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预防医学  2022, Vol. 34 Issue (4): 419-423,428    DOI: 10.19485/j.cnki.issn2096-5087.2022.04.020
  妇幼保健 本期目录 | 过刊浏览 | 高级检索 |
大理白族自治州女性绝经后骨质疏松的影响因素分析
高玉婕, 陈晓云, 沙艳梅, 王晓芬, 韩光翡, 黎伟娟, 杨蕾, 闻海梅, 胡学琴
大理州人民医院老年病科,云南 大理 671000
Factors affecting postmenopausal osteoporosis in Dali Bai Autonomous Prefecture
GAO Yujie, CHEN Xiaoyun, SHA Yanmei, WANG Xiaofen, HAN Guangfei, LI Weijuan, YANG Lei, WEN Haimei, HU Xueqin
Department of Geriatrics, Dali Prefecture People's Hospital, Dali, Yunnan 671000, China
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摘要 目的 了解云南省大理白族自治州50~59岁白族女性绝经后骨质疏松(PMOP)的患病情况并分析其影响因素,为绝经期女性预防PMOP提供依据。方法 选择2017年6月—2021年5月在大理州人民医院体检中心健康体检的50~59岁绝经白族女性为研究对象。采用自行设计的问卷收集人口学信息、生活习惯、疾病史和既往史等资料;测量身高、体重和骨密度;实验室检测空腹血糖(GLU)、维生素D3、肝功能和血脂指标等;采用多因素logistic回归模型分析PMOP的影响因素。结果 发放问卷2 000份,回收有效问卷1 584份,回收有效率为79.20%。年龄为(56.22±2.61)岁。体质指数(BMI)为(24.62±2.35)kg/m2。有骨质疏松(OP)家族史497人,占31.38%。检出PMOP 327例,检出率为20.64%。多因素logistic回归分析结果显示,年龄(OR=1.135,95%CI:1.074~1.196)、初潮年龄(OR=1.138,95%CI:1.059~1.217)、绝经年限(OR=1.425,95%CI:1.228~1.622)、生育次数>2次(OR=5.036,95%CI:2.972~7.101)、吸烟(OR=2.594,95%CI:1.767~3.421)、饮酒(OR=2.051,95%CI:1.503~2.598)、OP家族史(OR=2.540,95%CI:1.769~3.311)、高血压(OR=1.492,95%CI:1.406~1.578)、糖尿病(OR=1.774,95%CI:1.581~1.967)、总胆固醇(OR=1.483,95%CI:1.251~1.716)、三酰甘油(OR=1.801,95%CI:1.576~2.026)、低密度脂蛋白胆固醇(OR=1.614,95%CI:1.498~1.731)、GLU(OR=1.192,95%CI:1.077~1.307)、BMI(OR=0.934,95%CI:0.862~0.993)、户外运动≥1次/周(OR:0.413~0.549,95%CI:0.329~0.637)、绝经年龄(OR=0.909,95%CI:0.841~0.977)、每日钙摄入量≥600 mg(OR:0.493~0.644,95%CI:0.389~0.786)、维生素D3≥20 ng/mL(OR:0.604~0.719,95%CI:0.523~0.853)和高密度脂蛋白胆固醇(OR=0.658,95%CI:0.550~0.767)是PMOP的影响因素。结论 大理白族自治州女性PMOP患病率与全国水平接近,高龄、吸烟、饮酒、有OP家族史和血脂水平高均会增加PMOP的患病风险。
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高玉婕
陈晓云
沙艳梅
王晓芬
韩光翡
黎伟娟
杨蕾
闻海梅
胡学琴
关键词 绝经后骨质疏松白族女性    
AbstractObjective To investigate the prevalence of postmenopausal osteoporosis (PMOP) and analyze its influencing factors among women at ages of 50 to 59 years in Dali Bai Autonomous Prefecture, Yunnan Province, so as to provide insights into the prevention of PMOP among menopausal women. Methods Bai Ethnic menopausal women at ages of 50 to 59 years who received healthy examination at the Center of Healthy Examination, Dali Prefecture People's Hospital from June 2017 to May 2021 were selected as the study subjects, and subjects' demographic characteristics, living habits, history of diseases, family history of osteoporosis and history of parturition were collected using self-designed questionnaires. The height, body weight and bone density were measured, and fasting blood glucose, vitamin D3, blood lipids and liver