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预防医学  2016, Vol. 28 Issue (7): 690-694    
  综述 本期目录 | 过刊浏览 | 高级检索 |
钛及其化合物粉尘职业暴露及肺部健康效应研究进展
周莉芳1综述;张美辨1,张敏2审校
1.浙江省疾病预防控制中心,浙江杭州 310051;
2.中国疾病预防控制中心职业卫生与中毒控制所
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摘要 钛及其化合物粉尘职业暴露可引起硬金属肺病,目前关于钛及其化合物的研究以二氧化钛(TiO2)为主。一些国外机构制定或推荐了TiO2细颗粒或纳米颗粒的接触限值,而我国目前仅制定了微米级TiO2粉尘的职业接触限值。TiO2具有细胞毒性、遗传毒性和肺部毒性,可致实验动物呼吸系统肿瘤,且TiO2纳米颗粒的毒性和致癌性远高于细颗粒。流行病学调查结果显示,钛及其化合物粉尘最主要的健康危害为呼吸系统损害作用,但国内外研究均表明TiO2职业暴露与人群肺癌发生风险升高无关。为研究不同理化特性的钛及其化合物粉尘的职业暴露和人群健康效应,为不同粒径钛及其化合物职业接触限值的制定提供依据,本文对钛及其化合物的理化特性、暴露途径、职业接触限值、体外毒性、肺部毒性、致癌效应研究进展和流行病学调查作简单综述。
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周莉芳综述;张美辨
张敏审校
关键词 钛及其化合物二氧化钛职业暴露健康效应    
          出版日期: 2016-07-25
中图分类号:  R135.2  
基金资助:新增法定职业病防治关键技术研究(201402021)
通信作者: 张美辨,E-mail:mbzhang@cdc.zj.cn   
作者简介: 周莉芳,硕士,医师,主要从事职业卫生工作
引用本文:   
周莉芳综述;张美辨,张敏审校. 钛及其化合物粉尘职业暴露及肺部健康效应研究进展[J]. 预防医学, 2016, 28(7): 690-694.
链接本文:  
http://www.zjyfyxzz.com/CN/Y2016/V28/I7/690
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