Abstract：Patients with leprosy varies in the degree of cellular immune defect,but the mechanism remains unclear. Macrophages,a group of immunocytes with different phenotypes and functions,are important cell components in the immune response,and participate in the occurrence and development of leprosy. The polarization of macrophages phenotypes is regulated by many factors. In tuberculoid leprosy,macrophages are polarized into M1 phenotype;in lepromatous leprosy,macrophages are polarized into M2 phenotype. We reviewed the research about the effects of macrophage in the pathogenic mechanism of leprosy infection,so as to provide a theoretical basis for leprosy prevention and treatment.
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