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预防医学  2023, Vol. 35 Issue (2): 158-161    DOI: 10.19485/j.cnki.issn2096-5087.2023.02.017
  妇幼保健 本期目录 | 过刊浏览 | 高级检索 |
育龄期女性卵巢储备功能下降的影响因素分析
王婷婷, 李馨
宁波市妇女儿童医院妇科,浙江 宁波 315000
Factors affecting decreased ovarian reserve among women of childbearing age
WANG Tingting, LI Xin
Department of Gynecology, Ningbo Women and Children's Hospital, Ningbo, Zhejiang 315000, China
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摘要 目的 分析育龄期女性卵巢储备功能下降(DOR)的影响因素,为预防DOR提供参考。方法 选择2021年1月—2022年6月宁波市妇女儿童医院妇科门诊就诊的患有DOR的18~40岁女性纳入DOR组,同期体检正常的18~40岁女性纳入正常组。通过问卷调查收集2组对象基本信息、运动、饮食、既往病史、生育情况和月经状况等;实验室检测卵泡刺激素(FSH)、黄体生成素(LH)、抗米勒管激素(AMH)和雌二醇(E2)水平。采用多因素logistic回归模型分析育龄期女性DOR的影响因素。结果 DOR组200例,年龄MQR)为32(9)岁;正常组200人,年龄MQR)为29(12)岁。多因素logistic回归分析结果显示,体重过低(OR=2.935,95%CI:1.374~6.269)、超重肥胖(OR=2.612,95%CI:1.335~5.065)、高油高糖高盐饮食(OR=2.653,95%CI:1.616~4.357)、月经失调(OR=1.977,95%CI:1.284~3.041)、缺乏运动(OR=3.392,95%CI:2.052~5.606)与DOR存在统计学关联。结论 体重过低、超重肥胖、高油高糖高盐饮食、月经失调和缺乏运动是育龄期女性发生DOR的影响因素。
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王婷婷
李馨
关键词 卵巢储备功能下降育龄期女性影响因素    
AbstractObjective To investigate the factors affecting decreased ovarian reserve (DOR) among women of childbearing age, so as to provide insights into prevention of DOR. Methods Women with DOR at ages of 18 to 40 years that were admitted to Department of Gynecology, Ningbo Women and Children's Hospital during the period from January 2021 to June 2022 were recruited (DOR group), while healthy women at ages of 18 to 40 years during the same period served as normal controls. Participants' demographics, exercise, diet, previous medical history, childbearing history and menstruation were collected using questionnaire surveys. The follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH) and estradiol (E2) levels were tested. Factors affecting DOR were identified among women of childbearing age using a multivariable logistic regression model. Results There were 200 participants in the DOR group, with a median (interquartile range) age of 32 (9) years, and 200 participants in the normal group, with a median (interquartile range) age of 29 (12) years. Multivariable logistic regression analysis showed that underweight (OR=2.935, 95%CI: 1.374-6.269), overweight/obesity (OR=2.612, 95%CI: 1.335-5.065), high-oil-high-glucose-high-salt diet (OR=2.653, 95%CI: 1.616-4.357), menstrual disorder (OR=1.977, 95%CI: 1.284-3.041) and lack of exercise (OR=3.392, 95%CI: 2.052-5.606) were statistically correlated with the development of DOR among women of childbearing age. Conclusions Underweight, overweight/obesity, high-oil-high-glucose-high-salt diet, menstrual disorder and lack of exercise are factors affecting the development of DOR among women of childbearing age.
Key wordsdecreased ovarian reserve    women of childbearing age    influencing factor
收稿日期: 2022-09-26      修回日期: 2022-12-09      出版日期: 2023-02-10
中图分类号:  R711  
基金资助:浙江省医药卫生科技计划项目(2022KY1160)
通信作者: 李馨,E-mail:lizixin312@163.com   
作者简介: 王婷婷,硕士,住院医师,主要从事妇产科临床工作
引用本文:   
王婷婷, 李馨. 育龄期女性卵巢储备功能下降的影响因素分析[J]. 预防医学, 2023, 35(2): 158-161.
WANG Tingting, LI Xin. Factors affecting decreased ovarian reserve among women of childbearing age. Preventive Medicine, 2023, 35(2): 158-161.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2023.02.017      或      http://www.zjyfyxzz.com/CN/Y2023/V35/I2/158
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