抑制素A、激活素A与子宫动脉搏动指数联合预测子痫前期的效果分析

doi:10.19485/j.cnki.issn1007-0931.2017.03.009

Preventive Medicine

2017, Vol. 29

Issue (3): 251-254,259 DOI: 10.19485/j.cnki.issn1007-0931.2017.03.009

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An analysis on inhibin A and activin A combined with uterine artery doppler in the prediction of preeclampsia

LI Li-jie,WANG Liang-ping,ZHENG Yan-mei

Departments of Endocrinology,Zhejiang Provincial People's Hospital,Hangzhou,Zhejiang,310014,China

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Abstract Objective To evaluate the predictive value of pre-eclampsia with the combination of inhibin A,activin A and uterine artery doppler.Methods The single pregnant pregnant women were divided into 9-12 week of pregnancy groups and 13-16 week of gestation group based on examination of gestational age.According to the outcome of further follow-up the women are divided into normal pregnancy (9-12 week pregnant or 13-16 week pregnant normal group) and the PE group (9-12 weeks pregnant or pregnant 13-16 PE group).Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentration of inhibin A and activin A.Doppler ultrasound were used to examine UAPI.The results were converted to MoM values to calculate the combined detection specificity and sensitivity.Results The concentration of serum inhibin A and activin A and UAPI in 9-12 week pregnant PE group were significantly higher than that in 9-12 week normal pregnant (P<0.05).The concentration of serum inhibin A and activin A and UAPI in 13-16 week pregnant PE group were significantly higher than that in 13-16 week normal pregnant (P<0.05).When the maximum area under the curve of three indicator combined application (AUC=0.836) in 9-12 week pregnant,the specificity was 72% and the sensitivity was 83%.When the maximum area under the curve of three indicators combined application (AUC=0.912) in 13-16 week pregnant,the specificity was 87% and the sensitivity was 86%.Conclusion The combined application of peripheral blood inhibin A,activin A and UAPI could predict PE.The combined application of indicator detection index provides a high degree of specificity,sensitivity and predictive value in 13-16 week pregnant.

Key words： Pre-eclampsia;Inhibin A;Activin A Uterine artery pulsation index

Published: 21 November 2017

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R714.244

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	LI Li-jie
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LI Li-jie,WANG Liang-ping,ZHENG Yan-mei. An analysis on inhibin A and activin A combined with uterine artery doppler in the prediction of preeclampsia[J]. Preventive Medicine, 2017, 29(3): 251-254,259.

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http://www.zjyfyxzz.com/EN/10.19485/j.cnki.issn1007-0931.2017.03.009 OR http://www.zjyfyxzz.com/EN/Y2017/V29/I3/251

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