Please wait a minute...
文章检索
预防医学  2023, Vol. 35 Issue (11): 953-956    DOI: 10.19485/j.cnki.issn2096-5087.2023.11.008
  综述 本期目录 | 过刊浏览 | 高级检索 |
妊娠期补碘对母体及子代健康影响的研究进展
李雅晖1, 王晓峰2, 莫哲2综述, 楼晓明2审校
1.杭州医学院公共卫生学院,浙江 杭州 310012;
2.浙江省疾病预防控制中心,浙江 杭州 310051
Effects of iodine supplementation during pregnancy on maternal and offspring health: a review
LI Yahui1, WANG Xiaofeng2, MO Zhe2, LOU Xiaoming2
1. School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang 310012, China;
2. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China
全文: PDF(777 KB)  
输出: BibTeX | EndNote (RIS)      
摘要 碘是人体甲状腺激素合成和生长发育所必需的重要营养素。妊娠期女性的碘需求量大幅增加,碘缺乏可影响自身健康及子代生长发育。采取以食盐加碘为主的补碘措施可改善母体碘营养水平,降低甲状腺功能障碍风险,并可促进子代生长发育、预防智力障碍。但妊娠期过量补碘会影响母体甲状腺功能及子代神经发育,需要根据地区缺碘程度和孕妇个体碘营养状况,制定精准化、差异化补碘方案。本文就妊娠期补碘对母体及子代健康影响研究进行综述,为指导妊娠期合理补碘提供依据。
服务
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章
李雅晖
王晓峰
莫哲
楼晓明
关键词 补碘妊娠期子代甲状腺激素    
Abstract:Iodine is an essential nutrient required for thyroid hormone synthesis and human growth and development. Iodine requirements increase substantially during pregnancy, and insufficient iodine intake may affect the health of pregnant women, and fetal growth and development. Iodized salt-based iodine supplementation is effective to improve maternal iodine levels, reduce risk of thyroid dysfunctions, and plays a vital role in improvements of offspring growth and development and prevention of intellectual disability. However, excessive iodine supplementation during pregnancy may affect maternal thyroid functions and the nerve development of offspring. Precise and personalized iodine supplementation schemes are therefore required tailored to local iodine deficiency degree and pregnant women's individual iodine status. This review summarizes the advances in the impact of iodine supplementation during pregnancy on maternal and offspring health, so as to provide insights into the guidance of iodine supplementation during pregnancy.
Key wordsiodine supplementation    pregnancy    offspring    thyroid hormone
收稿日期: 2023-09-07      修回日期: 2023-10-19      出版日期: 2023-11-10
中图分类号:  R173  
基金资助:浙江省自然科学基金资助项目(TGY23H240001); 国家卫生健康委员会科研基金项目(WKJ-ZJ-2332)
通信作者: 楼晓明,E-mail:xmlou@cdc.zj.cn   
作者简介: 李雅晖,硕士研究生在读
引用本文:   
李雅晖, 王晓峰, 莫哲, 楼晓明. 妊娠期补碘对母体及子代健康影响的研究进展[J]. 预防医学, 2023, 35(11): 953-956.
LI Yahui, WANG Xiaofeng, MO Zhe, LOU Xiaoming. Effects of iodine supplementation during pregnancy on maternal and offspring health: a review. Preventive Medicine, 2023, 35(11): 953-956.
链接本文:  
http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2023.11.008      或      http://www.zjyfyxzz.com/CN/Y2023/V35/I11/953
[1] 日沙来提·塔依尔,吴顺华,王琛琛.妊娠期碘缺乏的研究进展[J]. 中华地方病学杂志,2021,40(9):766-770.
[2] 钱明. 碘对脑发育影响的研究进展[J]. 中华地方病学杂志,2020,39(12):923-926.
[3] LEONARD S A,RASMUSSEN K M,KING J C,et al.Trajectories of maternal weight from before pregnancy through postpartum and associations with childhood obesity[J]. Am J Clin Nutr,2017,106(5):1295-1301.
[4] 中华人民共和国国家卫生健康委员会.全国生活饮用水水碘含量调查报告[EB/OL]. [2023-10-19]. http://www.nhc.gov.cn/jkj/s5874/201905/bb1da1f5e47040e8820b9378e6db4bd3.shtml?ivk_sa=1024320u.
[5] 高四海,张鹤美,林丹,等.温州市居民生活饮用水碘空间分布特征[J]. 预防医学,2019,31(6):564-567.
[6] 中华医学会地方病学分会,中国营养学会,中华医学会内分泌学分会.中国居民补碘指南[M]. 北京:人民卫生出版社,2018:5.
[7] World Health Organization,United Nations International Children's Emergency Fund,International Control Council of Iodin Deficiency Disorders.Assessmet of iodine deficiency disorders and monitoring their elimination:a guide for programme mannnagers[M]. 3rd ed.Geneva:WHO,2007.
[8] KERVER J M,PEARCE E N,MA T,et al.Prevalence of inadequate and excessive iodine intake in a US pregnancy cohort[J]. Am J Obstet Gynecol,2021,224(1):1-8.
