Please wait a minute...
文章检索
预防医学  2017, Vol. 29 Issue (8): 786-789    DOI: 10.19485/j.cnki.issn1007-0931.2017.08.007
  论著 本期目录 | 过刊浏览 | 高级检索 |
肾功能轻度下降与代谢综合征及其组分的关系
周攀1, 蒋丹1, 郑睿智2, 朱益民2
1.舟山市普陀人民医院,浙江 舟山 316000;
2. 浙江大学医学院
A study on the associations between reduced kidney function and metabolic syndrome and its components
ZHOU Pan, JIANG Dan, ZHENG Rui-zhi, ZHU Yi-min
Putuo People' Hospital of Zhoushan City,Zhoushan,Zhejiang,316000,China
全文: PDF(581 KB)  
输出: BibTeX | EndNote (RIS)      
摘要 目的 探讨肾功能轻度下降与代谢综合征(MS)及其组分的关联。方法 对2009年中国健康与营养调查数据库中7 309名研究对象资料进行分析,MS诊断采用中华医学会糖尿病分会制定的标准,肾脏损伤程度采用MDRD公式估算的肾小球滤过率(eGFR)作为判定指标,比较eGFR轻度下降与正常组各指标差异,分析肾功能轻度损伤与MS的关系。结果 共诊断出MS患者2 034例,患病率为27.83%。MS患者中eGFR轻度下降1 508例(74.14%),非MS患者eGFR轻度下降3 357例(63.64%),MS患者eGFR轻度下降比例高于非MS患者(P<0.05),且eGFR轻度下降比例随代谢异常组分的增加呈上升趋势(P<0.05)。Logistics回归分析结果显示,高空腹血糖(OR=1.22,95%CI: 1.06~1.42)、高三酰甘油(OR=1.21,95%CI: 1.05~1.38)和低高密度脂蛋白胆固醇(OR=1.23,95%CI: 1.06~1.41)是eGFR轻度下降的危险因素。结论 MS及其组分高空腹血糖、高三酰甘油和低高密度脂蛋白胆固醇是发生肾功能轻度下降的危险因素,应对MS人群的肾功能进行重点筛查。
服务
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章
周攀
蒋丹
郑睿智
朱益民
关键词 肾小球滤过率代谢综合征三酰甘油血糖    
AbstractObjective To explore the association between estimated glomerular filtration rate (eGFR) and metabolic syndrome (MS). Method The data were from the China Health and Nutrition Survey (CHNS). The data included the physical measurement and biochemical markers of adults of CHNS in 2009. Finally,7309 individual observations were included in the analysis. Results According to the criteria of MS,2 034 patients were diagnosed as MS,and the prevalence was 27.83%. There were 1508 (74.14%) patients had moderate reduced eGFR in MS patients,and 3357 individuals (63.64%) were diagnosed as moderate reduced eGFR in non-MS patients. There was significant difference between two groups ( χ2=72.13,P<0.001). The incident of moderate reduced eGFR was positively associated with fasting plasma glucose(OR=1.22,95%CI: 1.06-1.42,P=0.005),triglyceride(OR=1.21,95%CI: 1.05-1.38,P=0.005) and negatively associated with HDL-C(OR=1.23,95%CI: 1.06-1.41,P=0.004). Conclusion The MS and its components might be the influencing factors of developing moderate reduced eGFR,and the screening should be focused on the population with MS.
Key wordsGlomerular filtration rate    Metabolic syndrome    Triglyceride    Fasting plasma glucose
收稿日期: 2017-03-06      出版日期: 2017-10-17
ZTFLH:  R589  
通信作者: 周攀,E-mail: zppzi1234@aliyun.com   
作者简介: 周攀,本科,副主任医师,主要从事肾内及风湿免疫工作
引用本文:   
周攀, 蒋丹, 郑睿智, 朱益民. 肾功能轻度下降与代谢综合征及其组分的关系[J]. 预防医学, 2017, 29(8): 786-789.
ZHOU Pan, JIANG Dan, ZHENG Rui-zhi, ZHU Yi-min. A study on the associations between reduced kidney function and metabolic syndrome and its components. Preventive Medicine, 2017, 29(8): 786-789.
链接本文:  
http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn1007-0931.2017.08.007      或      http://www.zjyfyxzz.com/CN/Y2017/V29/I8/786
[1] 康阳阳,刘章锁,刘东伟. 中国成人慢性肾脏病患病率荟萃分析[J]. 中国实用内科杂志,2016,36(9):785-789.
[2] 李增芳,杨芬芳,蔡菊芳,等. 杭州市5310例健康体检人群慢性肾脏病的患病情况及危险因素分析[J]. 实用预防医学,2016,23(8):969-972.
[3] 田进信,缪敏,袁静义,等. 尿酸水平与代谢综合征关系的横断面研究[J]. 浙江预防医学,2009,21(9):3-5.
[4] ZHANG B,ZHAI F Y,DU S F,et al. The China Health and Nutrition Survey,1989-2011[J]. Obes Rev,2014,15(Suppl 1): 2-7.
[5] LEVEY A S,ECKARDT K U,TSUKAMOTO Y,et al. Definition and classification of chronic kidney disease:a position statement from Kidney Disease Improving Global Outcomes(KDIGO)[J]. Kidney Int,2005,67(6):2089-2100.
