A study on the association among serum insulin, IGFBP3, and endometrial cancer risk in Chinese women
HUANG Jia-min1, ZHANG Yan1, LV Shi-ming1, WANG Qing-qing2
1Department of Clinical Laboratory, the Affiliated Women's Hospital, School of Medicine, Zhejiang University,Hangzhou 310006, China; 2Zhejiang University Institute of Immunology, Hangzhou 310058, China
Abstract：ObjectiveTo explore the association among serum insulin, IGFBP3, and endometrial cancer risk in Chinese women. MethodsSerum insulin and IGFBP3 were detected by ELISA method in 206 patients with endometrial carcinoma and 310 healthy women. Using logistic regression analysis after adjustments for BMI, serum glucose and triglycerides to explore the association among the two indicators and the risk of endometrial carcinoma. ResultsIncreased insulin were found in the women with endometrial carcinomas as compared with that of controls [Mean±SD:insulin (14.84±16.72) uU·mL-1 in women with cancer versus (8.13±9.40) uU·mL-1 in controls, P<0.01]. However, serum IGFBP3 was not significantly higher in women with endometrial cancer [Mean±SD:IGFBP3 (1.76±2.44) mg·L-1 in women with cancer versus (1.57±1.80) mg·L-1in controls, P>0.05]. The risk for endometrial cancer was significantly higher in the upper quartile relevant to the lowest quartile of serum insulin, and lower in the upper quartile of serum IGFBP3 (P<0.05). Logistic regression analysis showed that serum insulin was the risk factor of endometrial carcinoma(OR=2.34, 95%CI:1.32-4.14), after adjusting obesity/overweight status, serum glucose, total cholesterol, total glyceride, and HDL-C. ConclusionHyperinsulinemia was an independent risk factor for endometrial carcinomas in Chinese women. However, the protective role of increased serum IGFBP3 should be validated further.
黄佳敏, 张艳, 吕时铭, 王青青. 血清胰岛素和IGFBP3水平与子宫内膜癌相关性研究[J]. 预防医学, 2016, 28(4): 358-361.
HUANG Jia-min, ZHANG Yan, LV Shi-ming, WANG Qing-qing. A study on the association among serum insulin, IGFBP3, and endometrial cancer risk in Chinese women. Preventive Medicine, 2016, 28(4): 358-361.
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