Abstract：Objective To evaluate the association of cervical cancer and the G/C single nucleotide polymorphism at codon 72 in p53 gene exon-4 in Chinese population.Methods Literatures were searched in CNKI, VIP, CBM, PubMed, EMBase, the Cochrane Library (Issue 1, 2015), WanFang Data Database (1980—2015) with computer.Results Thirteen studies involving 1 780 cervical cancer patients and 1 517 healthy volunteers were included. According to the situation of the HPV infection in research object, thirteen studies were divided into two subgroups. The results of meta-analyses in the subgroup of non-HPV infection showed that the Chinese women having the genotype G/G presented no increased relative risk compared to that with the genotype C/C(OR=0.980, 95%CI: 0.558-1.723).The allele G showed no increased relative risk compared to the allele C (OR=1.070, 95%CI: 0.789-1.449) The results of meta-analyses in the subgroup of HPV infection showed that the Chinese women having the genotype G/G presented no increased relative risk compared to that with the genotype C/C(OR=0.891, 95%CI: 0.213-3.722).The allele G showed no increased relative risk compared to the allele C (OR=0.981, 95%CI: 0.493-1.951).Conclusion This meta-analysis demonstrates that G/C single nucleotide polymorphism at codon 72 in p53 gene exon-4 were not associated with cervical cancer in Chinese women.
喻芳明,叶滕,苏杨娜,毛广运,施小柯,张本龙. p53基因第4外显子第72密码子多态性与中国女性宫颈癌相关性的Meta分析[J]. 预防医学, 2016, 28(8): 770-775.
YU Fang-ming,YE Teng,SU Yang-na,MAO Guang-yun,SHI Xiao-ke,ZHANG Ben-long. A meta-analysis on the association of the codon 72 polymorphism in p53 gene with the cervical cancer in Chinese population. Preventive Medicine, 2016, 28(8): 770-775.
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