[6] 胡浙芳,丁钢强,章荣华,等. 3种代谢综合征诊断标准在杭州市城区人群中应用比较[J]. 浙江预防医学,2013,25(12):12-15.
[7] 叶巧玉,项晓青,倪晓媚,等. 18岁以上人群代谢综合征流行的现状研究[J]. 浙江预防医学,2012,24(8):1-3, 12.
[8] LU J,WANG L,LI M,et al. Metabolic syndrome among adults in China:The 2010 China Noncommunicable Disease Surveillance[J]. J Clin Endocrinol Metab,2017,102(2):507-515.
[9] PRASAD G R. Metabolic syndrome and chronic kidney disease:Current status and future directions[J]. World Journal of Nephrology,2014,3(4):210.
[10] KRINSLEY J S. Glycemic variability and mortality in critically ill patients:the impact of diabetes[J]. J Diabetes Sci Technol,2009,3(6):1292-1301.
[11] HILL C J,CARDWELL C R,PATTERSON C C,et al. Chronic kidney disease and diabetes in the national health service:a cross-sectional survey of the U.K. national diabetes adult[J]. Diabet Med,2014,31(4):448-454.
[12] CONSERVA F,PONTRELLI P,ACCETTURO M,et al. The pathogenesis of diabetic nephropathy:focus on microRNAs and proteomics[J]. Nephrol,2013,26(5):811-820.
[13] 蒋阳,胡耀琪,唐娟. 慢性肾脏病患者的高血压患病情况调查[J]. 浙江预防医学,2015,27(7):703-705.
[14] KAUKINEN A,KUUSNIEMI A M,HELIN H,et al. Changes in glomerular mesangium in kidneys with congenital nephrotic syndrome of the Finnish type [J]. Pediatr Nephrol,2010,25(5):867-875.
[15] LEE H S,LEE J S,KOH H I,et al. Intra glomerular lipid deposition in routine biopsies[J]. Clin Nephrol,1991,36(2):67-75.
[1] 马婧, 田慧艳, 韩瑞钰, 邓佩佩, 刘文娇, 王树松. 空腹血糖、胰岛素抵抗与精液质量的相关性研究[J]. 预防医学, 2019, 31(3): 274-277.
[2] 翁士仲,雷日升,林小邀,王逢慧,夏碎燕. 泰顺县40岁及以上人群血脂异常结果分析[J]. 预防医学, 2019, 31(11): 1153-1155.
[3] 胡瑜洁, 姚晓霖, 钟涛. 血糖波动对糖尿病大鼠肝脏TLR4和TNF-α表达的影响[J]. 预防医学, 2019, 31(1): 15-19.
[4] 吴霞, 陆建林, 翁根龙. 老年代谢综合征患者尿酸、B型脑钠肽和超敏C反应蛋白水平分析[J]. 预防医学, 2019, 31(1): 59-61.
[5] 谢晓,李兆强,胡杜华,谈启军. 社区糖尿病患者健康教育效果评价[J]. 预防医学, 2018, 30(9): 967-969.
[6] 李江峰,潘优津,苏小游,郑超,郑艳容,苏依所,倪秀程. 温州市成人隐匿性自身免疫糖尿病调查结果[J]. 预防医学, 2018, 30(8): 827-829.
[7] 王丽君,甘培元,何丽雅,陆怡,何文芳,徐泽汝,郭君平,华燕吟. 妊娠中期糖脂代谢水平与妊娠结局的相关性分析[J]. 预防医学, 2018, 30(8): 762-765.
[8] 章月桃,许世世,张颖. 幽门螺杆菌感染与血糖代谢异常的相关性分析[J]. 预防医学, 2018, 30(6): 633-635.
[9] 刘晓林, 黄雄昂, 林坚, 朱悦红. 糖尿病前期人群体适能干预效果评价[J]. 预防医学, 2018, 30(5): 471-475.
[10] 李少峰, 陈燕, 董陆玲, 甄刚, 李芙琴. 张家口市体检人群高尿酸血症患病现况及影响因素分析[J]. 预防医学, 2018, 30(3): 236-239.
[11] 徐佳佳, 陈文举, 周勇. 台州市健康体检人群血糖和血脂水平分析[J]. 预防医学, 2018, 30(3): 291-293.
[12] 钟皓成, 陈静, 周银姬, 诸贤含, 余美娟, 邵玉仙. 高温作业工人颈动脉粥样硬化病变调查[J]. 预防医学, 2018, 30(2): 184-185.
[13] 周宗爱, 汤智越, 陈年由, 王新红, 方卫, 许振超, 章小红, 温苏景, 尹进波. 糖尿病信息化分阶段管理效果评价[J]. 预防医学, 2018, 30(12): 1294-1296.
[14] 蒋剑波, 林玲萍, 杜丽云, 郑培奋. 杭州市中年人群三种膳食模式与代谢综合征的关系研究[J]. 预防医学, 2018, 30(12): 1222-1226.
[15] 徐妍, 刘维波, 陈赛君, 夏鸿剑, 蔡雅卫. 老年2型糖尿病患者动脉硬化与靶器官损害研究[J]. 预防医学, 2018, 30(1): 46-50.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed