Abstract：Objective To observe the effects of physical fitness intervention on blood glucose regulation in community residents with pre-diabetes. Methods We selected some subjects between 25-69 years old with diagnosis of prediabetes in community of Hangzhou and divided them into the experimental group（73 cases）and the control group（20 cases）. The control group received health education and family self-exercise;while the experimental group further received personalized programs of physical fitness intervention for 12 weeks in each person,including aerobic gymnastics,lastic band resistance training and flexibility training. We collected blood samples from the two groups to detect the level of blood glucose,the level of the serum insulin,and to calculate the insulin resistance index after 4,8,12 weeks' intervention. Results Totally 78 cases including 61 cases of the experimental group and 17 cases of the control group finished the research. After 12 weeks,the levels of FPG in the experimental group and the control group were respectively（5.14±0.76）and（5.66±1.01）mmol/L;the levels of OGTT-2 h PG in the experimental group and the control group were respectively（6.45±1.29）and（7.98±1.12）mmol/L;the levels of serum insulin in the experimental group and the control group were respectively（17.73±2.44）and（32.55±8.05）μIU/mL;the levels of insulin resistance index in the experimental group and the control group were respectively 2.35±0.96 and 3.21±1.16. Generalized estimation equation analysis showed that the levels of FPG,OGTT-2 h PG,serum insulin and insulin resistance index declined more in the experimental group than in the control group（all P<0.05）. Conclusion Physical fitness training can effectively regulate the levels of blood glucose and insulin sensitivity,and improve the insulin resistance metabolism.
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