Abstract：Objective To investigate the behavioral and psychological symptoms of dementia（BPSD）in patients with Alzheimer's disease（AD）by measuring the amplitude of low-frequency fluctuation（ALFF）in functional magnetic resonance imaging（fMRI ）.Methods The AD patients with BPSD treated at the First People's Hospital of Hangzhou were enrolled as the case group,and the matched healthy elderly were unified recruited as the control group. The case group was further divided into two groups by neuropsychiatric inventory（NPI）questionnaire as the severe BPSD group and the mild BPSD group. All the three groups were separately received fMRI scan in resting state and compared by analysis of ALFF,and the specific damage manifestation of imaging features in the three groups were analyzed .Results There were 12 people in the control group and 24 AD patients with BPSD in the case group,with 12 patients in the mild BPSD group and 12 patients in the severe BPSD group. Compared with the control group,the activated areas of the mild BPSD group were in the middle temporal gyrus,medial frontal gyrus,inferior parietal lobe,middle frontal gyrus and posterior cerebellar lobe,and the weakened areas were in the superior temporal gyrus,occipital lobe,anterior cuneate lobe and posterior central gyrus. In the severe BPSD group,the activated areas were in the posterior cerebellum,superior temporal gyrus and temporal lobe,and the weakened areas were in the middle occipital gyrus,posterior cingulate gyrus,parietal lobe,anterior cuneate lobe,frontal lobe and middle frontal gyrus. The ALFF values of brain activated and weakened areas in the mild BPSD group and the severe BPSD group were significantly different from those in the control group （P<0.01）. Compared with the mild BPSD group,the activated areas were in the lower parietal lobe,and the weakened areas were in the fusiform gyrus,lingual gyrus and middle temporal gyrus. The ALFF values in the activated areas and weakened areas between the severe BPSD group and the mild BPSD group were significantly different（P<0.01）.Conclusion AD patients with BPSD have impaired resting default network areas,and visual,attention,emotional and cognitive regulatory networks are impaired as psychiatric symptoms worsen.
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