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预防医学  2022, Vol. 34 Issue (4): 380-384,388    DOI: 10.19485/j.cnki.issn2096-5087.2022.04.012
  疾病控制 本期目录 | 过刊浏览 | 高级检索 |
一例海港口岸境外关联新型冠状病毒感染的流行病学调查
张栋梁1, 易波2, 陈奕1, 胡群雄3, 凌锋4, 马晓2, 雷松1, 董红军2, 倪红霞2, 毛洋2, 李巧方3, 陈耀荣3, 陆烨4, 龚震宇4, 蔡剑4, 陈直平4, 吕筠5, 许国章2
1.宁波市疾病预防控制中心传染病防制所,浙江 宁波 315010;
2.宁波市疾病预防控制中心,浙江 宁波 315010;
3.宁波市北仑区疾病预防控制中心,浙江 宁波 315800;
4.浙江省疾病预防控制中心,浙江 杭州 310051;
5.北京大学,北京 100191
Epidemiological investigation of a case with SARS-CoV-2 infection associated with overseas countries at an international harbor
ZHANG Dongliang1, YI Bo2, CHEN Yi1, HU Qunxiong3, LING Feng4, MA Xiao2, LEI Song1, DONG Hongjun2, NI Hongxia2, MAO Yang2, LI Qiaofang3, CHEN Yaorong3, LU Ye4, GONG Zhenyu4, CAI Jian4, CHEN Zhiping4, LÜ Jun5, XU Guozhang2
1. Department of Communicable Disease Control and Prevention, Ningbo Center for Disease Control and Prevention, Ningbo, Zhejiang 315010, China;
2. Ningbo Center for Disease Control and Prevention, Ningbo, Zhejiang 315010, China;
3. Beilun Center for Disease Control and Prevention, Ningbo, Zhejiang 315800, China;
4. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China;
5. Peking University, Beijing 100191, China
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摘要 目的 调查浙江省宁波舟山港一例境外关联新型冠状病毒(新冠病毒)感染的感染来源和危险因素,为完善海港口岸新型冠状病毒肺炎(新冠肺炎)疫情防控措施提供依据。方法 宁波市和北仑区疾病预防控制中心组织开展病例搜索和流行病学调查,收集感染者基本信息、免疫史和近14天暴露史等,排查密切接触者;采集感染者标本检测新冠病毒核酸和全基因组序列,并与全球新冠病毒全基因组共享数据库GISAID比对;对感染来源和传播途径开展溯源调查和评估。结果 2021年8月10日宁波舟山港M公司在新冠病毒核酸例行筛查时检出1例阳性,8月11日经北仑区疾控中心、宁波市疾控中心确认核酸阳性。基因测序显示为德尔塔毒株(B.1.617.2进化分支),与俄罗斯2021年6月上传的病毒(Russia/MOW-RII-MH27356S/2021)序列同源性最高。流行病学调查结果显示,该病例为宁波舟山港从事外籍集装箱货轮捆扎作业工,8月4—5日在“长锦秋田”号货轮作业过程中,无防护情况下曾与外籍船员交流、接触物品。该货轮曾于7月27—29日停靠俄罗斯符拉迪沃斯托克,8月4日停靠M公司码头,8月5日驶离,8月8日该货轮11名船员检出新冠病毒核酸阳性。本次疫情共报告1例新冠肺炎无症状感染者;判定254名密切接触者和617名次密切接触者,新冠病毒核酸均为阴性。截至8月25日,无新增感染者报告,结束应急响应。结论 本次疫情为一起境外关联散发疫情,宁波舟山港登轮作业人员通过接触境外船员或物品感染德尔塔毒株,未引起疫情扩散传播。口岸疫情防控需加强高风险岗位重点人群闭环管理,提高核酸检测频次,提升口岸所在地区精准、快速处置疫情能力。
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关键词 新型冠状病毒肺炎新型冠状病毒德尔塔毒株流行病学口岸    
AbstractObjective To investigate the origin of infection and risk factors of a case with SARS-CoV-2 infection associated with overseas countries in the Ningbo-Zhoushan Port, Zhejiang Province, so as to provide the evidence for improving the COVID-19 control measures at ports. Methods Ningbo Center for Disease Control and Prevention ( CDC ) and Beilun CDC conducted case finding and epidemiological surveys immediately after being informed. The general information, history of vaccination and the travel during the latest 14 days were collected from the positive case, and all close contacts were tracked. Saliva samples were collected for SARS-CoV-2 nucleic acid testing and whole-genome sequencing, and the sequencing results were aligned with