[9] MARCHIONI E,FUMAROLA A,CALVANESE A,et al.Iodine deficiency in pregnant women residing in an area with adequate iodine intake[J]. Nutrition,2008,24(5):458-461.
[10] 尼玛仓决,次珍,龚弘强,等.西藏自治区8~10岁儿童和孕妇碘营养监测结果分析[J]. 预防医学,2020,32(4):395-398.
[11] 季巧英,叶夏良,纪律,等.丽水市碘缺乏病监测结果分析[J]. 预防医学,2020,32(2):169-171.
[12] 何礼丹,陈志辉.孕妇尿碘在100~149 μg/L时对其甲状腺功能及子代的影响[J]. 中华地方病学杂志,2021,40(5):426-430.
[13] 王木华,陈迪群,吴佳妮,等.福建省2019年8~10岁儿童及孕妇碘营养水平监测分析[J]. 海峡预防医学杂志,2020,26(5):21-23.
[14] 朱琳,任高翔,郭巧云,等.2019年河南省碘缺乏地区孕妇碘营养监测结果分析[J]. 中国地方病防治,2020,35(6):604-606.
[15] SHENHAV S,BENBASSAT C,GEFEL D,et al.Can mild-to-moderate iodine deficiency during pregnancy alter thyroid function? Lessons from a mother-newborn cohort[J]. Nutrients,2022,14(24):1-16.
[16] YANG S,SHI F T,LEUNG P C,et al.Low thyroid hormone in early pregnancy is associated with an increased risk of gestational diabetes mellitus[J]. J Clin Endocrinol Metab,2016,101(11):4237-4243.
[17] SNART C J P,THREAPLETON D E,KEEBLE C,et al.Maternal iodine status,intrauterine growth,birth outcomes and congenital anomalies in a UK birth cohort[J]. BMC Med,2020,18(1):1-11.
[18] BATH S C.The effect of iodine deficiency during pregnancy on child development[J]. Proc Nutr Soc,2019,78(2):150-160.
[19] NAZERI P,MIRMIRAN P,KABIR A,et al.Neonatal thyrotropin concentration and iodine nutrition status of mothers:a systematic review and meta-analysis[J]. Am J Clin Nutr,2016,104(6):1628-1638.
[20] World Health Organization.Guideline:fortification of food-grade salt with iodine for the prevention and control of iodine deficiency disorders[S]. Geneva:WHO,2014.
[21] 中华人民共和国卫生部.食品安全国家标准食用盐碘含量:GB 26878—2011[S]. 北京:中国标准出版社,2011.
[22] World Health Organization.Assessment of iodine deficiency disorders and monitoring their elimination:a guide for programme managers[S]. Geneva:WHO,2007.
[23] 单忠艳,王临虹.孕产期甲状腺疾病防治管理指南[J]. 中华内分泌代谢杂志,2022,38(7):539-551.
[24] TORRES M T,VILA L,MANRESA J M,et al.Impact of dietary habit,iodine supplementation and smoking habit on urinary iodine concentration during pregnancy in a Catalonia population[J]. Nutrients,2020,12(9):1-15.
[25] MANOUSOU S,EGGERTSEN R,HULTHÉN L,et al.A randomized,double-blind study of iodine supplementation during pregnancy in Sweden:pilot evaluation of maternal iodine status and thyroid function[J]. Eur J Nutr,2021,60(6):3411-3422.
[26] SUN R,QIAN T T,LIU L C,et al.Effect of iodine supplementation on iodine nutrition and thyroid function in pregnant women:a cross-sectional study[J]. Biomed Environ Sci,2022,35:641-647.
[27] TAYLOR P N,OKOSIEME O E,DAYAN C M,et al.Therapy of endocrine disease:Impact of iodine supplementation in mild-to-moderate iodine deficiency:systematic review and meta-analysis[J]. Eur J Endocrinol,2013,170(1):1-15.
[28] NÆSS S,MARKHUS M W,STRAND T A,et al.Iodine nutrition and iodine supplement initiation in association with thyroid function in mildly-to-moderately iodine-deficient pregnant and postpartum women[J]. J Nutr,2021,151(10):3187-3196.
[29] CENSI S,WATUTANTRIGE-FERNANDO S,GROCCIA G,et al.The effects of iodine supplementation in pregnancy on Iodine status,thyroglobulin levels and thyroid function parameters:results from a randomized controlled clinical trial in a mild-to-Moderate iodine deficiency area[J]. Nutrients,2019,11(11):1-13.
[30] DELSHAD H,RAEISI A,ABDOLLAHI Z,et al.Iodine supplementation for pregnant women:a cross-sectional national interventional study[J]. J Endocrinol Invest,2021,44(10):2307-2314.
[31] GOWACHIRAPANT S,JAISWAL N,MELSE-BOONSTRA A,et al.Effect of iodine supplementation in pregnant women on child neurodevelopment:a randomised,double-blind,placebo-controlled trial[J]. Lancet Diabetes Endocrinol,2017,5(11):853-863.
[32] REBAGLIATO M,MURCIA M,ESPADA M,et al.Iodine intake and maternal thyroid function during pregnancy[J]. Epidemiology,2010,21(1):62-69.
