Abstract：Objective To investigate the types and antimicrobial susceptibility of pathogens in AIDS patients with bloodstream infection. Methods Demographic and clinical data of ninety four AIDS patients with bloodstream infection hospitalized in our hospital between 2012 and 2015 were collected. Descriptive analysis was conducted to investigate the types and antimicrobial susceptibility of pathogens of bloodstream infection. Results A total of 109 strains were isolated，including 4 strains of mycobacteria（3.67%），45 strains of gram positive bacteria（41.29%）with Staphylococcus epidermidis ranking first （10.09%），34 gram negative bacteria （31.19%）with Escherichia coli ranking first（7.34%），26 strains of fungi （23.85%），including Talaromyces marneffei（13.76%）and Cryptococcus neoformans（10.09%）. In gram positive bacteria，zero resistance was observed in quinupristin/Dafoe leptin，linezolid，tigecycline，vancomycin，and nitrofurantoin，and the resistance rate was 2.44% with moxifloxacin. In gram negative bacteria，the same drug resistance rate of 8.70% was observed in piperacillin/tazobactam，imipenem and ertapene，respectively. Conclusion In AIDS patients with bloodstream infections，strains include certain opportunistic pathogens，mainly fungi . The pathogens are highly sensitive to the three commonly used line antimicrobial agents .
杨宗兴，叶荣夏，闫俊，师金川，朱明利，喻剑华. 艾滋病合并血流感染病原体种类及耐药分析[J]. 预防医学, 2018, 30(9): 874-878.
YANG Zong-xing，YE Rong-xia，YAN Jun，SHI Jin-chuan，ZHU Ming-li，YU Jian-hua. Analysis of types and antimicrobial susceptibility of pathogens in AIDS patients with bloodstream infection. Preventive Medicine, 2018, 30(9): 874-878.
[1] HUSON M，STOLP S，VAN DER POLL T，et al. Community-acquired bacterial bloodstream infections in HIV-infected patients：a systematic review[J] . Clin Infect Dis，2014，58（1）：79-92. [2] 赵贺红，冯萍，肖贵宝，等. 艾滋病合并机会性感染的临床特征和诊疗分析[J] . 华西医学，2011，26（10）：1496-1500. [3] 朱晓红. 艾滋病患者合并机会性感染的临床特点和预后分析[J] . 中国继续医学教育，2017，9（17）：106-107. [4] TARAMASSO L，TATARELLI P，DI BIAGIO A. Bloodstream infections in HIV-infected patients[J] . Virulence，2016，7（3）：320-328. [5] 杨宗兴，吴南屏. 艾滋病患者血流感染的研究[J] . 国际流行病学传染病学杂志，2012，39（2）：129-133. [6] 中华医学会感染病学分会艾滋病学组. 艾滋病诊疗指南（2011版） [J] . 中华传染病杂志，2011，29（10）：321-330. [7] 中华医学会检验医学分会. 临床微生物学血培养操作规范[J] . 中华检验医学杂志，2004，27（2）：124-126. [8] 陆永绥，张伟民. 临床检验管理与技术规程（第二版） [M] . 杭州：浙江大学出版社，2014. [9] PHE T，VLIEGHE E，REID T，et al. Does HIV status affect the aetiology，bacterial resistance patterns and recommended empiric antibiotic treatment in adult patients with bloodstream infection in Cambodia?[J] . Trop Med Int Health，2013，18（4）：485-494. [10] HARBOE Z，LARSEN M，LADELUND S，et al. Incidence and risk factors for invasive pneumococcal disease in HIV-infected and non-HIV-infected individuals before and after the introduction of combination antiretroviral therapy：persistent high risk among HIV-infected injecting drug users[J] . Clin Infect Dis，2014，59（8）：1168-1176. [11] 许世申，陈国伟. 艾滋病合并败血症52例临床特点和病原菌分析[J] . 北方药学，2015，12（5）：165-166. [12] ZHENG J，GUI X，CAO Q，et al. A clinical study of acquired immunodeficiency syndrome associated penicillium marneffei infection from a non-endemic area in China[J] . PLoS ONE，2015，10（6）：e0130376. [13] 赵敬焕，刘迪，李亭，等. 血流感染患者的病原菌分析[J] . 中国感染与化疗杂志，2012，12（5）：384-389. [14] JACOB S T，PAVLINAC P B，NAKIYINGI L，et al. Mycobacterium tuberculosis bacteremia in a cohort of hiv-infected patients hospitalized with severe sepsis in uganda-high frequency，low clinical suspicion [corrected] and derivation of a clinical prediction score[J] . PLoS ONE，2013，8（8）：e70305. [15] KIERTIBURANAKUL S，WATCHARATIPAGORN S，CHONGTRAKOOL P，et al. Epidemiology of bloodstream infections and predictive factors of mortality among HIV-infected adult patients in Thailand in the era of highly active antiretroviral therapy[J] . Japanese Journal of Infectious Diseases，2012，65（1）：28. [16] CRUMP J A，RAMADHANI H O，MORRISSEY A B，et al. Bacteremic disseminated tuberculosis in Sub-Saharan Africa：a prospective cohort study[J] . Clinical Infectious Diseases，2012， 55（2）：242-250. [17] BEDELL R A，ANDERSON S T，VAN L M，et al. High prevalence of tuberculosis and serious bloodstream infections in ambulatory individuals presenting for antiretroviral therapy in Malawi[J] . PLoS ONE，2012，7（6）：e39347. [18] 孙炜，叶米，汪霞梅，等. 肺结核患者与艾滋病病毒感染者双向筛检效果分析[J] . 预防医学，2016，28（3）：259-261. [19] 浙江省卫生和计划生育委员会.关于加强抗菌药物临床应用分级管理工作的通知[Z] . 2016. [20] 周美儿，叶玲，王玲露，等. 某县级中医院医院感染资料分析[J] . 预防医学，2018，30（5）：485-489. [21] 贾磊，余运贤，陆锦琪，等. 某医院耐碳青霉烯类肠杆菌科细菌分布特征分析[J] . 浙江预防医学，2017，29（8）：799-800.