the GISAID's EpiCoV database. The origin of infection and transmission route of the positive case was investigated. Results A case was identified positive for SARS-CoV-2 nucleic acid during company M's routine screening in the Ningbo-Zhoushan Port on August 10, 2021, and was confirmed positive for SARS-CoV-2 nucleic acid by Beilun CDC and Ningbo CDC on August 11. Whole-genome sequencing showed SARS-CoV-2 B.1.617.2 ( Delta ) variant, which shared the highest homology with the virus sequence uploaded by Russia on June, 2021 ( Russia/MOW-RII-MH27356S/2021 ). The case was a bundling worker for overseas container ships, and reported communicated with foreign boatmen and contacted materials without protected interventions on the SINOKOR AKITA Container Ship between August 4 and 5, 2021. This ship anchored at Vladivostok, Russia from July 27 to 29, anchored at Ningbo Harbor on August 4, and departed on August 5. Then, 11 boatmen from this ship were tested positive for SARS-CoV-2 nucleic acid on August 8. One asymptomatic case was reported in this epidemic; 254 close contacts and 617 secondary close contacts were identified, and all were tested negative for SARS-CoV-2 nucleic acid. No new cases with SARS-CoV-2 infections were detected until August 25, 2021, and the emergency response was therefore terminated. Conclusions The infection was a sporadic COVID-19 epidemic associated with overseas countries, which was caused by Delta variant infection through contacts with foreign boatmen or materials by a bundling worker in Ningbo-Zhoushan Port; fortunately, no epidemic spread occurred. Intensified closed-loop management and increased frequency of SARS-CoV-2 nucleic acid test among high-risk populations, and improving the precision and rapid emergency treatment of COVID-19 epidemics are required for the containment of COVID-19 at ports.
Key wordsCOVID-19    SARS-CoV-2    Delta variant    epidemiology    port
收稿日期: 2022-02-08      修回日期: 2022-03-02      出版日期: 2022-04-10
中图分类号:  R563.14  
基金资助:国家自然科学基金(82073514,91846303); 宁波市科技重大专项——新型冠状病毒肺炎疫情防控应急科技攻关项目(2020C5001); 宁波市医疗卫生品牌学科(PPXK2018-10); 宁波市自然科学基金(2018A610239)
通信作者: 许国章,E-mail:xugz@nbcdc.org.cn   
作者简介: 张栋梁,硕士,副主任医师,主要从事急性传染病防制工作
引用本文:   
张栋梁, 易波, 陈奕, 胡群雄, 凌锋, 马晓, 雷松, 董红军, 倪红霞, 毛洋, 李巧方, 陈耀荣, 陆烨, 龚震宇, 蔡剑, 陈直平, 吕筠, 许国章. 一例海港口岸境外关联新型冠状病毒感染的流行病学调查[J]. 预防医学, 2022, 34(4): 380-384,388.
ZHANG Dongliang, YI Bo, CHEN Yi, HU Qunxiong, LING Feng, MA Xiao, LEI Song, DONG Hongjun, NI Hongxia, MAO Yang, LI Qiaofang, CHEN Yaorong, LU Ye, GONG Zhenyu, CAI Jian, CHEN Zhiping, LÜ Jun, XU Guozhang. Epidemiological investigation of a case with SARS-CoV-2 infection associated with overseas countries at an international harbor. Preventive Medicine, 2022, 34(4): 380-384,388.
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