Please wait a minute...
文章检索
预防医学  2018, Vol. 30 Issue (4): 382-386    DOI: 10.19485/j.cnki.issn2096-5087.2018.04.016
  论著 本期目录 | 过刊浏览 | 高级检索 |
再生障碍性贫血发病影响因素的Meta分析
李秋爽1,沈怡雯2,季聪华1,刘姗1,张颖1
1.浙江省中医院临床评价中心,浙江 杭州 310006;
2.浙江中医药大学基础医学院
Risk factors of aplastic anemia:A Meta-analysis
LI Qiu-shuang*,SHEN Yi-Wen,JI Cong-hua,LIU Shan,ZHANG Ying
*The Center of Clinical Evaluation and Analysis of Zhejiang Provincial Hospital of TCM,Hangzhou,Zhejiang 310016,China
全文: PDF(548 KB)  
输出: BibTeX | EndNote (RIS)      
摘要 目的 分析再生障碍性贫血发病的危险因素,为一级预防提供依据。方法 以“再生障碍性贫血”“病例对照研究”“危险因素”等为关键词,检索中国期刊全文数据库、维普中文科技期刊数据库等中文数据库;以“aplastic anemia”“case-control study”“risk factor” 等为关键词,检索PubMed、Cochrane Library等外文数据库,查找关于再生障碍性贫血发病危险因素的相关研究文献,时间范围为建库至2017年9月。采用Stata 14.0 软件进行Meta分析,计算合并OR值。结果 共检索到1 094篇文献,最终纳入22篇文献,均为病例对照研究,共涉及16项危险因素。Meta分析结果显示,油漆接触(OR=3.82,95%CI:1.68~8.66)、氯霉素使用(OR=3.21,95%CI:1.98~5.20)、苯接触(OR=2.94,95%CI:2.11~4.11)、胶水接触(OR=2.56,95%CI:1.28~5.12)、肝炎病史(OR=2.54,95%CI:1.94~3.34)、染发剂接触(OR=2.37,95%CI:1.08~5.22)、农药接触(OR=1.98,95%CI:1.60~2.45)、β-内酰胺(OR=1.77,95%CI:1.03~3.06)、磺胺类(OR=1.64,95%CI:1.03~2.61)和燃料/石油接触(OR=1.53,95%CI:1.25~1.87)等10个因素是再生障碍性贫血发病的危险因素;高经济收入(OR=0.52,95%CI:0.43~0.63)是再生障碍性贫血发病的保护因素。结论 再生障碍性贫血的危险因素主要涉及药物使用、既往史、社会经济地位和职业或环境接触化学毒物等。
服务
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章
李秋爽
沈怡雯
季聪华
刘姗
张颖
关键词 再生障碍性贫血危险因素Meta分析    
AbstractObjective To comprehensively evaluate the risk factors of aplastic anemia,and provide scientific evidence for the primary prevention of aplastic anemia.Methods The published Papers were searched by“aplastic anemia”“case control study”and“risk factors”as key words collected from Chinese National Knowledge Infrastructure,Chinese VIP journal database,PubMed,Cochrane library and Clinical Trial and other databases,ranged from the creation date of each database to September 2017 .A meta-analysis of studies on risk factors was performed to calculate the pooled odd ratios(ORs)with 95% confidence intervals(CIs)with Software Stata 14.0.Results The database search resulted in the identification of 1,094 articles. After screening,22 case-control studies were included in the study with 16 factors. Ten risk factors were showed statistically significant differences,including paint exposure(OR=3.82,95%CI:1.68-8.66),chloramphenicol(OR=3.21, 95%CI:1.98-5.20),benzene exposure(OR=2.94,95%CI:2.11-4.11),glue exposure(OR=2.56,95%CI:1.28-5.12),history of hepatitis(OR=2.54,95%CI:1.94-3.34),hair dye exposure(OR=2.37,95%CI:1.08-5.22),pesticides exposure(OR=1.98,95%CI:1.60-2.45),β-lactam(OR=1.77,95%CI:1.03-3.06),sulfonamides(OR=1.64,95%CI:1.03-2.61)and fuel/oil exposure(OR=1.53,95%CI:1.25-1.87),and high economic income(OR=0.52,95%CI:0.43-0.63)is the protective factor.Conclusion The meta-analysis of case-control studies suggests that the risk factors of aplastic anemia mainly including four aspects:drug use,past history,socioeconomic status and occupational or environmental exposure to chemical toxic substances.
Key wordsAplastic anemia    Risk factors    Meta-analysis
          出版日期: 2018-03-26
中图分类号:  R556.5  
基金资助:浙江省教育厅科研项目(Y201636810);浙江省中医药科学研究基金项目(2016ZA062)
通信作者: 季聪华,E-mail:jchi_2005@163.com   
作者简介: 李秋爽,硕士,助理研究员,主要从事中医临床科研方法学和循证医学研究工作
引用本文:   
李秋爽,沈怡雯,季聪华,刘姗,张颖. 再生障碍性贫血发病影响因素的Meta分析[J]. 预防医学, 2018, 30(4): 382-386.
