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预防医学  2021, Vol. 33 Issue (12): 1276-1281    DOI: 10.19485/j.cnki.issn2096-5087.2021.12.022
  妇幼保健 本期目录 | 过刊浏览 | 高级检索 |
维生素D水平与孕产妇抑郁关联性的Meta分析
陈轶铭, 全宁斌, 吴茵茵
杭州师范大学公共卫生学院流行病与卫生统计学系,浙江 杭州 311121
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摘要 目的 分析维生素D水平与孕产妇抑郁的关联,为防治孕产妇抑郁提供依据。方法 系统检索中国知网、万方中国学术期刊数据库、维普中文科技期刊数据库、PubMed和Embase等中英文数据库,收集建库至2021年4月15日有关维生素D水平与孕产妇抑郁关联的文献,采用加权均数差(WMD)和OR值为效应指标,采用亚组分析探讨异质性来源,采用敏感性分析结局指标的稳定性,采用Begg's检验和Egger's检验评估发表偏倚。结果 初期共检索文献917篇,最终纳入16篇,其中队列研究8篇,病例对照研究8篇,均为高质量研究。Meta分析结果显示:产前抑郁组维生素D水平低于对照组(WMD=-6.45,95%CI:-11.01~-1.89,P=0.006);产后抑郁组维生素D水平低于对照组(WMD=-8.56,95%CI:-10.50~-6.63,P<0.001);产后抑郁组维生素D缺乏风险高于对照组(OR=1.50,95%CI:1.16~1.94,P=0.002);维生素D水平较低组与较高组抑郁评分差异无统计学意义(WMD=0.20,95%CI:-1.07~1.48,P=0.755)。根据维生素D缺乏截断值的不同进行亚组分析,以50 nmol/L为维生素D缺乏截断值的研究显示,产后抑郁组比对照组更容易发生维生素D缺乏(OR=1.37,95%CI:1.07~1.76,P=0.012)。敏感性分析显示研究结果较稳定。Begg's检验与Egger's检验均显示无明显发表偏倚。结论 维生素D水平与孕产妇抑郁具有统计学联系,维生素D水平较低容易增加产前和产后抑郁的发病风险。
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陈轶铭
全宁斌
吴茵茵
关键词 维生素D产前抑郁产后抑郁Meta分析    
收稿日期: 2021-05-26      出版日期: 2021-12-03
ZTFLH:  R173  
通信作者: 吴茵茵,E-mail:20110106@hznu.edu.cn   
作者简介: 陈轶铭,硕士在读
引用本文:   
陈轶铭, 全宁斌, 吴茵茵. 维生素D水平与孕产妇抑郁关联性的Meta分析[J]. 预防医学, 2021, 33(12): 1276-1281.
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http://www.zjyfyxzz.com/CN/Y2021/V33/I12/1276
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