摘要目的 了解2018年浙江省衢州市居民麻疹抗体水平,为完善麻疹防控策略提供依据。方法 随机抽取衢州市柯城区和常山县10个乡镇（街道）的0~59岁常住居民进行调查,收集居民人口学和含麻疹成分疫苗（MCV）接种资料,采集血清并采用酶联免疫吸附试验检测麻疹IgG抗体,分析居民麻疹抗体阳性率、保护率和几何平均浓度（GMC）。结果 调查606人,男女性别比为0.83∶1。年龄M（QR）为17.36（29.07）岁。有MCV接种史399人,占65.84%。麻疹IgG抗体阳性率为94.88%,保护率为48.68%,GMC为784.51（95%CI：731.14~841.40）mIU/mL。男性麻疹IgG抗体阳性率高于女性（97.08% vs. 93.07%,χ2=4.968,P=0.026）,保护率低于女性（44.16% vs. 52.41%,χ2=4.089,P=0.043）。居民麻疹IgG抗体保护率和GMC随年龄增长呈“U”型分布,10~<40岁居民的保护率较低,为23.53%~46.67%,GMC均未达到保护性水平。有明确2剂次MCV接种史≤15岁居民233人,末剂MCV接种后<1~11年,麻疹IgG抗体阳性率（χ2趋势=7.260,P=0.007）、保护率（χ2趋势=12.756,P<0.001）和GMC（rs=-0.289,P<0.001）随时间延长呈下降趋势。结论 2018年衢州市居民麻疹抗体阳性率较高,但10~<40岁居民保护率偏低,建议提高该年龄段人群强化免疫覆盖。
Abstract：Objective To investigate the measles antibody level among residents in Quzhou City, Zhejiang Province in 2018, so as to provide the evidence for improving the measles control strategy. Methods The permanent residents aged 0 to 59 years were randomly sampled from 10 townships ( streets ) in Kecheng District and Changshan County of Quzhou City. Residents' demographics and vaccination of measles-containing vaccine ( MCV ) were collected, and serum anti- measles IgG antibody was detected using enzyme-linked immunosorbent assay ( ELISA ). The positive rate, protective rate and geometric mean concentration (GMC) of anti-measles antibody were estimated. Results A total of 606 residents were tested, with a male to female ratio of 0.83∶1. The subjects had a median age ( interquartile range ) of 17.36 ( 29.07 ) years, and 399 residents ( 65.84% ) had a vaccination history of MCV. The positive rate, protective rate and GMC of anti-measles IgG antibody were 94.88%, 48.68%, and 784.51 ( 95%CI: 731.14-841.40) mIU/mL, respectively. The positive rate of anti-measles IgG antibody was higher in men than in women ( 97.08% vs. 93.07%, χ2=4.968, P=0.026 ), and the protection rate was lower in men than in women ( 44.16% vs. 52.41%, χ2=4.089, P=0.043 ). The protective rate and GMC of anti-measles IgG antibody showed a“U”-shaped distribution with age, and a low protective rate was seen in residents aged 10 to 39 years ( 23.53% to 46.67% ), which the GMC of anti-measles IgG antibody that did not reach the protective level. A total of 233 residents at age of 15 years and below had with a history of two-dose MCV vaccination, and the positive rate ( χ2trend=7.260, P=0.007 ), protective rate ( χ2trend=12.756, P<0.001 ) and GMC ( rs=-0.289, P<0.001 ) of anti-measles IgG antibody presented a tendency towards a reduction with time <1 to 11 years after vaccination of the last dose of MCV. Conclusions A high positive rate of anti-measles antibody was detected among residents in Quzhou City in 2018; however, the protection rate of anti-measles antibody was low among residents at ages of 10 to 39 years. The coverage of MCV vaccination is recommended to be improved among residents at ages of 10 to 39 years in Quzhou City.
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