The relationship between iodine nutrition during pregnancy and gestational metabolic diseases: a review
JIANG Liubei1, GU Simeng2, WANG Pingping3, WANG Xiaofeng2
1. School of Public Health, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, China; 2. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China; 3. Pujiang County Center for Disease Control and Prevention, Pujiang, Zhejiang 322200, China
Abstract：Iodine is an essential micronutrient for the synthesis of thyroid hormones and for growth and development in the human body. Recent studies have revealed that iodine can exert biological functions beyond the thyroid. By modulating oxidative stress and gut microbiota abundance, it influences systemic metabolic homeostasis. Imbalance in iodine nutrition during pregnancy is closely associated with the onset and progression of gestational metabolic diseases. Based on studies pertaining to the relationship between iodine nutrition during pregnancy and gestational metabolic diseases from 1980 to 2025, this review summarized the relationship of iodine nutrition during pregnancy with gestational metabolic diseases, including gestational diabetes mellitus, gestational hypertension and preeclampsia, gestational overweight or obesity, and gestational dyslipidemia, and described the underlying biological mechanisms, so as to provide the evidence for formulating prevention and control strategies for gestational metabolic diseases.
江柳蓓, 顾思萌, 王平平, 王晓峰. 孕期碘营养与妊娠期代谢性疾病关系的研究进展[J]. 预防医学, 2025, 37(10): 1045-1048.
JIANG Liubei, GU Simeng, WANG Pingping, WANG Xiaofeng. The relationship between iodine nutrition during pregnancy and gestational metabolic diseases: a review. Preventive Medicine, 2025, 37(10): 1045-1048.
[1] ACEVES C,MENDIETA I,ANGUIANO B,et al.Molecular iodine has extrathyroidal effects as an antioxidant,differentiator,and immunomodulator[J/OL].Int J Mol Sci,2021,22(3)[2025-08-21].https://doi.org/10.3390/ijms22031228. [2] GLINOER D.The importance of iodine nutrition during pregnancy[J].Public Health Nutr,2007,10(12A):1542-1546. [3] 李雅晖,王晓峰,莫哲,等. 妊娠期补碘对母体及子代健康影响的研究进展[J].预防医学,2023,35(11):953-956. LI Y H,WANG X F,MO Z,et al.Effects of iodine supplementation during pregnancy on maternal and offspring health:a review[J].China Prev Med J,2023,35(11):953-956.(in Chinese) [4] 张紫琦,屈水令,高群,等.妊娠期糖尿病疾病负担研究现状[J].中国妇幼卫生杂志,2025,16(1):77-80. ZHANG Z Q,QU S L,GAO Q,et al.Research status on the disease burden of gestational diabetes mellitus[J].Chin J Women Child Health,2025,16(1):77-80.(in Chinese) [5] XIAO Y,SUN H K,LI C Y,et al.Effect of iodine nutrition on pregnancy outcomes in an iodine-sufficient area in China[J].Biol Trace Elem Res,2018,182(2):231-237. [6] LI Y H,GU S M,MO Z,et al.Trajectories of maternal urinary iodine concentration are associated with gestational diabetes mellitus[J].Clin Endocrinol(Oxf),2025,102(5):517-525. [7] SILVA DE MORAIS N,AYRES SARAIVA D,CORCINO C,et al.Consequences of iodine deficiency and excess in pregnancy and neonatal outcomes:a prospective cohort study in Rio de Janeiro,Brazil[J].Thyroid,2020,30(12):1792-1801. [8] LI S S,ZHA H Y,CUI Y M,et al.The relationship between excessive iodine during pregnancy and adverse pregnancy complications[J].Endocrine,2025,88(1):203-210. [9] 单晓静,宫建,孙云萍,等.妊娠早期碘营养状态与母体血压关系[J].中国公共卫生,2018,34(12):1698-1699. SHAN X J,GONG J,SUN Y P,et al.Association of iodine nutrition with maternal blood pressure in early pregnancy[J].Chin J Public Health,2018,34(12):1698-1699.(in Chinese) [10] CUELLAR-RUFINO S,NAVARRO-MEZA M,GARCÍA-SOLÍS P,et al.Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease[J].Nutr Hosp,2017,34(3):661-666. [11] BUSINGE C B,PHOHLO K,SEWANI-RUSIKE C.Thyroid peroxidase antibody titers,thyroid function,and iodine nutrition status of pregnant normotensive and preeclamptic women in Eastern Cape South Africa[J/OL].AJOG Glob Rep,2023,3(4)[2025-08-21].https://doi.org/10.1016/j.xagr.2023.100267. [12] BUSINGE C B,LONGO-MBENZA B,KENGNE A P.Iodine deficiency in pregnancy along a concentration gradient is associated with increased severity of preeclampsia in rural Eastern Cape,South Africa[J/OL].BMC Pregnancy Childbirth,2022,22(1)[2025-08-21].https://doi.org/10.1186/s12884-021-04356-6. [13] ABEL M H,CASPERSEN I H,SENGPIEL V,et al.Insufficient maternal iodine intake is associated with subfecundity,reduced foetal growth,and adverse pregnancy outcomes in the Norwegian Mother,Father and Child Cohort Study[J/OL].BMC Med,2020,18(1)[2025-08-21].https://doi.org/10.1186/s12916-020-01676-w. [14] NEVEN K Y,COX B,VRIJENS K,et al.Determinants of placental iodine concentrations in a mild-to-moderate iodine-deficient population:an ENVIRONAGE cohort study[J/OL].J Transl Med,2020,18(1)[2025-08-21].https://doi.org/10.1186/s12967-020-02601-8. [15] LIU Z M,LONG H H,LI D,et al.Maternal serum iodine concentrations in early pregnancy exhibited well diagnostic ability for thyroid dysfunction,inverse associations with gestational weight gain,and birth size:longitudinal analyses based on Huizhou mother-infant cohort[J].Biol Trace Elem Res,2025,203(7):3618-3629. [16] LIU Z M,WU Y,LONG H H,et al.Associations of maternal serum iodine concentration with obstetric complications and birth outcomes-longitudinal analysis based on the Huizhou mother-infant cohort,South China[J/OL].Nutrients,2023,15(13)[2025-08-21].https://doi.org/10.3390/nu15132868. [17] 徐英英,华燕吟,留菁菁,等.血糖波动对糖尿病大鼠甲状腺超微结构的影响研究[J].预防医学,2017,29(1):23-27. XU Y Y,HUA Y Y,LIU J J,et al.A study on the influence of blood glucose fluctuation on the ultra-structure of thyroid gland tissues in diabetes rats[J].China Prev Med J,2017,29(1):23-27.(in Chinese) [18] MOHEBI A,PATHIRANA M M,KHOJA A,et al.Prevalence of metabolic syndrome among pregnant women:a systematic review and meta-analysis[J].Endocrine,2025,88(2):398-409. [19] KIM H J,PARK S,PARK S J,et al.Association between iodine intake and metabolic syndrome in euthyroid adult in an iodine-replete area:a nationwide population-based study[J].Endocr J,2023,70(4):393-401. [20] LLOP S,LOPEZ-ESPINOSA M J,MURCIA M,et al.Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women[J].Environ Res,2015,138:298-305. [21] YANG S Q,SUN J H,WANG S H,et al.Association of exposure to polycyclic aromatic hydrocarbons with thyroid hormones in adolescents and adults,and the influence of the iodine status[J].Environ Sci Process Impacts,2023,25(9):1449-1463. [22] BEN-YEHUDA GREENWALD M,FRUŠIĆ-ZLOTKIN M,SOROKA Y,et al.A novel role of topical iodine in skin:activation of the Nrf2 pathway[J].Free Radic Biol Med,2017,104:238-248. [23] RODRÍGUEZ-CASTELÁN J,DELGADO-GONZÁLEZ E,VARELA-FLORIANO V,et al.Molecular iodine supplement prevents streptozotocin-induced pancreatic alterations in mice[J/OL].Nutrients,2022,14(3)[2025-08-21].https://doi.org/10.3390/nu14030715. [24] RODRÍGUEZ-CASTELÁN J,DELGADO-GONZÁLEZ E,SÁNCHEZ-TAPIA M,et al.Preventive and therapeutic effects of molecular iodine in a model of diabetes mellitus induced by streptozotocin[J/OL].J Nutr Biochem,2025,135[2025-08-21].https://doi.org/10.1016/j.jnutbio.2024.109783. [25] ROSIQUE C,LEBSIR D,BENATIA S,et al.Metabolomics evaluation of repeated administration of potassium iodide on adult male rats[J].Arch Toxicol,2020,94(3):803-812. [26] ZHAO X X,SUN Y,ZHANG H X,et al.Effect of different iodide intake during pregnancy and lactation on thyroid and cardiovascular function in maternal and offspring rats[J/OL].J Trace Elem Med Biol,2023,79[2025-08-21].https://doi.org/10.1016/j.jtemb.2023.127267. [27] HABIBI N,JANKOVIC-KARASOULOS T,LEEMAQZ S Y,et al.Effect of iodine and selenium on proliferation,viability,and oxidative stress in HTR-8/SVneo placental cells[J].Biol Trace Elem Res,2021,199(4):1332-1344. [28] BOKOLIYA S,MCCLELLAN S,ZHOU Y J,et al.Exploring the influence of microbiota on gestational diabetes and its potential as a biomarker[J/OL].Front Bacteriol,2024,3[2025-08-21].https://doi.org/10.3389/fbrio.2024.1352227. [29] WANG J,GU X K,YANG J,et al.Gut microbiota dysbiosis and increased plasma LPS and TMAO levels in patients with preeclampsia[J/OL].Front Cell Infect Microbiol,2019,9[2025-08-21].https://doi.org/10.3389/fcimb.2019.00409. [30] SHEN H T,XU J J,LU C Y,et al.Effects of the sex factor on mouse iodine intake:interactions between the gut microbiota composition and metabolic syndromes[J].ACS Omega,2021,6(43):28569-28578.
