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预防医学  2022, Vol. 34 Issue (3): 282-288,293    DOI: 10.19485/j.cnki.issn2096-5087.2022.03.014
  疾病控制 本期目录 | 过刊浏览 | 高级检索 |
心肺适能与心脑血管疾病发病关系的Meta分析
郑云枝1, 侯灿灿2, 曹锦程2, 崔总文3, 王茂4, 崔俊鹏5
1.许昌市魏都区疾病预防控制中心慢性病防治科,河南 许昌 461000;
2.许昌市疾病预防控制中心,河南 许昌 461000;
3.巩义市人民医院,河南 巩义 451200;
4.淅川县人民医院,河南 淅川 474450;
5.开封市结核病防治所,河南 开封 475000
Association between cardiorespiratory fitness and the risk of cardiovascular and cerebrovascular diseases: a meta-analysis
ZHENG Yunzhi1, HOU Cancan2, CAO Jincheng2, CUI Zongwen3, WANG Mao4, CUI Junpeng5
1. Department of Chronic Disease Control and Prevention, Weidu Center for Disease Control and Prevention, Xuchang, Henan 461000, China;
2. Xuchang Center for Disease Control and Prevention, Xuchang, Henan 461000, China;
3. Gongyi People's Hospital, Gongyi, Henan 451200, China;
4. Xichuan County People's Hospital, Xichuan, Henan 474450, China;
5. Kaifeng Tuberculosis Prevention and Control Institute, Kaifeng, Henan 475000, China
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摘要 目的 系统分析心肺适能(CRF)与心脑血管疾病发病的剂量-反应关系。方法 检索中国知网、万方数据、维普中文科技期刊数据库和PubMed等中英文期刊数据库,收集建库至2021年5月关于CRF与心脑血管疾病关系研究的文献进行Meta分析;采用随机效应模型评估合并风险,采用限制性立方样条模型评估剂量-反应关系;采用亚组分析评估异质性来源;采用剪补法检验结果的稳定性;采用漏斗图评估发表偏倚。结果 检索相关文献37 280篇,最终纳入符合条件的23篇,样本量共2 605 622人,其中22篇为高质量文献。Meta分析结果显示:CRF最高组合并的心脑血管疾病发病风险较最低组下降42%(OR=0.58,95%CI:0.52~0.65);CRF每上升1代谢当量(MET),合并的心脑血管疾病发病风险下降10%(OR=0.90,95%CI:0.88~0.92);CRF与心脑血管疾病发病之间存在负线性相关关系(P=0.396)。亚组分析结果显示性别、样本量和地区可能是异质性来源。敏感性分析显示结果稳定。结论 CRF与心脑血管疾病存在负线性相关关系,提高CRF 可降低心脑血管疾病发病风险。
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郑云枝
侯灿灿
曹锦程
崔总文
王茂
崔俊鹏
关键词 心肺适能心脑血管疾病剂量-反应关系Meta分析    
AbstractObjective To examine the dose-response association between cardiorespiratory fitness ( CRF ) and the risk of cardiovascular and cerebrovascular diseases. Methods A joint search was performed in Chinese and English electronic databases, including China National Knowledge Infrastructure ( CNKI ) , Wanfang Data, VIP, CBM, PubMed, Embase and Web of Science, to retrieve publications reporting the correlation between CRF and the risk of cardiovascular and cerebrovascular diseases until May, 2021. The pooled risk was estimated using the random effects model, and the dose-response association was evaluated using restricted cubic splines. The source of heterogeneity was assessed by subgroup analysis, and the stability of the results was tested by the trim-and-fill method, while the publication bias was assessed using funnel plots. Results Totally 37 280 literatures were identified, and 23 eligible studies were finally included in the analysis, which covered 2 605 622 subjects. There were 22 publications identified as high-quality. Meta-analysis revealed that the pooled risk of cardiovascular and cerebrovascular diseases reduced by 42% in the highest CRF group relative to the lowest CRF group ( OR=0.58, 95%CI: 0.52-0.65 ), and a one metabolic equivalent ( MET ) increase in CRF caused a 10% reduction in the pooled risk of cardiovascular and cerebrovascular diseases ( OR=0.90, 95%CI: 0.88-0.92 ). There was a negative linear correlation between CRF and the incidence of cardiovascular and cerebrovascular diseases ( P=0.396 ). Subgroup analysis identified gender, sample size and study regions as possible sources of heterogeneity, and sensitivity analysis showed that the study results were stable. Conclusions There is a negative linear correlation between CRF and the risk of cardiovascular and cerebrovascular diseases, and an increase in CRF may reduce the risk of cardiovascular and cerebrovascular diseases.
Key wordscardiorespiratory fitness    cardiovascular and cerebrovascular diseases    dose-response association    meta-analysis
收稿日期: 2021-06-30      修回日期: 2021-11-08      出版日期: 2022-03-10
中图分类号:  R54  
通信作者: 郑云枝,E-mail:xcwd000@163.com   
作者简介: 郑云枝,本科,副主任医师,主要从事慢性病预防控制工作
引用本文:   
郑云枝, 侯灿灿, 曹锦程, 崔总文, 王茂, 崔俊鹏. 心肺适能与心脑血管疾病发病关系的Meta分析[J]. 预防医学, 2022, 34(3): 282-288,293.
ZHENG Yunzhi, HOU Cancan, CAO Jincheng, CUI Zongwen, WANG Mao, CUI Junpeng. Association between cardiorespiratory fitness and the risk of cardiovascular and cerebrovascular diseases: a meta-analysis. Preventive Medicine, 2022, 34(3): 282-288,293.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2022.03.014      或      http://www.zjyfyxzz.com/CN/Y2022/V34/I3/282
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