育文化出版社，2006：13-56.
[4] 李清春，吴敏，陆敏，等. 浙江省杭州市肺结核患者耐药监测结果分析[J] . 疾病监测，2014，29（3）：210-214.
[5] 全国第五次结核病流行病学抽样技术指导组. 2010年全国第五次结核病流行病学抽样调查报告[J] . 中国防痨杂志，2012，34（8）：485-508.
[6] 陈松华，吴蓓蓓，柳正卫，等. 浙江省结核病耐药状况分析[J] . 预防医学，2016，28（8）：757-761.
[7] COHEN T，MURRAY M. Incident tuberculosis among recent US immigrants and exogenous reinfection[J] . Emerg Infect Dis，2005， 11（5）：725-728.
[8] 于梅，车洋，平国华，等. 2007年至2010年宁波市结核病耐药趋势及影响因素[J] . 中华传染病杂志，2012，30（1）：48-52.
[9] LIU Q，ZHU LM，SHAO Y，et al. Rates and risk factor for drug resistence tuberculosis in northeastern China[J] . BMC Public Health，2013，13：1171.
[10] ALENA S，HENADZ H，AKSANA Z，et al. Multidrug- resistenttuberculosis in Belarus：the size of the problem and associated risk factor[J] . Bull World Organ，2013，91：36-45.
[11] 朱建福，王伟炳，王学才，等. 德清县耐药肺结核流行情况及危险因素研究[J] . 浙江预防医学，2009，21（9）：6-8.
[12] 梅建，沈鑫，沈梅，等. 上海市结核分枝杆菌耐药性监测研究报告[J] . 中国防痨杂志，2007，29（5）：395-397.
[13] 潘稚芬，高跃中，刘加良，等. 嘉兴市耐多药肺结核筛查结果分析[J] . 预防医学，2016，28（8）：821-824.
[14] 王，石小俊，张幼萍，等. 114株结核分枝杆菌耐药性分析[J] . 预防医学，2016，28（11）：1131-1132，1135.
[15] World Health Organization. Guidelines for the programmatic management of drug-resistant tuberculosis[M] . Geneva：World Health Organization，2011.
[16] 车洋，于梅，平国华，等. 宁波地区2010—2011年结核病耐药监测结果及影响因素分析[J] . 中国卫生检验杂志，2013，23（2）：495-497.
[17] 王敏，郝晓刚，郑夏雯.衢州市2010—2013年涂阳肺结核耐药状况分析[J] .浙江预防医学，2014，26（1）：61-63. |
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