Abstract：ObjectiveTo investigate an imported case of Zika virus disease in Wenzhou City, to explore the source of infection,to analyse the problems during surveillance and diagnosis, and to provide evidence for prevention and control of Zika virus disease. MethodsBy field investigation, medical records of the patient were collected and a face-to-face interview was conducted; blood, urine and saliva samples within 48 h were collected for RNA detection; assess the risk of disease spreading by mosquito surveillance and take control measures. ResultsThe onset of the disease was on the patient's way home from aboard on February 21st,2016.Before then, She lived in Paramaribo, the capital of Suriname in South America, which is an epidemic area of Zika virus.The patient had exposure history,with red,diffuse rash on her head,face,neck and limbs,and once was diagnosed as allergic eruption because of no fever. The two blood samples were both tested negative yet We detected urine and saliva samples showed positive. With the evidence above, the patient was finally diagnosed as an imported Zika virus case. The spreading risk of this case was low due to the low temperature. Conclusionthere may be cases without fever or with blood sample tested RNA negative. As the weather gets warmer, missed diagnosis should be aware of, or the risk of spreading through mosquitos would increase. Therefore, in order to further improvement should lie in mosquito control and disease surveillance.
[1] DICK G W, KITCHEN S F, HADDOW A J. Zika Virus (I). Isolations and serological specificity[J]. Trans R Soc Trop Med Hyg, 1952, 46(5):509-520. [2] EUROPEAN CENTRE FOR DISEASE PREVENTION ANDCONTROL. Zika virus infection outbreak, Brazil and the Pacific region: ECDC; 2014 [updated 2015 May 26]. Available from: http://ecdc.europa.eu/en/publications/Publications/rapid- risk-assessment-Zika%20virus-south-america-Brazil-2015.pdf [3] Centers for disease control and prevention. Zika Virus. http://www.cdc.gov/zika. [4] WHO. Zika virus. http://www.who.int/mediacentre/factsheets/zika/en/. [5] MACNAMARA F N. Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria[J]. Trans R Soc Trop Med Hyg,1954,48(2):139-144. [6] OLSON J G, KSIAZEK T G. Zika virus, a cause of fever in Central Java, Indonesia[J]. Trans R Soc Trop Med Hyg,1981,75(3):389-393. [7] DUFFY M R, CHEN T H, HANCOCK W T, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia[J]. N Engl J Med,2009,360(24):2536-2543. [8] BUATHONG R, HERMANN L, THAISOMBOONSUK B, et al. Detection of Zika Virus Infection in Thailand, 2012- 2014[J]. Am J Trop Med Hyg, 2015,93(2):380-383. [9] ALERA M T, HERMANN L, TAC-AN I A,et al. Zika virus infection, Philippines, 2012[J]. Emerg Infect Dis, 2015,21(4):722-724. [10] BARANTI C, PIORKOWSKI G, CHARREL RN, et al. Complete coding sequence of Zika virus from a French Polynesia outbreak in 2013[J]. Genome Announc 2014, 2:e00500 514. http://dx.doi.org/10.1128/geno-meA. 00500-14. [11] OUMAR FAYE, OUSMANE FAYE, ANNE DUPRESSOIR, et al. One-step RT-PCR for detection of Zika virus[J].Journal of clinical Virology,2008, 43(1):96-101. [12] GAUTRET P, SIMON G. Dengue, chikungunya and Zika and mass gatherings: What happened in Brazil, 2014[J]. Travel Med Infect Dis 2015 Dec 24. pii: S1477- 8939(15)00205-7. [13] MUSSO D, CAO-LORMEAU V M, GUBLER D J. Zika virus: following the path of dengue and chikungunya [J]. Lancet,2015,386(9990):243-244. [14] MARCONDES C B, XIMENES M F. Zika virus in Brazil and the danger of infestation by Aedes (Stegomyia) mosquitoes [J]. Rev Soc Bras Med Trop 2015 Dec 22. pii: S0037- 86822015005003102. [Epub ahead of print]. [15] HAYES E B. Zika virus outside Africa[J]. Emerging Infectious Diseases,2009(9),15: 1347-1350. [16] 杨天赐,傅桂明.浙江省登革热传播媒介白纹伊蚊调查研究[J].中华卫生杀虫药械,2006,12(3):189-191. [17] 龚震宇,傅桂明,杨天赐,等.浙江省病媒生物监测和群落动态研究[J].疾病监测,2010,25(4):294-298.
