Abstract:Objective To evaluate risk and the direct economic burden of malignant tumor due to type 2 diabetes mellitus. Methods Combing the data of chronic disease surveillance,follow-up and the fifth health service investigation,we calculated the population attributable risk and the direct economic burden for malignant tumor due to type 2 diabetes mellitus in order to estimate the direct economic burden for tumor caused by type 2 diabetes mellitus. Results The relative risk was 1.68 (95%CI: 1.68-1.70) for people with type 2 diabetes mellitus to develop the malignant tumor than the people without type 2 diabetes mellitus. The proportions of attributable risk (AR%) and population attributable risk (PAR%)were 40.57% and 2.05%,respectively. Moreover,the annual average hospitalization costs for malignant tumor reached 11 billion CNY,which took part 6.48% of total health service costs. And the direct economic burden for malignant tumor due to type 2 diabetes mellitus was 0.228 billion CNY. In addition,the top two highest population attributable risks were colorectal cancer and liver cancer,while the top three greatest direct economic burdens for malignant tumor or malignant tumor due to type 2 diabetes mellitus were lung cancer,colorectal cancer and stomach cancer. Conclusion From this study,we found that type 2 diabetes mellitus increased the risks of tumor and therefore lead to sharply increasing in medical costs of malignant tumor. In order to decrease the risk of malignant tumor and medical costs,we should pay more attention to the prevention of type 2 diabetes mellitus and the screening of malignant tumor due to type 2 diabetes mellitus.
胡如英, 潘劲, 武海滨, 龚巍巍, 王蒙. 常见恶性肿瘤归因2型糖尿病风险及医疗经济负担研究[J]. 预防医学, 2017, 29(8): 762-765.
HU Ru-ying, PAN Jin, WU Hai-bin, GONG Wei-wei, WANG Meng. A study on the risk and economic burden of common malignant tumor due to type 2 diabetes mellitus. Preventive Medicine, 2017, 29(8): 762-765.
[1] YANG W Y,LU J M,WENG J P,et al. Prevalence of Diabetes among Men and Women in China[J]. New England Journal of Medicine,2010,362(25):1090-1101. [2] BUTLE L M,WANG R,KOH W P,et al. Marine n-3 and saturated fatty acids in relation to risk of Colorectal cancer in Singapore Chinese:a prospective study[J]. Int J Cancer,2009,124(3):678-686. [3] FRIBERG E,ORSINI N,MANTZOROS C S,et al. Diabetes mellitus and risk of endometnial cancer:a meta-analysis[J]. Diabetologia,2007,50(7):1365-1374 [4] NOVOSYADIYY R,LEROITH D. Hyperinsulinemia and type 2 diabetes[J]. Cellcycle,2010,9 (8):1449-50 [5] GIOVANNUCCI E,HARLAN D M,ARCHER M C,et al. Diabetes and cancer: a consensus report [J]. CA Cancer J Clin,2010,33(7)1674-1678. [6] WANG C,WANG X,GONG G,et al. Increased risk of hepatocellular carcinoma in patients with diabetes mellitus:A systematic review and meta-analysis of cohort studies[J]. Int J Cancer,2011,130(7):1639-1648. [7] BI Y,LU J,WANG W,et al. Cohort Profile:Risk evaluation of cancers in Chinese diabetic Individuals: a longitudinal (REACTION)study[J]. J Diabetes,2014,6(2):147-157. [8] 胡如英,龚巍巍,王蒙,等. 2型糖尿病与恶性肿瘤发病风险关系的队列研究,中华流行病学杂志,2015,36(12):1384-13866 [9] 陈万青,郑荣寿,曾红梅,等. 1989-2008 年中国恶性肿瘤发病趋势分析[J]. 中华肿瘤杂志,2012,34 (7): 517-524. [10] 费方荣,胡如英,钟节鸣,等. 浙江省20 1 4年恶性肿瘤发病死亡分析[J]. 中华流行病学杂志. 2016,37(5):694-698 [11] 中国疾病预防控制中心,中国疾病预防控制中心慢性非传染性疾病预防控制中心. 中国慢性病及其危险因素监测报告2013[M]. 北京:军事医学出版社,2016. [12] 潘劲,胡如英,龚巍巍,等. 浙江省2007至2012年糖尿病流行特征的描述性分析析[J]. 中华内分泌杂志,2015,31(10):846-850 [13] 胡如英,俞敏,沈玉华,等. 中老年农村居民糖尿病现况调查[J]. 浙江预防医学,2014,26(10):973-766,985. [14] KO C,CHAUDHRY S. The need for a multidisciplinary approach to cancer care[J]. J Surg Res,2002,105(1):53-57. [15] 姜虹,王尚农. 2型糖尿病血糖及血脂变化情况对甲状腺癌发生的影响研究[J]. 中国实验诊断学,2014,18(11):1826-1828 [16] LO S F,CHANG S N,Muo C H,et al. Modest increase in risk of specific types of cancer types in type 2 diabetes mellitus patients[J]. Int J Cancer,2013,132(1):182-188 [17] 浙江省统计局,国家统计局浙江调查总队. 2013年浙江省国民经济和社会发展统计公报[J]. 统计科学与实践,2014,(3):4-10 [18] 浙江省卫生信息中心. 二○一四年浙江省卫生统计资料汇编[M]. 浙江省卫生和计划生育委员会,2014. [19] 郑亚明,纪立农,吴晶. 中国糖尿病经济负担研究系统综述[J]. 中华内分泌代谢杂志,2012,28 (10):821-825. [20] BEN Q,XU M,NING X,et al. Diabetes mellitus and risk of pancreatic cancer: a meta. analysis of cohort studies[J]. Eur J Cancer,2011,47(13):1928-1937. [21] HERRY S A,PRIZMENT A E,ANDERSON K E. Duration of diabetes and pancreatic cancer in a case-control study in the midwest and the iowa women′s Health study (IWHS)cohort[J]. JOP,2013,14 (3):243-249.