Abstract:Objective To explore the association between estimated glomerular filtration rate (eGFR) and metabolic syndrome (MS). Method The data were from the China Health and Nutrition Survey (CHNS). The data included the physical measurement and biochemical markers of adults of CHNS in 2009. Finally,7309 individual observations were included in the analysis. Results According to the criteria of MS,2 034 patients were diagnosed as MS,and the prevalence was 27.83%. There were 1508 (74.14%) patients had moderate reduced eGFR in MS patients,and 3357 individuals (63.64%) were diagnosed as moderate reduced eGFR in non-MS patients. There was significant difference between two groups ( χ2=72.13,P<0.001). The incident of moderate reduced eGFR was positively associated with fasting plasma glucose(OR=1.22,95%CI: 1.06-1.42,P=0.005),triglyceride(OR=1.21,95%CI: 1.05-1.38,P=0.005) and negatively associated with HDL-C(OR=1.23,95%CI: 1.06-1.41,P=0.004). Conclusion The MS and its components might be the influencing factors of developing moderate reduced eGFR,and the screening should be focused on the population with MS.
周攀, 蒋丹, 郑睿智, 朱益民. 肾功能轻度下降与代谢综合征及其组分的关系[J]. 预防医学, 2017, 29(8): 786-789.
ZHOU Pan, JIANG Dan, ZHENG Rui-zhi, ZHU Yi-min. A study on the associations between reduced kidney function and metabolic syndrome and its components. Preventive Medicine, 2017, 29(8): 786-789.
[1] 康阳阳,刘章锁,刘东伟. 中国成人慢性肾脏病患病率荟萃分析[J]. 中国实用内科杂志,2016,36(9):785-789. [2] 李增芳,杨芬芳,蔡菊芳,等. 杭州市5310例健康体检人群慢性肾脏病的患病情况及危险因素分析[J]. 实用预防医学,2016,23(8):969-972. [3] 田进信,缪敏,袁静义,等. 尿酸水平与代谢综合征关系的横断面研究[J]. 浙江预防医学,2009,21(9):3-5. [4] ZHANG B,ZHAI F Y,DU S F,et al. The China Health and Nutrition Survey,1989-2011[J]. Obes Rev,2014,15(Suppl 1): 2-7. [5] LEVEY A S,ECKARDT K U,TSUKAMOTO Y,et al. Definition and classification of chronic kidney disease:a position statement from Kidney Disease Improving Global Outcomes(KDIGO)[J]. Kidney Int,2005,67(6):2089-2100. [6] 胡浙芳,丁钢强,章荣华,等. 3种代谢综合征诊断标准在杭州市城区人群中应用比较[J]. 浙江预防医学,2013,25(12):12-15. [7] 叶巧玉,项晓青,倪晓媚,等. 18岁以上人群代谢综合征流行的现状研究[J]. 浙江预防医学,2012,24(8):1-3, 12. [8] LU J,WANG L,LI M,et al. Metabolic syndrome among adults in China:The 2010 China Noncommunicable Disease Surveillance[J]. J Clin Endocrinol Metab,2017,102(2):507-515. [9] PRASAD G R. Metabolic syndrome and chronic kidney disease:Current status and future directions[J]. World Journal of Nephrology,2014,3(4):210. [10] KRINSLEY J S. Glycemic variability and mortality in critically ill patients:the impact of diabetes[J]. J Diabetes Sci Technol,2009,3(6):1292-1301. [11] HILL C J,CARDWELL C R,PATTERSON C C,et al. Chronic kidney disease and diabetes in the national health service:a cross-sectional survey of the U.K. national diabetes adult[J]. Diabet Med,2014,31(4):448-454. [12] CONSERVA F,PONTRELLI P,ACCETTURO M,et al. The pathogenesis of diabetic nephropathy:focus on microRNAs and proteomics[J]. Nephrol,2013,26(5):811-820. [13] 蒋阳,胡耀琪,唐娟. 慢性肾脏病患者的高血压患病情况调查[J]. 浙江预防医学,2015,27(7):703-705. [14] KAUKINEN A,KUUSNIEMI A M,HELIN H,et al. Changes in glomerular mesangium in kidneys with congenital nephrotic syndrome of the Finnish type [J]. Pediatr Nephrol,2010,25(5):867-875. [15] LEE H S,LEE J S,KOH H I,et al. Intra glomerular lipid deposition in routine biopsies[J]. Clin Nephrol,1991,36(2):67-75.