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预防医学  2017, Vol. 29 Issue (8): 786-789    DOI: 10.19485/j.cnki.issn1007-0931.2017.08.007
  论著 本期目录 | 过刊浏览 | 高级检索 |
肾功能轻度下降与代谢综合征及其组分的关系
周攀1, 蒋丹1, 郑睿智2, 朱益民2
1.舟山市普陀人民医院,浙江 舟山 316000;
2. 浙江大学医学院
A study on the associations between reduced kidney function and metabolic syndrome and its components
ZHOU Pan, JIANG Dan, ZHENG Rui-zhi, ZHU Yi-min
Putuo People' Hospital of Zhoushan City,Zhoushan,Zhejiang,316000,China
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摘要 目的 探讨肾功能轻度下降与代谢综合征(MS)及其组分的关联。方法 对2009年中国健康与营养调查数据库中7 309名研究对象资料进行分析,MS诊断采用中华医学会糖尿病分会制定的标准,肾脏损伤程度采用MDRD公式估算的肾小球滤过率(eGFR)作为判定指标,比较eGFR轻度下降与正常组各指标差异,分析肾功能轻度损伤与MS的关系。结果 共诊断出MS患者2 034例,患病率为27.83%。MS患者中eGFR轻度下降1 508例(74.14%),非MS患者eGFR轻度下降3 357例(63.64%),MS患者eGFR轻度下降比例高于非MS患者(P<0.05),且eGFR轻度下降比例随代谢异常组分的增加呈上升趋势(P<0.05)。Logistics回归分析结果显示,高空腹血糖(OR=1.22,95%CI: 1.06~1.42)、高三酰甘油(OR=1.21,95%CI: 1.05~1.38)和低高密度脂蛋白胆固醇(OR=1.23,95%CI: 1.06~1.41)是eGFR轻度下降的危险因素。结论 MS及其组分高空腹血糖、高三酰甘油和低高密度脂蛋白胆固醇是发生肾功能轻度下降的危险因素,应对MS人群的肾功能进行重点筛查。
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周攀
蒋丹
郑睿智
朱益民
关键词 肾小球滤过率代谢综合征三酰甘油血糖    
AbstractObjective To explore the association between estimated glomerular filtration rate (eGFR) and metabolic syndrome (MS). Method The data were from the China Health and Nutrition Survey (CHNS). The data included the physical measurement and biochemical markers of adults of CHNS in 2009. Finally,7309 individual observations were included in the analysis. Results According to the criteria of MS,2 034 patients were diagnosed as MS,and the prevalence was 27.83%. There were 1508 (74.14%) patients had moderate reduced eGFR in MS patients,and 3357 individuals (63.64%) were diagnosed as moderate reduced eGFR in non-MS patients. There was significant difference between two groups ( χ2=72.13,P<0.001). The incident of moderate reduced eGFR was positively associated with fasting plasma glucose(OR=1.22,95%CI: 1.06-1.42,P=0.005),triglyceride(OR=1.21,95%CI: 1.05-1.38,P=0.005) and negatively associated with HDL-C(OR=1.23,95%CI: 1.06-1.41,P=0.004). Conclusion The MS and its components might be the influencing factors of developing moderate reduced eGFR,and the screening should be focused on the population with MS.
Key wordsGlomerular filtration rate    Metabolic syndrome    Triglyceride    Fasting plasma glucose
收稿日期: 2017-03-06      修回日期: 2017-04-21      出版日期: 2017-08-10
中图分类号:  R589  
通信作者: 周攀,E-mail: zppzi1234@aliyun.com   
作者简介: 周攀,本科,副主任医师,主要从事肾内及风湿免疫工作
引用本文:   
周攀, 蒋丹, 郑睿智, 朱益民. 肾功能轻度下降与代谢综合征及其组分的关系[J]. 预防医学, 2017, 29(8): 786-789.
ZHOU Pan, JIANG Dan, ZHENG Rui-zhi, ZHU Yi-min. A study on the associations between reduced kidney function and metabolic syndrome and its components. Preventive Medicine, 2017, 29(8): 786-789.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn1007-0931.2017.08.007      或      http://www.zjyfyxzz.com/CN/Y2017/V29/I8/786
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