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预防医学  2017, Vol. 29 Issue (5): 464-467    DOI: 10.19485/j.cnki.issn1007-0931.2017.05.008
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温州市7岁以下儿童麻疹发病及影响因素研究
李万仓, 魏晶娇, 王志刚, 郑晓春, 陈玲萍, 孙肖瑜
温州市疾病预防控制中心免疫规划所,浙江 温州 325001
A study on epidemiological characteristic of measles in Wenzhou among children younger than 7 years
LI Wan- cang, WEI Jing-jiao, WANG Zhi-gang, ZHENG Xiao-chun, CHEN Ling-ping, SUN Xiao-yu
The Center for Disease Control and Prevention of Wenzhou City,Wenzhou,325001,Zhejiang,China
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摘要 目的 分析温州市7岁以下儿童麻疹流行特征及影响因素,为控制麻疹提供依据。方法 以温州市2013—2015年麻疹监测信息系统报告的7岁以下儿童麻疹确诊病例为病例组,报告的麻疹排除病例为对照组,对麻疹发病强度、性别、户籍地、所在地发病水平、居住时间、医院暴露史、麻疹免疫史等流行病学特征进行描述,采用Logistic回归模型分析麻疹患病的危险因素。结果 2013—2015年温州市共报告7岁以下儿童麻疹确诊198例,占麻疹报告病例总数的67.58%,年均发病率为8.85/l0万;6~8月龄高发,发病率最高为151.66/10万;流动儿童发病率为15.01/10万,高于本地儿童的5.06/10万(P<0.05)。单因素分析显示,年龄、户籍、居住时间、MCV免疫史等与麻疹发病有关。多因素Logistic回归分析显示,流动儿童(OR=2.28,95%CI:1.56~3.33)、无MCV免疫史(OR=3.83,95%CI:2.48~5.92)和有医院暴露史(OR=2.35,95%CI:1.58~3.47)是麻疹发病的危险因素。结论 温州市7岁以下儿童中6~8月龄麻疹高发,流动儿童、无MCV免疫史和有医院暴露史的儿童麻疹发病风险增加。
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李万仓
魏晶娇
王志刚
郑晓春
陈玲萍
孙肖瑜
关键词 麻疹流行特征儿童影响因素    
AbstractObjective To explore the risk factors for measles among children under 7 years old in Wenzhou,and to provide evidence for establishing scientific strategies on measles elimination. Methods A case-control study was carried out using measles cases(age <7)reported between 2013 to 2015 from the Wenzhou Measles Surveillance System (WZMSS). A sample of 198 cases were generated from the WZMSS confirmed cases of measles,and 371 controls were generated from the WZMSS excluded cases of measles. General characteristics and potential risk factors were collected,such as sex,age,original place of residence,length of stay in Wenzhou,history of hospital exposure and measles immunization history(i.e. receiving measles-containing vaccine) and so on. An univariate and multivariate logistic regression models were used to assess the association between different factors and the incidence of measles ,and to investigate the risk factors that influence the incidence of measles. Results A total of 198 measles cases among children under age 7 were reported between 2013 to 2015 in Wenzhou,taking up 67.58% of the total reported measles cases of WZMSS,and suggesting an average of annual incidence rate of 8.85/10 million. The incidence ratio of male to female was 1.57∶1.00. Children of 6-8 months old had the highest incidence rate of 151.66/10 million. The incidence rate among migrant children was 15.01/10 million and was significantly higher thanlocal children(P<0.05). Univariate logistic regression showed that the incidence of measles were significantly associated with age,original place of residence,length of stay in Wenzhou,history of hospital exposure and measles immunization history(P<0.05). Multivariate logistic regression showed that migrant children(OR =2.28,95%CI: 1.56-3.33),no measles immunization history(OR=3.83,95%CI:2.48-5.92) and having hospital exposure(OR =2.35, 95%CI: 1.58-3.47) were risk factors for the incidence of measles. Conclusion Children of 6-8 months old had the highest incidence rate of measles. Migrant children,nomeasles immunization history and having hospital exposure could increase the incidence rate of measles among children younger than 7.
Key wordsMeasles    Epidemiological characteristics    Childrens    influencing factor.
收稿日期: 2016-09-28      修回日期: 2016-12-26      出版日期: 2017-05-10
中图分类号:  R511.1  
通信作者: 李万仓,E-mail:315554692@qq.com   
作者简介: 李万仓,硕士,副主任医师,主要从事免疫针对性疾病控制工作
引用本文:   
李万仓, 魏晶娇, 王志刚, 郑晓春, 陈玲萍, 孙肖瑜. 温州市7岁以下儿童麻疹发病及影响因素研究[J]. 预防医学, 2017, 29(5): 464-467.
LI Wan- cang, WEI Jing-jiao, WANG Zhi-gang, ZHENG Xiao-chun, CHEN Ling-ping, SUN Xiao-yu. A study on epidemiological characteristic of measles in Wenzhou among children younger than 7 years. Preventive Medicine, 2017, 29(5): 464-467.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn1007-0931.2017.05.008      或      http://www.zjyfyxzz.com/CN/Y2017/V29/I5/464
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