Amplitude of low-frequency fluctuations of behavioral characteristics in different phenotypes of attention deficit hyperactivity disorder
WANG Qipeng1,2,3, CAO Longfei2,3, ZHANG Hang2,3, FANG Yantong2,3, YE Baojuan1
1. School of Psychology, Jiangxi Normal University, Nanchang, Jiangxi 330000, China; 2. Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015; 3. Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairment, Hangzhou, Zhejiang 310015, China
Abstract：Objective To investigate the difference in behavioral characteristics among different phenotypes of attention deficit hyperactivity disorder (ADHD) using amplitude of low-frequency fluctuation (ALFF), so as to provide insights into clinical differentiation of behavioral characteristics among different phenotypes of ADHD. Methods The children with ADHD admitted to The Affiliated Hospital of Hangzhou Normal University were enrolled and classified into the inattentive type (ADHD-I), hyperactive/impulsive type (ADHD-HI) and combined type (ADHD-C). The reaction time (RT) was measured using integrated visual and auditory continuous performance test, and the mean (RT-mean) and standard deviation of RT (RT-SD) were estimated. In addition, the ALFF was calculated at 0.010 to 0.027, 0.027 to 0.073, 0.073 to 0.167 Hz, and the difference of ALFF was compared among children with different types of ADHD. Results A total of 107 children with ADHD were enrolled, including 95 boys and 12 girls, with a mean age of (8.89±1.93) years. There were 69 children with ADHD-I, 8 children with ADHD-HI and 30 children with ADHD-C. The RT-SD was significantly higher among children with ADHD-C than among children with ADHD-I [(126.003±51.619) ms vs. (97.720±45.302) ms; P=0.007]; however, there was no significant difference in RT-mean among children with various ADHD phenotypes (F=1.386, P=0.255). There was an interaction between frequency and ADHD phenotypes (F=2.754, P=0.032), and the ALFF was significantly higher among children with ADHD-C than among children with ADHD-I at 0.010 to 0.027 [(5 590.567±231.595) ms vs. (4 694.001±154.397) ms; P=0.002] and 0.073 to 0.167 Hz [(4 312.609±174.709) ms vs. (3 690.805±116.473) ms; P=0.005]. Conclusions The ALFF varies in ADHD phenotypes, and there is a frequency-specific difference.
王其鹏, 曹龙飞, 张行, 方妍彤, 叶宝娟. 注意缺陷多动障碍不同表现型的反应时低频振幅研究[J]. 预防医学, 2022, 34(7): 747-750,755.
WANG Qipeng, CAO Longfei, ZHANG Hang, FANG Yantong, YE Baojuan. Amplitude of low-frequency fluctuations of behavioral characteristics in different phenotypes of attention deficit hyperactivity disorder. Preventive Medicine, 2022, 34(7): 747-750,755.
[1] 陈文材,佐飞燕,万莹,等.脑源性神经营养因子基因Val66Met多态性与注意缺陷多动障碍易感性的Meta分析[J].中国儿童保健杂志,2022,30(3):301-305,324. CHEN W C,ZUO F Y,WAN Y,et al.Meta-analysis on the association between brain derived neurotrophic factor Val66Met gene polymorphism and attention deficit hyperactivity disorder[J].Chin J Child Health Care,2022,30(3):301-305,324. [2] American Psychiatric Association.Diagnostic and statistical manual of mental disorders[M].5th ed.Arlington:American Psychiatric Pub,2013. [3] 王飞英,倪钰飞,陆梅娟,等.游戏疗法对注意缺陷多动障碍儿童的干预效果[J].中国妇幼保健,2021,36(15):3488-3490. WANG F Y,NI Y F,LU M J,et al.A study on the intervention effect of play therapy on children with attention deficit hyperactivity disorder[J].Matern Child Health Care China,2021,36(15):3488-3490. [4] MOLAVI P,NADEMOHAMMADI M,SALVAT GHOJEHBEIGLOU H,et al.ADHD subtype-specific cognitive correlates and association with self-esteem:a quantitative difference[J/OL].BMC Psychiatry,2020,20(1)[2022-06-06].https://doi.org/10.1186/s12888-020-02887-4. [5] CASTEKKANOS F X,SONUGA-BARKE E J,SCHERES A,et al.Varieties of attention-deficit/hyperactivity disorderrelated intra-individual variability[J].Biol Psychiatry,2005,57(11),1416-1423. [6] TAMM L,NARAD M E,ANTONINI T N,et al.Reaction time variability in ADHD:a review[J].Neurotherapeutics,2012,9(3):500-508. [7] 周旭峰. 持续实时指压反馈范式行为学指标重测信度及脑机制研究[D].杭州:杭州师范大学,2020. ZHOU X F.Brain mechanism and test-retest reliability of behavior measurements in continuous real-time feedback of finger force paradigm[D].Hangzhou:Hangzhou Normal University,2020. [8] 天津市内分泌研究所,天津医科大学医学心理教研室.中国联合型瑞文测验CRT-C2图册[Z].2007. WANG Y Y,SUN L,LIU Y W,et al.The low-frequency fluctuation of trial-by-trial frontal theta activity and its correlation with reaction-time variability in sustained attention[J].Front Psychol,2020[2022-06-06]. https://doi.org/10.3389/fpsyg.2020.01555. [10] MAIRENA M Á,DI MARTINO A,DOMÍNGUEZ-MARTÍN C,et al.Low frequency oscillations of response time explain parent ratings of inattention and hyperactivity/impulsivity[J].Eur Child Adolesc Psychiatry,2012,21(2),101-109. [11] KOFLER M J,RAPPORT M D,SARVER D E,et al.Reaction time variability in ADHD:a meta-analytic review of 319 studies[J].Clin Psychol Rev,2013,33(6):795-811. [12] VAURIO R G,SIMMONDS D J,MOSTOFSKY S H.Increased intra-individual reaction time variability in attention-deficit/hyperactivity disorder across response inhibition tasks with different cognitive demands[J].Neuropsychologia,2009,47(12):2389-2396.