LI Qiu-shuang*,SHEN Yi-Wen,JI Cong-hua,LIU Shan,ZHANG Ying. Risk factors of aplastic anemia:A Meta-analysis. Preventive Medicine, 2018, 30(4): 382-386.
链接本文:  
http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2018.04.016      或      http://www.zjyfyxzz.com/CN/Y2018/V30/I4/382
[1] YOUNG N S,CALADO R T,SCHEINBERG P. Current concepts in the pathophysiology and treatment of aplastic anemia[J] . Blood,2006,108(8):2509-2519.
[2] OREJA I L,AMARIKA I,DIEZ R A,et al. Incidence and epidemiology of aplastic anemia. A retrospective study of the Northern Society of Hematology (ASOVASNA)[J] . 2016,51:S289.
[3] WILLIAMS D A,BENNETT C,BERTUCH A,et al. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA):an initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)[J] . Pediatr Blood Cancer,2014,61(5):869-874.
[4] 张之南. 血液病诊断及疗效标准[M] . 3版. 北京:科学出版社,2011:19-23.
[5] BAUMELOU E,GUIGUET M,MARY J Y. Epidemiology of aplastic anemia in France:a case-control study. I. Medical history and medication use. The French Cooperative Group for Epidemiological Study of Aplastic Anemia[J] . Blood,1993,81(6):1471-1478.
[6] 林果为,林佩娣,杨子文,等. 病毒性肝炎和再生障碍性贫血发病关系的临床流行病学研究[J] . 中华血液学杂志,1994,15(4):171-173.
[7] ISSARAGRISIL S,KAUFMAN D W,ANDERSON T E,et al. An association of aplastic anaemia in Thailand with low socioeconomic status. Aplastic Anemia Study Group[J] . Br J Haematol,1995, 91(1):80-84.
[8] GUIGUET M,BAUMELOU E,MARY J Y. A case-control study of aplastic anaemia:occupational exposures. The French Cooperative Group for Epidemiological Study of Aplastic Anaemia[J] . International Journal of Epidemiology,1995,24(5):993-999.
[9] KAUFMAN D W,KELLY J P,JURGELON J M,et al. Drugs in the aetiology of agranulocytosis and aplastic anaemia[J] . Eur J Haematol Suppl,1996,60:23-30.
[10] ISSARAGRISIL S,KAUFMAN D W,ANDERSON T. Incidence and non-drug aetiologies of aplastic anaemia in Thailand. The Thai Aplastic Anaemia Study Group[J] . Eur J Haematol Suppl,1996,60:31-34.
[11] MARY J Y,GUIGUET M,BAUMELOU E. Drug use and aplastic anaemia:the French experience. French Cooperative Group for the Epidemiological Study of Aplastic Anaemia[J] . Eur J Haematol Suppl,1996,60:35-41.
[12] ISSARAGRISIL S,CHANSUNG K,KAUFMAN D W,et al. Aplastic anemia in rural Thailand:its association with grain farming and agricultural pesticide exposure. Aplastic Anemia Study Group[J] . Am J Public Health,1997,87(9):1551-1554.
[13] ISSARAGRISIL S,KAUFMAN D,THONGPUT A,et al. Association of seropositivity for hepatitis viruses and aplastic anemia in Thailand[J] . Hepatology,1997,25(5):1255-1257.
[14] ISSARAGRISIL S,KAUFMAN D W,ANDERSON T,et al. Low drug attributability of aplastic anemia in Thailand. The Aplastic Anemia Study Group[J] . Blood,1997,89(11):4034-4039.
[15] LAPORTE J R,IBáEZ L,BALLARíN E,et al. Fatal aplastic anaemia associated with nifedipine[J] . Lancet,1998,352(9128):619-620.
[16] LAPORTE J R,VIDAL X,BALLARIN E,et al. Possible association between ocular chloramphenicol and aplastic anaemia-the absolute risk is very low[J] . British Journal of Clinical Pharmacology,2002,46(2):181-184.
[17] MALUF E M,PASQUINI R,ELUF J N,et al. Aplastic anemia in Brazil:incidence and risk factors[J] . Am J Hematol,2002,71(4):268-274.
[18] MUIR K R,CHILVERS C E,HARRISS C,et al. The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia:a case control investigation[J] . Br J Haematol,2003,123(5):906-914.
[19] 全国再生障碍性贫血协作组. 再生障碍性贫血危险因素的病例对照研究[J] . 中华血液学杂志,2003,24(11):599-601.