functions were detected. The factors affecting the development of PMOP were identified using a multivariable logistic regression model. Results Totally 2 000 questionnaires were allocated, and 1 584 valid questionnaires were recovered, with an effective recovery rate of 79.20%. The respondents had a mean age of ( 56.22±2.61 ) years, and mean body mass index ( BMI ) of ( 24.62±2.35 ) kg/m2. There were 497 respondents ( 31.38% ) with a family history of osteoporosis, and the prevalence of PMOP was 20.64%. Multivariable logistic regression analysis identified age ( OR=1.135, 95%CI: 1.074-1.196 ), age of menarche ( OR=1.138, 95%CI: 1.059-1.217 ), duration of menopause (OR=1.425, 95%CI: 1.228-1.622), number of parturition ( >2, OR=5.036, 95%CI: 2.972-7.101 ), smoking ( OR=2.594, 95%CI: 1.767- 3.421 ), alcohol consumption ( OR=2.051, 95%CI: 1.503-2.598 ), family history of osteoporosis ( OR=2.540, 95%CI: 1.769-3.311 ), hypertension ( OR=1.492, 95%CI: 1.406-1.578 ), diabetes ( OR=1.774, 95%CI: 1.581-1.967 ), total cholesterol ( OR=1.483, 95%CI: 1.251-1.716 ), triacylglycerol ( OR=1.801, 95%CI: 1.576-2.026 ), low-density lipoprotein cholesterol ( OR=1.614, 95%CI: 1.498-1.731 ), fasting blood glucose ( OR=1.192, 95%CI: 1.077-1.307 ), BMI ( OR=0.934, 95%CI: 0.862-0.993 ), outdoor activity ( ≥1 time/week, OR: 0.413-0.549, 95%CI: 0.329-0.637 ), age of menopause ( OR=0.909, 95%CI: 0.841-0.977 ), daily intake of calcium ( ≥600 mg, OR: 0.493-0.644, 95%CI: 0.389-0.786 ), vitamin D3 level ( ≥20 ng/mL, OR: 0.604-0.719, 95%CI: 0.523-0.853 ) and high-density lipoprotein cholesterol ( OR=0.658, 95%CI: 0.550-0.767 ) as factors affecting the development of PMOP. Conclusions The prevalence of PMOP in Dali Bai Autonomous Prefecture is similar to the nationwide level in China, and old age, smoking, alcohol consumption, a family history of osteoporosis and high blood lipid levels may increase the risk of PMOP.
Key wordspostmenopausal osteoporosis    Bai Ethnicity    women
收稿日期: 2021-06-18      出版日期: 2022-04-13
中图分类号:  R195.4  
基金资助:云南省教育厅科学研究基金项目(2020J0605)
通信作者: 陈晓云,E-mail:13887253522@163.com   
作者简介: 高玉婕,硕士,主治医师,主要从事临床医学工作
引用本文:   
高玉婕, 陈晓云, 沙艳梅, 王晓芬, 韩光翡, 黎伟娟, 杨蕾, 闻海梅, 胡学琴. 大理白族自治州女性绝经后骨质疏松的影响因素分析[J]. 预防医学, 2022, 34(4): 419-423,428.
GAO Yujie, CHEN Xiaoyun, SHA Yanmei, WANG Xiaofen, HAN Guangfei, LI Weijuan, YANG Lei, WEN Haimei, HU Xueqin. Factors affecting postmenopausal osteoporosis in Dali Bai Autonomous Prefecture. Preventive Medicine, 2022, 34(4): 419-423,428.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2022.04.020      或      http://www.zjyfyxzz.com/CN/Y2022/V34/I4/419
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