Abstract：Objective To analyze the prevalence of latent infection of pathogens of hand,foot and mouth disease (HFMD) in Chinese healthy population and its influencing factors,so as to provide reference for the prevention and control of HFMD. Methods Literature on the latent infection of HFMD was searched in Chinese and English databases,such as CNKI,Wanfang,CBMd,PubMed,Web of Science and ScienceDirect,from January 1,2000 to December 31,2019. The pooled rate and its 95% confidence interval(95%CI)were used to assess the latent infection rate of HFMD pathogens in healthy Chinese population. Results A total of 442 articles were retrieved,and 31 articles were finally included in the quantitative meta-analysis. The results showed that the latent infection rate of human enteroviruses in healthy Chinese population was 18.8%(95%CI:16.1%-21.6%),and the latent infection rates of EV71,CV-A16 and other HEVs were 3.7%(95%CI:2.5%-4.9%),1.9%(95%CI:1.0%-2.9%) and 15.1%(95%CI:11.9%-18.3%),respectively. The latent infection rates of HEVs in healthy men and women in China were 16.7%(95%CI:12.9%-20.4%) and 14.4%(95%CI:10.8%-18.0%),respectively. The latent infection rates of human enterovirues HEVs in the healthy population aged 0-5 years and over 5 years were 24.4%(95%CI:20.4%-28.5%) and 9.4%(95%CI:6.5%-12.2%),respectively. Meta regression analysis showed that the associated factors for the latent infection rate of HEVs in Chinese healthy population included sampling period,sampling area and study population.Sensitivity analysis showed that there was no significant change on meta results after the exclusion of individual studies one by one(p>0.05). Begg's tests,Egger's tests and funnel plots all indicated the existence of publication bias. Trim and fill method showed that the recessive infection rate was reduced after adjustment(p<0.05). Conclusions The latent infection rate of HFMD pathogens is high in healthy people in China,and it is mainly caused by other HEVs. Males and children aged under 5 years are at high risk of latent infection of HEVs.
李鹏, 唐安, 李科峰, 吴昺, 严剑波. 中国健康人群手足口病病原体隐性感染率的Meta分析[J]. 预防医学, 2020, 32(7): 659-665.
LI Peng, TANG An, LI Kefeng, WU Bing, YAN Jianbo. Prevalence of latent infection of pathogens of hand, foot and mouth disease in healthy people in China: A meta-analysis. Preventive Medicine, 2020, 32(7): 659-665.
[1] 赵奇,朱俊萍.中国手足口病的流行状况及病原谱变化分析[J].病毒学报,2015,31(5):554-559. [2] SOLOMON T,LEWTHWAITE P,PERERA D,et al.Virology,epid-emiology,pathogenesis,and control of enterovirus 71[J].Lancet Infect Dis,2010,10(11):778-790. [3] 阴珊珊,孟祥鹏.手足口病流行病学及病原学研究进展[J].泰山医学院学报,2014,35(5):458-460. [4] MENG J,GAO C,TANG C,et al.Prevalence of hypochondriac symptoms among health science students in China:a systematic review and meta-analysis[J].PLoS One,2019,14(9):e0222663. [5] LI P,TONG Z D,LI K F,et al.Seroprevalence of severe fever with thrombocytopenia syndrome virus in China:a systematic review and meta-analysis[J].PLoS One,2017,12(4):e0175592. [6] 李洋,张相萍,包小兵.2010年—2011年河南省安阳市健康人群手足口病原体隐性感染调查及分析[J].