[33] GAO M,CHEN W,SUN H,et al.Excessive iodine intake is associated with formation of thyroid nodules in pregnant Chinese women[J]. Nutri Res,2019,66:61-67.
[34] PHAROAH P O,BUTTFIELD I H,HETZEL B S.Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy[J]. Lancet,1971,1(7694):308-310.
[35] SUKKHOJAIWARATKUL D,MAHACHOKLERTWATTANA P,POOMTHAVORN P,et al.Effects of maternal iodine supplementation during pregnancy and lactation on iodine status and neonatal thyroid-stimulating hormone[J]. J Perinatol,2014,34(8):594-598.
[36] ABEL M H,CASPERSEN I H,SENGPIEL V,et al.Insufficient maternal iodine intake is associated with subfecundity,reduced foetal growth,and adverse pregnancy outcomes in the Norwegian Mother,Father and Child Cohort Study[J]. BMC Med,2020,18(1):1-17.
[37] REBAGLIATO M,MURCIA M,ALVAREZ-PEDREROL M,et al.Iodine supplementation during pregnancy and infant neuropsychological development. INMA Mother and Child Cohort Study[J]. Am J Epidemiol,2013,177(9):944-953.
[38] KEVANY J,FIERRO-BENITEZ R,PRETELL E A,et al.Prophylaxis and treatment of endemic goiter with iodized oil in rural Ecuador and Peru[J]. Am J Clin Nutr,1969,22(12):1597-1607.
[39] ABEL M H,YSTROM E,CASPERSEN I H,et al.Maternal iodine intake and offspring attention-deficit/hyperactivity disorder:results from a large prospective cohort study[J]. Nutrients,2017,9(11):1-19.
[40] ZHOU S J,CONDO D,RYAN P,et al.Association between maternal iodine intake in pregnancy and childhood neurodevelopment at age 18 months[J]. Am J Epidemiol,2019,188(2):332-338.
[1] 冀文慧, 常进科, 李弢. 孕期增重过度对子代健康影响的研究进展[J]. 预防医学, 2023, 35(9): 774-777.
[2] 徐佳惠, 卢莎, 胡文胜. 组学技术在妊娠期高血压疾病发病机制及预测研究中的应用进展[J]. 预防医学, 2023, 35(1): 36-40.
[3] 买哈巴·木合塔尔, 古丽达娜·塔布斯别克, 马晓薇, 李宏昀, 江志红, 黎飞海, 吴军. 砷和雌激素水平与甲状腺乳头状癌的关联研究[J]. 预防医学, 2022, 34(6): 577-580.
[4] 陈晓雯, 姜李媛, 陈亚, 郭利芳, 朱旭红. 妊娠晚期贫血的影响因素研究[J]. 预防医学, 2021, 33(12): 1220-1222,1227.
[5] 陈慧琪, 罗琼, 陈光弟. 妊娠期血脂水平与小于胎龄儿相关性研究进展[J]. 预防医学, 2021, 33(1): 41-45.
[6] 关婷, 杨雪莹, 张东梅, 杨娟, 张宏光, 焦楷磊, 马旭, 赵君. 育龄女性孕前促甲状腺激素与空腹血糖水平的关联性研究[J]. 预防医学, 2020, 32(6): 631-635.
[7] 王艳辉, 刘艳平, 卢淑丽. 不良妊娠结局影响因素分析[J]. 预防医学, 2018, 30(3): 303-305.
[8] 周静, 欧荣英, 周美茜, 陈香娟, 包影, 张文淼. HPV感染与不良妊娠结局的关系研究[J]. 预防医学, 2018, 30(1): 12-15.
[9] 李雪波, 邬云妃, 林琳敏, 毛益波. 妊娠期糖尿病患者健康教育干预效果评价[J]. 预防医学, 2017, 29(8): 855-856,860.
[10] 吴金华, 姜雯, 徐海耿, 洪开听, 吕芸, 沈军英, 励夏炜, 莫敏佳, 王硕佳, 余运贤. 孕期甲状腺激素水平与新生儿出生体重的关系[J]. 预防医学, 2017, 29(6): 633-635.
[11] 蔡德雷, 孟真, 汤, 张世鑫, 徐彩菊, 宋燕华. 不同地区10~11岁儿童血铅水平和相关血清学指标研究[J]. 预防医学, 2017, 29(5): 449-451.
[12] 杨秀萍, 舒立波, 顾雪君. 孕妇不同孕期甲状腺激素水平分析[J]. 预防医学, 2017, 29(1): 96-97,100.
[13] 潘晓娜, 邱丽倩. 妊娠期糖尿病的医学营养治疗效果评价[J]. 预防医学, 2016, 28(9): 952-954.
[14] 靳春雷综述, 翁梅芬审校. 妊娠期代谢性疾病个体化营养干预研究进展[J]. 预防医学, 2016, 28(3): 252-255.
[15] 陈青, 卢敏, 籍增洋, 曹真虎. 糖尿病合并酮症酸中毒患者血清甲状腺激素水平分析[J]. 预防医学, 2016, 28(3): 268-269,273.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed