Abstract：Objective To analyze the present post setting situation of CDCs in Zhejiang Province,and to provide evidence for further improvement and standardization of post setting. Methods The data of post setting were collected by questionnaires from all levels of CDCs in Zhejiang Province. The compliance and rationality of post setting structure were evaluated by national and provincial normative policy documents. Results Ninety seven CDCs had implemented the post setting. Professional technical posts had the highest proportion （above 80%）among three kinds of posts. As the approved proportions of posts classification and professional titles were approved by the local government,there were differences between different levels of CDCs. The approved proportion of ground skilled posts and management posts between municipal and county CDCs had a relatively higher degree of dispersion,and the CVs of ground skilled posts and management posts of municipal CDCs were 72.3% and 65.6%,and the CVs of county CDCs were 101.6% and 82.1%. In terms of the approved professional titles structural proportion,the degree of dispersion appeared to be higher in senior titles and primary titles approved proportion of municipal CDCs（CV=29.1%,28.5%）,while the degree of dispersion was higher in senior titles and vice-senior titles of county CDCs（CV=58.9%,21.8%）. Meanwhile,the approved proportions of senior titles in municipal and county CDCs were lower with the averages of 32.2% and 17.0%. The posts of infectious disease prevention and control and laboratory detection were accounting for the majority posts in municipal and county CDCs with average percentages of 47.8% and 45.1%. Conclusion The present situation of post structural proportion meets the relevant requirements generally. However,there are some phenomena of non-standard approved proportion of ground skilled posts and management posts and low senior titles approved proportion. Meanwhile,the percentage of infectious disease prevention and control and laboratory detection posts appears to be lower in county CDCs.