中国卫生检验杂志,2013,23(9):2173-2175,2179. [7] 蔡妙森,任燕.2012年深圳市某社区健康人群手足口病隐性感染调查研究[J].中国卫生检验杂志,2013,23(10):2355-2357. [8] 杨华可,袁达康,黄勇,等.东莞市2009年正常人群手足口病隐性感染调查[J].中国卫生检验杂志,2010,20(6):1519-1520. [9] 康宁,谭毅,闭福银,等.广西壮族自治区南宁市50例非手足口病幼儿肠道病毒感染状况分析[J].疾病监测,2010,25(9):682-683,690. [10] 高雯,杨梅,项东,等.健康儿童手足口病病毒隐性感染状况及亲子家庭聚集性研究[J].医学动物防制,2016,32(7):754-756. [11] 侯占英,牛学义.健康学龄前儿童手足口病病原隐性感染情况调查及危险因素分析[J].中国处方药,2015,14(1):117-118. [12] 刘凤仁,刘渠,王荀,等.健康幼托儿童手足口病隐性感染状况调查及其危险因素分析[J].热带医学杂志,2014,14(2):246-250. [13] 冯秀,游胜,邱秋,等.萍乡市健康人群手足口病肠道病毒隐性感染状况分析[J].现代预防医学,2015,42(22):4178-4180. [14] 莫礼峰,王兰,任燕,等.深圳市春秋两季健康人群手足口病病原隐性感染调查[J].现代医药卫生,2012,28(12):1916-1917. [15] 任燕,汪东篱,曾雁玲,等.深圳市某地2011年正常人群手足口病隐性感染调查研究[J].热带医学杂志,2012,12(8):1025-1027. [16] 张莉. 临沂市手足口病检测结果分析与防控对策研究[D].济南:山东大学,2015. [17] 殷方青,石增宝.兰山区健康人群及手足口病例密接人群肠道病毒带毒率调查[J].山东医学高等专科学校学报,2011,33(6):430-432. [18] 曾汉日,张永慧,孙立梅,等.手足口病病例密切接触者和健康人群肠道病毒带毒率调查[J].中国卫生检验杂志,2012,22(5):1158-1159,1162. [19] 谢蕾,王锦,张姝,等.宁波地区手足口病人密切接触人群肠道病毒带毒率调查[J].中国卫生检验杂志,2013,23(5):1145-1147. [20] 刘立,陆辉,田会芳,等.石家庄市赞皇县健康儿童肠道病毒携带情况分析[J].中国妇幼保健,2012,27(11):1661-1663. [21] 刘翠华. 济宁市健康人群及手足口病密切接触人群带毒率调查分析[J].中国社区师(医学专业),2011,13(10):377-378. [22] 孙宝昌,高娟,陈栋,等.儿童手足口病病毒隐性感染情况研究[J].实用预防医学,2014,21(8):914-916. [23] 汪东篱,姚炜,冯滨,等.2010年深圳市某区幼儿园手足口病隐性感染调查[J].中国卫生检验杂志,2012,22(4):885-887. [24] 何玥,曾斤日,魏煌忠,等.在园儿童携带EV71和CoxA16的调查研究[J].中外医疗,2012,31(17):1-2. [25] 牛卫东,戴蕾,史军.郑州市健康人群手足口病隐性感染调查[J].中国卫生检验杂志,2012,22(9):2209-2210,2213. [26] 张相萍,李洋.2010年安阳市正常人群手足口病隐性感染调查[J].河南预防医学杂志,2012,23(3):173-174. [27] 移钱华,张翔,汤奋扬,等.泰州市海陵区托幼机构儿童手足口病肠道病毒检测和发病率观察[J].预防医学情报杂志,2013,29(7):533-535. [28] 邓慧玲,王小燕,马超锋,等.手足口病1 020例及健康儿童207例病原及流行病学调查分析[J].陕西医学杂志,2011,40(9):1226-1228. [29] 姜文国,丁淑军,高中静,等.手足口病流行期健康儿童及其监护人肠道病毒带毒状况调查[J].中国病原生物学杂志,2011,6(11):857-860. [30] 张爱华,薛家芹,陈琛,等.泰安市106名手足口病密切接触者隐性感染状况调查[J].预防医学论坛,2012,18(7):541-542. [31] 陈风阳. 邢台市手足口病普通病例与健康儿童手足口病隐性感染肠道病毒类型比较分析[J].河北医药,2013,35(14):2190-2191. [32] 袁伟,程秀伟,刘雅琼,等.健康儿童手足口病隐性感染情况及影响因素分析[J].预防医学情报杂志,2018,34(8):1062-1065. [33] 谢燕,夏利,袁娟.陕西省西安地区手足口病隐性感染状况调查研究[J].实用临床医药杂志,2019,23(15):45-47,52. [34] WU Q,FU X,JIANG L,et al.Prevalence of enteroviruses in healthy populations and excretion of pathogens in patients with hand,foot,and mouth disease in a highly endemic area of southwest China[J].PLoS One,2017,12(7):e0181234. [35] ZHANG X,WANG H,DING S,et al.Prevalence of enteroviruses in children with and without hand,foot,and mouth disease in China[J].BMC Infec Dis,2013,13:606. [36] WU W,XU W B,CHEN L,et al.Molecular identification and analysis of human enter viruses isolated from healthy children in Shenzhen,China from 2010 to 2011[J].PLoS One,2013,8(6):e64889. [37] 吴晨,吴昊澄,丁哲渊,等.2008—2015年浙江省手足口病流行特征分析[J].疾病监测,2016,31(10):831-837. [38] 隋美丽,李懿,刘新奎,等.手足口病流行病学、病原学及重症化机制的研究进展[J].中国病原生物学杂志,2017,12(1):92-96. [39] 张天嵩,刘江波,钟文昭.Stata在探索异质性来源—Meta回归分析中的应用[J].循证医学,2009,9(1):48-50.