[20] ISSARAGRISIL S,KAUFMAN D W,ANDERSON T,et al. The epidemiology of aplastic anemia in Thailand[J] . Blood,2006, 107(4):1299-1307.
[21] MALUF E,HAMERSCHLAK N,CAVALCANTI A B,et al. Incidence and risk factors of aplastic anemia in Latin American countries:the LATIN case-control study[J] . Haematologica,2009,94(9):1220-1226.
[22] GROSS S A,IRONS R D,SCHNATTER A R,et al. A hospital-based case control study of aplastic anemia in Shanghai,China[J] . Chem Biol Interact,2010,184(1-2):165-173.
[23] 顾明华,高香,朱静怡,等. 成人再生障碍性贫血危险因素的病例-对照研究[J] . 中国工业医学杂志,2012,25(2):87-90.
[24] 沈英英,陈智,林圣云,等. 再生障碍性贫血的多危险因素病例对照研究[J] . 临床血液学杂志,2014,27(4):564-569.
[25] MALHOTRA P,GELLA V,GURU MURTHY G S,et al. High incidence of aplastic anemia is linked with lower socioeconomic status of Indian population[J] . J Public Health (Oxf),2016,38(2):223-228.
[26] 朱艳,匡跃敏,林圣云,等. 再生障碍性贫血与化学毒物相关分析[J] . 预防医学,2016,28(7):700-701,705.
[27] 胡南霞,刘毅,李艳君,等. 病毒性肝炎与获得性再生障碍性贫血关系的病例-对照研究Meta分析[J] . 医学研究杂志,2015,44(11): 105-110.
[1] 贾铭, 彭菊意, 刘星宇, 刘宇丹, 赵华. 心血管代谢性共病危险因素的Meta分析[J]. 预防医学, 2023, 35(9): 790-795.
[2] 刘溦, 宋杰, 陈伟伟, 叶丁, 毛盈颖. 硒水平与慢性肾脏病关联的Meta分析[J]. 预防医学, 2023, 35(8): 669-676.
[3] 柏旭, 苏洁, 李凤, 徐倩, 沈源, 肖凌凤. 我国成人糖尿病视网膜病变影响因素的Meta分析[J]. 预防医学, 2023, 35(7): 595-601.
[4] 张媛, 韩正风, 马艳. 老年人群肌少症危险因素的病例对照研究[J]. 预防医学, 2023, 35(6): 461-464.
[5] 丁承辉, 吴萃, 薛琨, 励晓红, 万金豹, 陈秋艳, 朱潇翔. 宝山区糖尿病高危人群筛查结果分析[J]. 预防医学, 2023, 35(6): 509-513.
[6] 段恬筱, 黄希汇, 刘诗川, 胡薇薇, 刘涛, 李亚, 岑斌. 新型冠状病毒感染流行期间医护人员职业倦怠的Meta分析[J]. 预防医学, 2023, 35(6): 526-532.
[7] 方子思, 廖辉, 周筱丛, 徐虹. 我国公共场所集中空调通风系统嗜肺军团菌污染的Meta分析[J]. 预防医学, 2023, 35(5): 425-430.
[8] 黄文, 汤佳良, 陈康康, 黄敏钢, 陈奇峰. 绍兴市心血管疾病高危人群危险因素聚集分析[J]. 预防医学, 2023, 35(4): 298-302,330.
[9] 张家佳, 陈小玉, 卿雪莲. 我国空巢老人跌倒发生率的Meta分析[J]. 预防医学, 2023, 35(10): 844-848,855.
[10] 何亚盛, 张红霞, 倪银, 朱越燕, 彭敏, 杨丹红. 急诊重症监护病房住院患者医院感染的预测模型研究[J]. 预防医学, 2022, 34(9): 919-922.
[11] 罗环, 梁婧, 张非若, 贾宁, 王忠旭, 王如刚. 北京市重型汽车零部件生产企业工人职业性肌肉骨骼疾患调查[J]. 预防医学, 2022, 34(8): 809-815.
[12] 沈强, 张月琴, 江圣洁, 甘露, 尉莹莹. 新冠肺炎疫情期间医务人员焦虑状况的Meta分析[J]. 预防医学, 2022, 34(7): 720-726.
[13] 张洁, 费方荣, 胡如英, 龚巍巍, 钟节鸣. 浙江省慢性病主要危险因素的归因疾病负担研究[J]. 预防医学, 2022, 34(6): 541-546,554.
[14] 杨丹丹, 姚学成, 张昕涵, 唐梦龄, 王建炳, 金明娟, 陈坤. 中国人群胃癌发病影响因素的Meta分析[J]. 预防医学, 2022, 34(6): 561-570.
[15] 郑云枝, 侯灿灿, 曹锦程, 崔总文, 王茂, 崔俊鹏. 心肺适能与心脑血管疾病发病关系的Meta分析[J]. 预防医学, 2022, 34(3): 282-288,293.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed