Abstract:Objective To investigate the serum uric acid levels among residents living in Balikun County, Xinjiang Uygur Autonomous Region from 2018 to 2021, so as to provide insights into local hyperuricemia control. Methods The residents at ages of 20 to 69 years undergoing physical examinations in Balikun County Hospital during the period from 2018 to 2021 were enrolled. Their age, gender, and history of medication and disease were collected, and serum uric acid levels were measured. The gender- and age-specific prevalence of hyperuricemia and hypouricemia was descriptively analyzed. Results A total of 3 097 subjects were enrolled, which included 1 210 males ( 39.07% ) and 1 887 females ( 60.93% ) and had a mean age of ( 46.12±12.84 ) years. The overall mean serum uric acid was ( 260.41±71.99 ) μmol/L, and the mean serum uric acid was ( 298.22±69.57 ) μmol/L in men and ( 236.17±62.44 ) μmol/L in women. The serum uric acid level appeared a tendency towards a rise with ages both in whole study subjects and in women ( P<0.05 ). The overall prevalence of hyperuricemia was 4.26%, with 4.63% prevalence in men and 4.03% in women. The prevalence of hyperuricemia appeared a tendency towards a rise with ages both in whole study subjects and in women ( P<0.05 ). The overall prevalence of hypouricemia was 0.71%, with 0.25% prevalence in men and 1.01% in women; the prevalence of moderate hypouricemia was 11.11%, with 2.56% prevalence in men and 16.59% in women. Conclusions Low level of serum uric acid and prevalence of hyperuricemia is detected among residents living in Balikun County. Monitoring of serum uric acid is recommended to be intensified among men.
[1] DEHLIN M,JACOBSSON L,RODDY E,et al.Global epidemiology of gout:prevalence,incidence,treatment patterns and risk factors[J].Nat Rev Rheumatol,2020,16(7):380-390. [2] LIU R,HAN C,WU D,et al.Prevalence of hyperuricemia and gout in mainland China from2000 to 2014:a systematic review and meta-analysis[J/OL].Biomed Res Int,2015(2015-11-10)[2021-12-09].https://doi.org/10.1155/2015/762820. [3] WANG H S,ZHANG H F,SUN L,et al.Roles of hyperuricemia in metabolic syndrome and cardiac-kidney-vascular system diseases[J].Am J Transl Res,2018,10(9):2749-2763. [4] 于宏杰,钟培松,袁红,等.肥胖指标预测高尿酸血症风险研究[J].预防医学,2020,32(8):846-850. YU H J,ZHONG P S,YUAN H,et al.Evaluation of the risk of hyperuricemia by obesity related indicators[J].Prev Med,2020,32(8):846-850. [5] KAWAMURA Y,NAKAYAMA A,SHIMIZU S,et al.A proposal for practical diagnosis of renal hypouricemia:evidenced from genetic studies of nonfunctional variants of URAT1/SLC22A12 among 30 685 Japanese individuals[J/OL].Biomedicines,2021,9(8)(2021-08-13)[2021-12-09].https://doi.org/10.3390/biomedicines9081012. [6] KUSHIYAMA A,NAKATSU Y,MATSUNAGA Y,et al.Role of uric acid metabolism-related inflammation in the pathogenesis of metabolic syndrome components such as atherosclerosis and nonalcoholic steatohepatitis[J/OL].Mediators Inflamm,2016(2016-12-14)[2021-12-09]. https://doi.org/10.1155/2016/8603164. [7] 孙玉萍,张晓进,荣卫,等.哈萨克族受检人群代谢综合征检出率及性别差异的研究[J].国际检验医学杂志,2016,37(10):1305-1307. SUN Y P,ZHANG X J,RONG W,et al.The research of metabolic disease detection rate in Kazakh nation and gender differences[J].Int J Lab Med,2016,37(10):1305-1307. [8] 中华医学会内分泌学分会.中国高尿酸血症与痛风诊疗指南(2019)[J].中华内分泌代谢杂志,2020,36(1):1-13. Chinese Society of Endocrinology,Chinese Medical Association.Guideline for the diagnosis and management of hyperuricemia and gout in China(2019)[J].Chin J Endocrinol Metab,2020,36(1):1-13. [9] NAKAYAMA A,MATSUO H,OHTAHARA A,et al.Clinical practice guideline for renal hypouricemia(1st edition)[J].Hum Cell,2019,32(2):83-87. [10] HUANG X,ZHANG W,TANG W,et al.Prevalence and associated factors of hyperuricemia among urban adults aged 35-79 years in southwestern China:a community-based cross-sectional study[J/OL].Sci Rep,2020,10(1)(2020-09-24)[2021-12-09].https://www.nature.com/articles/s41598-020-72780-3.DOI:10.1038/s41598-020-72780-3. [11] 袁晓敏,朱秀娟,蒋新林,等.巴里坤县汉族和哈萨克族血尿酸水平和高尿酸血症情况调查[J].临床检验杂志,2017,35(4):314-316. YUAN X M,ZHU X J,JIANG X L,et al.Investigation on serum uric acid level and hyperuricemia of Han and Kazak nationality in Balikun County[J].Chin J Clin Lab Sci,2017,35(4):314-316. [12] 雷筱青,杨雪花,李忻.昭苏垦区高原汉族与哈萨克族血尿酸水平及高尿酸血症的情况调查[J].新疆医学,2018,48(3):304-306. LEI X Q,YANG X H,LI X.Investigation of blood uric acid level and hyperuricemia in Han and Kazak Nationalities in Zhaosu Plateau Area[J].Xinjiang Med J,2018,48(3):304-306. [13] CHO S K,WINKLER C A,LEE S J,et al.The prevalence of hyperuricemia sharply increases from the late menopausal transition stage in middle-aged women[J/OL].J Clin Med,2019,8(3)(2019-03-02)[2021-12-09].https://doi.org/10.3390/jcm8030296. [14] 陈艳,尹钰,李旭峰,等.新疆哈萨克族食管癌高发区居民膳食状况及一碳单位代谢相关营养素水平调查[J].中国公共卫生,2017,33(5):780-782. CHEN Y,YIN Y,LI X F,et al.Dietary nutrition and nutrients associated with one carbon unit metabolism among Kazakh people inareas with high esophageal cancer incidence in Xinjiang[J].Chin J Public Health,2017,33(5):780-782. [15] CHOI H K,ATKINSON K,KARLSON E W,et al.Purine-rich foods,dairy and protein intake,and the risk of gout in men[J].N Engl J Med,2004,350(11):1093-1103. [16] NATH S D,VORUGANTI V S,ARAR N H,et al.Genome scan for determinants of serum uric acid variability[J].J Am Soc Nephrol,2007,18(12):3156-3163. [17] LI Y,SHEN Z Y,ZHU B W,et al.Demographic,regional and temporal trends of hyperuricemia epidemics in mainland China from 2000 to 2019:a systematic review and meta-analysis[J/OL].Glob Health Action,2021,14(1)(2021-01-21)[2021-12-09].https://doi.org/10.1080/16549716.2021.1874652. [18] 尹逸丛,马超超,吴洁,等.SLC22A12及SLC2A9基因多态性与宁夏地区人群低尿酸血症的相关性[J].基础医学与临床,2018,38(5):638-642. YIN Y C,MA C C,WU J,et al.Association of SLC22A12 and SLC2A9 genetic polymorphisms with hypouricemia in Ningxia population[J].Basic Clin Med,2018,38(5):638-642.